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Recombinant Rabbit Monoclonal
Anti-Acetyllysine Rabbit mAb
Catalog Number: PTM-105RM
$ 320

Clone Number: PA-070-53

Host: Rabbit Clonality: Recombinant Monoclonal

Applications： WB IHC-P

Reactivity: All

Synonyms: Kac

Product Size
100 μl
Quantity

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms Kac
UniProt ID

/

Immunogen Acetylated lysine peptides
MW (kDa) Multiple
Specificity Anti-Acetyllysine Rabbit mAb detects proteins with acetylated lysine residues. This pan antibody recognizes acetylated lysine independent of its surrounding sequences.
Product Usage Information
Applications Dilution Recommended Species
WB 1:1000 All
IHC-P 1:200 - 1:1000 Human, Mouse, Rat
Properties
Purity Protein A purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

The reversible lysine acetylation of histones and non-histone proteins is a crucial post-translational modification that regulates diverse cellular processes, including chromatin dynamics, gene expression, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. More than 20 acetyltransferases and 18 histone deacetylases (HDACs) have been identified, but the mechanisms governing substrate selection and site specificity of these enzymes remain unclear. Dysregulation of protein acetylation has been implicated in the development of cancers and other diseases, and HDACs have become likely targets for anti-cancer drugs.

Cellular location

/

Images
Dot Blot

Peptide amount: 4 ng, 20ng, 100 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 30 seconds
The list of peptides used in the experiment is provided below.
Lane 1: Acetyllysine peptide library. Dot 2: Crotonyllysine peptide library.
Dot 3: Butyryllsine peptide library. Dot 4: 2-Hydroxyisobutyryllysine peptide library.
Dot 5: β-Hydroxybutyryllysine peptide library. Dot 6: Unmodified peptide library.
WB

Lysate: HeLa cells
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab: Lane 1, PTM-105RM pre-adsorbed with 3 μM synthetic acetylated lysine peptides; Lane 2, PTM-105RM pre-adsorbed with 3μM unmodified peptides.
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: 1: HeLa; 2: NIH-3T3; 3: BRL; 4: Mouse liver; 5: Mouse kidney
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: (-) HeLa cells, (+) HeLa cells treated with 30 mM sodium butyrate for 4 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60+ seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: (-) HepG2 cells, (+) HepG cells treated with 5 mM sodium butyrate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60+ seconds
Predicted band size: Multiple
Observed band size: Multiple
IHC-P

Tissue: Human liver
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-105RM.

Tissue: Mouse cerebrum
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-105RM.

Tissue: Rat liver
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-105RM.

Research Use

For research use only, not for use in diagnostic procedures.

