Background
alpha-internexin is a Class IV intermediate filament approximately 66 KDa. The protein was originally purified from rat optic nerve and spinal cord. In some mature neurons it can be the only neurofilament expressed. alpha-internexin is present in developing neuroblasts and in the Central Nervous System of adults. The protein is a major component of the intermediate filament network in small interneurons and cerebellar granule cells, where it is present in the parallel fibers. It is expressed in early development in the neuroblast along with α-internexin and peripherin. As development continues into neurons the neurofilament triplet proteins are expressed in increasing molecular mass order as α-internexin expression decreases.
Cellular location
Cytoskeleton
