Clone Number: 11447
Host: Mouse Clonality: Recombinant Monoclonal
Applications： FC
Reactivity: Human
Synonyms: Lymphocyte antigen 64, Radioprotective 105 kDa protein, CD180 antigen
Shipping: Ambient temperature
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| Isotype | IgG1 |
| Conjugate | Unconjugated |
| Synonyms | Lymphocyte antigen 64, Radioprotective 105 kDa protein, CD180 antigen |
| UniProt ID | |
| Immunogen | |
| MW (kDa) | |
| Specificity |
| Applications | Dilution | Recommended Species |
|---|---|---|
| FC | 1:50 - 1:100 | Human |
| Purity | Protein A purified |
| Constituents | PBS, Glycerol, BSA |
| Storage | Store at -20°C. Avoid freeze/thaw cycles. |
| Stability | Stable for 12 months from date of receipt/reconstitution. |
Background
CD180/RP105 is a type-I transmembrane glycoprotein that is restricted to expression in mature B-cells. Research studies have shown that CD180 engages signaling cascades in mature B-cells that drive cell proliferation. Indeed, CD180 functions with TLR4 as an LPS receptor on B-cells and, upon binding LPS, transmits proliferation and survival signals that require the Vav family of guanine nucleotide exchange factors.
Cellular location
Membrane
| FC | |
|---|---|
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specimen: Human peripheral blood lymphocytes |
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Cell line: HeLa (Negative cell line) |
Research Use
For research use only, not for use in diagnostic procedures.
