Background
Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, ubiquitylation, and etc. Khib is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine 2-hydroxyisobutyrylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of Khib suggest that it is mechanistically and functionally different from histone lysine acetylation.
Cellular location
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