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Hypoxic Reprogramming of ACOX1-Driven HSP90AB1 Crotonylation Stabilizes Thioredoxin to Orchestrate Redox Homeostasis in Oral Squamous Cell Carcinoma
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Year
2026
-
Journal
Research
-
Authors
Xiteng Yin, et al.
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Applications
Unspecified
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Reactivity
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Lysine malonylation regulates human sperm motility
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Year
2026
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Journal
Communications Biology
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Authors
Cheng Yimin, et al.
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Applications
Unspecified
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Reactivity
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Lysine crotonylation of fungal effectors enhances their activity to promote fungal invasion of host plants
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Year
2025
-
Journal
Plant Communications
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Authors
Ning Zhang, et al.
-
Applications
Unspecified
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Reactivity
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Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression
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Year
2025
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Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
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Authors
Pan Yani, et al.
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Applications
Unspecified
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Reactivity
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DDX1 Crotonylation Mediates ACOX1 Alternative Splicing through HNRNPK to Increase Peroxisomal Oxidative Damage
-
Year
2025
-
Journal
FREE RADICAL BIOLOGY AND MEDICINE
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Authors
Jiansong Liu, et al.
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Applications
Unspecified
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Reactivity
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Protein Lysine Crotonylation Analysis Reveals an Important Role in the Regulation of Aeromonas hydrophila Maltose Transport
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Year
2025
-
Journal
JOURNAL OF PROTEOME RESEARCH
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Authors
Yuying Fu, et al.
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Applications
Unspecified
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Reactivity
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YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness
-
Year
2025
-
Journal
Cell Reports
-
Authors
Zijun Peng, et al.
-
Applications
Unspecified
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Reactivity
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Multi-dimensional epigenomic dynamics converge on H3K4 regulation of low CO2 adaptation in Nannochloropsis oceanica
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Year
2025
-
Journal
Plant Communications
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Authors
Yanhai Gong, et al.
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Applications
Unspecified
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Reactivity
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O-GlcNAcylated Hsp47 as a predictive biomarker in colorectal cancer: Kaempferol targets OGT-collagen axis for therapeutic intervention
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Year
2025
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Journal
International Journal of Biological Sciences
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Authors
Chishun Zhou, et al.
-
Applications
Unspecified
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Reactivity
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ACSS2-Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7
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Year
2025
-
Journal
Advanced Science
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Authors
Ming Yuan, et al.
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Applications
Unspecified
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Reactivity
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The role of CddA and cGNAT2 in crotonylation of proteins in cyanobacteria
-
Year
2025
-
Journal
NEW PHYTOLOGIST
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Authors
Jian Lin, et al.
-
Applications
Unspecified
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Reactivity
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Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells
-
Year
2025
-
Journal
ACS Chemical Biology
-
Authors
Xinlong Guo, et al.
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Applications
Unspecified
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Reactivity
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Crotonylation driving Streptococcus pneumoniae adaption and virulence
-
Year
2025
-
Journal
Journal of Advanced Research
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Authors
Nan Li, et al.
-
Applications
Unspecified
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Reactivity
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Risk stratification and prognosis determination based on protein lysine crotonylation in patients with resected pancreatic cancer: A multicenter study
-
Year
2025
-
Journal
CLINICAL CANCER RESEARCH
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Authors
Cao Lianjing, et al.
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Applications
Unspecified
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Reactivity
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The YEATS domain is a selective reader of histone methacrylation
-
Year
2025
-
Journal
STRUCTURE
-
Authors
Dustin C. Becht, et al.
-
Applications
Unspecified
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Reactivity
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Crotonylation deficiency of S100A7 K49 promotes psoriatic keratinocyte proliferation through enhanced interaction with RAGE
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Year
2025
-
Journal
Scientific Reports
-
Authors
Liang Huifang, et al.
-
Applications
Unspecified
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Reactivity
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Dynamic interaction of MYC enhancer RNA with YEATS2 protein regulates MYC gene transcription in pancreatic cancer
-
Year
2025
-
Journal
EMBO REPORTS
-
Authors
RoyJayita , et al.
-
Applications
Unspecified
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Reactivity
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Sodium butyrate attenuates liver fibrogenesis via promoting H4K8 crotonylation
-
Year
2025
-
Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
-
Authors
Tang Ruiqi, et al.
-
Applications
Unspecified
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Reactivity
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PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms
-
Year
2025
-
Journal
Cell Reports
-
Authors
Qiaoxi Xia, et al.
