Background
Axl, also known as Ufo or Ark, is a member of receptor tyrosine kinase of the TAM family. Axl is a single-pass type I membrane protein containing two fibronectin type-III domains, two Ig-like C2-type domains and one protein kinase domain. Axl mRNA is widely expressed with highest levels in the heart and skeletal muscle. Gas6 has been identified as a ligand for human Axl. Gas6/Axl signaling plays a role in cell survival, cell proliferation, migration and differentiation. This antibody detects a single band at 140 kDa, which is considered to represent the auto-phosphorylated form of endogenous Axl.Phosphorylation of Axl on Tyr702 was also reported in select carcinoma cell lines.
Cellular location
Membrane