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  • Non-enzymatic acetylation of lysine residues affects the stability of Rubisco activase
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    Authors Lili Yang, et al.
    Applications Unspecified
    Reactivity
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    Year 2026
    Journal PHYTOMEDICINE
    Authors Tong Li, et al.
    Applications Unspecified
    Reactivity
  • Ginsenoside Rg5 targets the KAT8-CISD2 axis to maintain mitochondrial homeostasis and antagonize senescence
    Year 2026
    Journal PHYTOMEDICINE
    Authors Jinmeng Chu, et al.
    Applications Unspecified
    Reactivity
  • Deciphering the Atlas of Protein Acetylation, 2-Hydroxyisobutyrylation, and Malonylation in Developing Cassava Roots
    Year 2026
    Journal JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
    Authors Lili Fu, et al.
    Applications Unspecified
    Reactivity
  • Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation
    Year 2026
    Journal Journal of Integrative Medicine-JIM
    Authors Yi-fan Miao, et al.
    Applications Unspecified
    Reactivity
  • Systematic proteomics analysis of lysine acetylation reveals critical features of renal proteins in kidney calculi formation
    Year 2026
    Journal PLoS One
    Authors Shiwei Zhang, et al.
    Applications Unspecified
    Reactivity
  • Acetylation dynamics of MrATG4 governing autophagy-mediated conidiation in an entomopathogenic fungus
    Year 2026
    Journal PLoS Pathogens
    Authors Deshui Yu, et al.
    Applications Unspecified
    Reactivity
  • NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin
    Year 2025
    Journal iScience
    Authors Yumeng Wang, et al.
    Applications Unspecified
    Reactivity
  • HDAC3 activates endothelial NLRP3 inflammasome and promotes atherosclerosis via inhibiting the acetylation of specificity protein 1
    Year 2025
    Journal CELL DEATH AND DIFFERENTIATION
    Authors Chen Lifang, et al.
    Applications Unspecified
    Reactivity
  • Dcaf15-mediated EphA2 degradation triggers disruption of the blood-brain barrier during Streptococcus suis meningitis
    Year 2025
    Journal Communications Biology
    Authors Yin Hang, et al.
    Applications Unspecified
    Reactivity
  • HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma
    Year 2025
    Journal Cell Death & Disease
    Authors He Jiang, et al.
    Applications Unspecified
    Reactivity
  • Dynamic acetylation of a conserved lysine impacts glycerol kinase activity and abundance in the haloarchaeon Haloferax volcanii
    Year 2025
    Journal JOURNAL OF BIOLOGICAL CHEMISTRY
    Authors Karol M. Sanchez, et al.
    Applications Unspecified
    Reactivity
  • TLR9 decreases FOXO3 expression to prevent excessive inflammation in macrophage activation syndrome
    Year 2025
    Journal iScience
    Authors Mengyan Wang, et al.
    Applications Unspecified
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  • Insights into the lysine acetylation in growth and pathogenicity for pine wilt nematode Bursaphelenchus xylophilus
    Year 2025
    Journal PEST MANAGEMENT SCIENCE
    Authors Lichao Wang, et al.
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  • GNAT family Pat2 is required for long-term survival on glycerol and catalyzes lysine acetylation of glycerol kinase in hypersaline-adapted archaea
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    Authors Heather N. Judd, et al.
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    Authors Siyao Sun, et al.
    Applications Unspecified
    Reactivity
  • Functional studies on PdbRAV2 transcription factor mediated positive regulation of drought tolerance in Populus davidiana × P. bolleana
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    Journal Plant Stress
    Authors Xiaofu Li, et al.
    Applications Unspecified
    Reactivity
  • Sirtuin 6 is a histone delactylase
    Year 2025
    Journal JOURNAL OF BIOLOGICAL CHEMISTRY
    Authors Garrison A. Nickel, et al.
    Applications Unspecified
    Reactivity
  • Crotonate enhances intestinal regeneration after injury via HBO1-mediated H3K14 crotonylation
    Year 2025
    Journal Nature Communications
    Authors Xiao Yanhui, et al.
    Applications Unspecified
    Reactivity
  • TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation
    Year 2025
    Journal AGING CELL
    Authors Yue Wang, et al.
    Applications Unspecified
    Reactivity
  • Deacetylase SIRT1 modulates antiviral innate immunity and autoimmune diseases
    Year 2025
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    Authors Shuang-Shuang Yu, et al.
    Applications Unspecified
    Reactivity
  • Saikosaponin D Mitigates Radioresistance in Triple-Negative Breast Cancer by Inducing MRE11 De-Lactylation via HIF1α/HDAC5 Pathway
    Year 2025
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    Authors Jingyi Li, et al.
    Applications Unspecified
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  • Restoration of SIRT3 Expression in Aged Mice Alleviates UUO-Induced Renal Fibrosis by Reducing GSK-3β Hyperacetylation
    Year 2025