-
Applications
Unspecified
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Reactivity
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Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis
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Year
2025
-
Journal
Nature Communications
-
Authors
Wang Meng, et al.
-
Applications
Unspecified
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Reactivity
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Histone Lysine Crotonylation Accelerates ACSL4-Mediated Ferroptosis of Keratinocytes via Modulating Autophagy in Diabetic Wound Healing
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Year
2025
-
Journal
PHARMACOLOGICAL RESEARCH
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Authors
Fengjuan Li, et al.
-
Applications
Unspecified
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Reactivity
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Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
-
Year
2025
-
Journal
CELL RESEARCH
-
Authors
Zhao Qihang, et al.
-
Applications
Unspecified
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Reactivity
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Fasting-Mimicking Diet Prevents Pancreatic Carcinogenesis via Gut Microbiota and Metabolites
-
Year
2024
-
Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
-
Authors
Huaxin Li, et al.
-
Applications
Unspecified
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Reactivity
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PTBP1 crotonylation promotes colorectal cancer progression through alternative splicing-mediated upregulation of the PKM2 gene
-
Year
2024
-
Journal
Journal of Translational Medicine
-
Authors
Hou Jia-Yi, et al.
-
Applications
Unspecified
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Reactivity
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Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle
-
Year
2024
-
Journal
Nature Communications
-
Authors
Guo Zihao, et al.
-
Applications
Unspecified
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Reactivity
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Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation
-
Year
2024
-
Journal
Cell Reports
-
Authors
Hongchun Li, et al.
-
Applications
Unspecified
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Reactivity
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Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation
-
Year
2024
-
Journal
Theranostics
-
Authors
Xiao-Yi Xiong, et al.
-
Applications
Unspecified
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Reactivity
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p53 deficiency mediates cisplatin resistance by upregulating RRM2 and crotonylation of RRM2K283 through the downregulation of SIRT7
-
Year
2024
-
Journal
Frontiers in Molecular Biosciences
-
Authors
Sun Liangjie, et al.
-
Applications
Unspecified
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Reactivity
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Sodium Crotonate Alleviates Diabetic Kidney Disease Partially Via the Histone Crotonylation Pathway
-
Year
2024
-
Journal
INFLAMMATION
-
Authors
He Yanqiu, et al.
-
Applications
Unspecified
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Reactivity
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SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1
-
Year
2024
-
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
-
Authors
Jin Xinxin, et al.
-
Applications
Unspecified
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Reactivity
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Lysine catabolism reprograms tumour immunity through histone crotonylation
-
Year
2023
-
Journal
NATURE
-
Authors
Yuan Huairui, et al.
-
Applications
Unspecified
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Reactivity
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Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner
-
Year
2023
-
Journal
CELL RESEARCH
-
Authors
Liao Long, et al.
-
Applications
Unspecified
-
Reactivity
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Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner
-
Year
2023
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
-
Authors
Mengxia Qu, et al.
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Applications
Unspecified
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Reactivity
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The short-chain fatty acid crotonate reduces invasive growth and immune escape of Candida albicans by regulating hyphal gene expression
-
Year
2023
-
Journal
mBio
-
Authors
Christopher McCrory, et al.
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Applications
Unspecified
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Reactivity
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Histone crotonylation of peripheral blood mononuclear cells is a potential biomarker for diagnosis of colorectal cancer
-
Year
2023
-
Journal
Epigenetics & Chromatin
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Authors
Hou Jia-Yi, et al.
-
Applications
Unspecified
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Reactivity
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Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression
-
Year
2023
-
Journal
Cell Reports
-
Authors
Yan Zheng, et al.
-
Applications
Unspecified
-
Reactivity
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Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner
-
Year
2023
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
-
Authors
Mengxia Qu, et al.
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Applications
Unspecified
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Reactivity
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Crotonylation of GAPDH regulates human embryonic stem cell endodermal lineage differentiation and metabolic switch
-
Year
2023
-
Journal
Stem Cell Research & Therapy
-
Authors
Zhang Jingran, et al.
-
Applications
Unspecified
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Reactivity
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Sodium butyrate mediates histone crotonylation and alleviated neonatal rats hypoxic-ischemic brain injury through gut-brain axis.
-
Year
2022
-
Journal
Frontiers in Microbiology
-
Authors
Xuejia He, et al.
-
Applications
Unspecified
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Reactivity
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Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease
-
Year
2022
-
Journal
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
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Authors
Dang Lin, et al.
-
Applications
Unspecified
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Reactivity
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Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer
-
Year
2022
-
Journal
Cell Death & Disease
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Authors
Zhang Dan, et al.
