Clone Number: JMMR-2717
Host: Mouse Clonality: Recombinant Monoclonal
Applications： WB
Reactivity: Human
Synonyms: HsHec1, NDC80, HEC, KNTC2
Shipping: Ambient temperature
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| Isotype | IgG1 |
| Conjugate | Unconjugated |
| Synonyms | HsHec1, NDC80, HEC, KNTC2 |
| UniProt ID | |
| Immunogen | |
| MW (kDa) | |
| Specificity |
| Applications | Dilution | Recommended Species |
|---|---|---|
| WB | 1:500 - 1:1000 | Human |
| Purity | Protein A purified |
| Constituents | PBS, Glycerol, BSA |
| Storage | Store at -20°C. Avoid freeze/thaw cycles. |
| Stability | Stable for 12 months from date of receipt/reconstitution. |
Background
HEC1 is one of the proteins of outer kinetochore which has microtubule-binding domains. It forms a heterotetramer with proteins NUF2, SPC25, and SPC24. HEC1 acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. It Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.
Cellular location
Nucleus, Kinetochore
| WB | |
|---|---|
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Blocking buffer: 5% NFDM/TBST |
Research Use
For research use only, not for use in diagnostic procedures.