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    Authors Jing Wang, et al.
    Applications Unspecified
    Reactivity
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    Authors Chenyun Dai, et al.
    Applications Unspecified
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  • Histone Acetyltransferase MOF-Mediated AURKB K215 Acetylation Drives Breast Cancer Cell Proliferation via c-MYC Stabilization
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    Authors Yujuan Miao, et al.
    Applications Unspecified
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    Year 2025
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    Applications Unspecified
    Reactivity
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    Reactivity
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    Applications Unspecified
    Reactivity
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    Reactivity
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    Authors Zhu Liang, et al.
    Applications Unspecified
    Reactivity
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    Year 2025
    Journal TOXICOLOGY AND APPLIED PHARMACOLOGY
    Authors Xiaomin Xie, et al.
    Applications Unspecified
    Reactivity
  • Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression
    Year 2025
    Journal Journal of Translational Medicine
    Authors Liu Jinlin, et al.
    Applications Unspecified
    Reactivity
  • HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis
    Year 2025
    Journal EMBO REPORTS
    Authors SongTing , et al.
    Applications Unspecified
    Reactivity
  • SIRT7 Is a Lysine Deacylase with a Preference for Depropionylation and Demyristoylation
    Year 2025
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Mohammad Golam Kibria, et al.
    Applications Unspecified
    Reactivity
  • Simvastatin inhibits PD-L1 via ILF3 to induce ferroptosis in gastric cancer cells
    Year 2025
    Journal Cell Death & Disease
    Authors Sun Danping, et al.
    Applications Unspecified
    Reactivity
  • β-hydroxybutyrate facilitates mitochondrial-derived vesicle biogenesis and improves mitochondrial functions
    Year 2025
    Journal MOLECULAR CELL
    Authors Min Tang, et al.
    Applications Unspecified
    Reactivity
  • Ginsenoside Rc maintains sleep rhythm homeostasis by alleviating oxidative stress
    Year 2025
    Journal PHYTOMEDICINE
    Authors Xuenan Chen, et al.
    Applications Unspecified
    Reactivity
  • Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis
    Year 2025
    Journal Nature Communications
    Authors Wang Meng, et al.
    Applications Unspecified
    Reactivity
  • Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
    Year 2025
    Journal Bone Research
    Authors Xian Yansi, et al.
    Applications Unspecified
    Reactivity
  • SIRT5 promotes the osteo-inductive potential of BMP9 by stabilizing the HIF-1α protein in mouse embryonic fibroblasts
    Year 2025
    Journal Genes & Diseases
    Authors Lu Liu, et al.
    Applications Unspecified
    Reactivity
  • Histone acetyltransferase BmMOF inhibits the proliferation of the Bombyx mori nucleopolyhedrovirus by targeting Bmp53
    Year 2025
    Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
    Authors Meng Miao, et al.
    Applications Unspecified
    Reactivity
  • Overexpression of Acetylation-Defective Heat Shock Protein 60 Inhibits the Proliferation of Nucleopolyhedrovirus in Bombyx mori
    Year 2025
    Journal ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
    Authors Yao Li, et al.
    Applications Unspecified
    Reactivity
  • Lysine acetylation modulates drought stress responses in birch (Betula platyphylla) through metabolic and transcriptional pathway regulation
    Year 2025
    Journal PLANT JOURNAL
    Authors Shilin Sun, et al.
    Applications Unspecified
    Reactivity
  • GlSIRT1 deacetylates and activates pyruvate kinase to improve pyruvate content and enhance heat stress resistance in Ganoderma lucidum
    Year 2025
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    Year 2024
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  • Nicotinamide enhances Treg differentiation by promoting Foxp3 acetylation in immune thrombocytopenia
    Year 2024
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  • Inhibition of HDAC8 mitigates AKI by reducing DNA damage and promoting homologous recombination repair
    Year 2024
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    Reactivity
  • Calotropin attenuates ischemic heart failure after myocardial infarction by modulating SIRT1/FOXD3/SERCA2a pathway
    Year 2024
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    Reactivity
  • MOF-mediated acetylation of CDK9 promotes global transcription by modulating P-TEFb complex formation
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  • Hexokinase HK3-mediated O-GlcNAcylation of EP300: a key regulator of PD-L1 expression and immune evasion in ccRCC
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  • Targeting the transmembrane cytokine co-receptor neuropilin-1 in distal tubules improves renal injury and fibrosis
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