-
Applications
Unspecified
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Reactivity
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Regulation of Cellular Metabolism by Protein Crotonylation Coordinates Pancreatic Cancer Progression
-
Year
2022
-
Journal
Cell Reports
-
Authors
Zheng Yan, et al.
-
Applications
Unspecified
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Reactivity
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Involvement of Histone Lysine Crotonylation in the Regulation of Nerve-Injury-Induced Neuropathic Pain
-
Year
2022
-
Journal
Frontiers in Immunology
-
Authors
Yu Zou, et al.
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Applications
Unspecified
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Reactivity
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Sorafenib Attenuates Fibrotic Hepatic Injury Through Mediating Lysine Crotonylation
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Year
2022
-
Journal
Drug Design Development and Therapy
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Authors
Xiao-Feng Chen, et al.
-
Applications
Unspecified
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Reactivity
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CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
-
Year
2022
-
Journal
MOLECULAR CELL
-
Authors
Enas R. Abu-Zhayia, et al.
-
Applications
Unspecified
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Reactivity
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Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice
-
Year
2022
-
Journal
Cell Death & Disease
-
Authors
Zhang Yuan, et al.
-
Applications
Unspecified
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Reactivity
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Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
-
Year
2022
-
Journal
Science Advances
-
Authors
Carlos Moreno-Yruela, et al.
-
Applications
Unspecified
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Reactivity
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The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum
-
Year
2021
-
Journal
eLife
-
Authors
Ning Zhang, et al.
-
Applications
Unspecified
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Reactivity
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Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis
-
Year
2021
-
Journal
Nature Chemical Biology
-
Authors
Song Xiaoyu, et al.
-
Applications
Unspecified
-
Reactivity
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LncRNA NEAT1 induces autophagy through epigenetic regulation of autophagy-related gene expression in neuroglial cells
-
Year
2021
-
Journal
JOURNAL OF CELLULAR PHYSIOLOGY
-
Authors
Ziqiang Wang, et al.
-
Applications
Unspecified
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Reactivity
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Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies
-
Year
2021
-
Journal
Scientific Reports
-
Authors
Kollenstart Leonie, et al.
-
Applications
Unspecified
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Reactivity
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Tsga8 is required for spermatid morphogenesis and male fertility in mice
-
Year
2021
-
Journal
DEVELOPMENT
-
Authors
Yuki Kobayashi, et al.
-
Applications
Unspecified
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Reactivity
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Global Profiling of the Lysine Crotonylome in Different Pluripotent States
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Year
2021
-
Journal
GENOMICS PROTEOMICS & BIOINFORMATICS
-
Authors
Yuan Lv, et al.
-
Applications
Unspecified
-
Reactivity
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Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells
-
Year
2021
-
Journal
Cell Stem Cell
-
Authors
Yi Fang, et al.
-
Applications
Unspecified
-
Reactivity
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Comprehensive identification of lysine 2-hydroxyisobutyrylated proteins in Ustilaginoidea virens reveals the involvement of lysine 2-hydroxyisobutyrylation in fungal virulence
-
Year
2021
-
Journal
Journal of Integrative Plant Biology
-
Authors
Xiaoyang Chen, et al.
-
Applications
Unspecified
-
Reactivity
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p300-Catalyzed Lysine Crotonylation Promotes the Proliferation, Invasion, and Migration of HeLa Cells via Heterogeneous Nuclear Ribonucleoprotein A1
-
Year
2020
-
Journal
Analytical Cellular Pathology
-
Authors
Xuesong Han, et al.
-
Applications
Unspecified
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Reactivity
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Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus
-
Year
2020
-
Journal
Communications Biology
-
Authors
Sun Chen-Fan, et al.
-
Applications
Unspecified
-
Reactivity
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The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen
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Year
2020
-
Journal
Cell Reports
-
Authors
Qi Wang, et al.
-
Applications
Unspecified
-
Reactivity
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Crotonylation at serine 46 impairs p53 activity
-
Year
2020
-
Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
-
Authors
Peng Liao, et al.
-
Applications
Unspecified
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Reactivity
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Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription
-
Year
2019
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
-
Authors
Leonie Kollenstart, et al.
-
Applications
Unspecified
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Reactivity
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Lysine glutarylation in human sperm is associated with progressive motility
-
Year
2019
-
Journal
HUMAN REPRODUCTION
-
Authors
Cheng Yi-min, et al.
-
Applications
Unspecified
-
Reactivity
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NEAT1 regulates neuroglial cell mediating Aβ clearance via the epigenetic regulation of endocytosis-related genes expression
-
Year
2019
-
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
-
Authors
Wang Ziqiang, et al.
