Clone Number: 11327
Host: Mouse Clonality: Recombinant Monoclonal
Applications： WB
Reactivity: Human, Mouse
Synonyms: MAP2K2, MEK2, MKK2, PRKMK2
Shipping: Ambient temperature
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| Isotype | IgG1 |
| Conjugate | Unconjugated |
| Synonyms | MAP2K2, MEK2, MKK2, PRKMK2 |
| UniProt ID | |
| Immunogen | |
| MW (kDa) | |
| Specificity |
| Applications | Dilution | Recommended Species |
|---|---|---|
| WB | 1:200 - 1:1000 | Human, Mouse |
| Purity | Protein G purified |
| Constituents | PBS, Glycerol, BSA |
| Storage | Store at -20°C. Avoid freeze/thaw cycles. |
| Stability | Stable for 12 months from date of receipt/reconstitution. |
Background
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.
Cellular location
Cytoplasm, Membrane
| WB | |
|---|---|
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Blocking buffer: 5% NFDM/TBST |
Research Use
For research use only, not for use in diagnostic procedures.