-
Applications
Unspecified
-
Reactivity
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MiR-155-5p modulates HSV-1 replication via the epigenetic regulation of SRSF2 gene expression
-
Year
2019
-
Journal
Epigenetics
-
Authors
Ziqiang Wang, et al.
-
Applications
Unspecified
-
Reactivity
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HDAC-dependent decrease in histone crotonylation during DNA damage
-
Year
2019
-
Journal
Journal of Molecular Cell Biology
-
Authors
Abu-Zhayia Enas R, et al.
-
Applications
Unspecified
-
Reactivity
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Investigation of the Developmental Requirements of Drosophila HP1 and Insulator Protein Partner, HIPP1
-
Year
2019
-
Journal
G3-Genes Genomes Genetics
-
Authors
Glenn Steve E, et al.
-
Applications
Unspecified
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Reactivity
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Lysine crotonylation is involved in hepatocellular carcinoma progression
-
Year
2019
-
Journal
BIOMEDICINE & PHARMACOTHERAPY
-
Authors
Junhu Wan, et al.
-
Applications
Unspecified
-
Reactivity
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Dynamics and functional interplay of histone lysine butyrylation, crotonylation, and acetylation in rice under starvation and submergence
-
Year
2018
-
Journal
GENOME BIOLOGY
-
Authors
Lu Yue, et al.
-
Applications
Unspecified
-
Reactivity
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Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster
-
Year
2018
-
Journal
PLoS One
-
Authors
Tim Hundertmark, et al.
-
Applications
Unspecified
-
Reactivity
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Global Involvement of Lysine Crotonylation in Protein Modification and Transcription Regulation in Rice
-
Year
2018
-
Journal
MOLECULAR & CELLULAR PROTEOMICS
-
Authors
Shuai Liu, et al.
-
Applications
Unspecified
-
Reactivity
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Quantitative Crotonylome Analysis Expands the Roles of p300 in the Regulation of Lysine Crotonylation Pathway
-
Year
2018
-
Journal
PROTEOMICS
-
Authors
He Huang, et al.
-
Applications
Unspecified
-
Reactivity
-
p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis
-
Year
2018
-
Journal
MOLECULAR CELL
-
Authors
He Huang, et al.
-
Applications
Unspecified
-
Reactivity
-
First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos
-
Year
2018
-
Journal
Scientific Reports
-
Authors
Kwon Oh Kwang, et al.
-
Applications
Unspecified
-
Reactivity
-
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
-
Year
2018
-
Journal
Nature Communications
-
Authors
Fellows Rachel, et al.
-
Applications
Unspecified
-
Reactivity
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Characterization of histone acylations links chromatin modifications with metabolism
-
Year
2017
-
Journal
Nature Communications
-
Authors
Simithy Johayra, et al.
-
Applications
Unspecified
-
Reactivity
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Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis
-
Year
2017
-
Journal
MOLECULAR CELL
-
Authors
Shumeng Liu, et al.
-
Applications
Unspecified
-
Reactivity
-
MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300
-
Year
2017
-
Journal
Cell Discovery
-
Authors
Liu Xiaoguang, et al.
-
Applications
Unspecified
-
Reactivity
-
Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription
-
Year
2017
-
Journal
CELL RESEARCH
-
Authors
Wei Wei, et al.
-
Applications
Unspecified
-
Reactivity
-
Large-Scale Identification of Protein Crotonylation Reveals Its Role in Multiple Cellular Functions
-
Year
2017
-
Journal
JOURNAL OF PROTEOME RESEARCH
-
Authors
Wei Wei, et al.
-
Applications
Unspecified
-
Reactivity
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Histone lysine crotonylation during acute kidney injury in mice
-
Year
2016
-
Journal
Disease Models & Mechanisms
-
Authors
Olga Ruiz-Andres, et al.
-
Applications
Unspecified
-
Reactivity
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Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline
-
Year
2015
-
Journal
BMC BIOLOGY
-
Authors
Sin Ho-Su, et al.
-
Applications
Unspecified
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Reactivity
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Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation
-
Year
2015
-
Journal
MOLECULAR CELL
-
Authors
Benjamin R. Sabari, et al.
-
Applications
Unspecified
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Reactivity
-
Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark
-
Year
2014
-
Journal
Nature Chemical Biology
-
Authors
Dai Lunzhi, et al.
-
Applications
Unspecified
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Reactivity
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RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids
-
Year
2012
-
Journal
GENES & DEVELOPMENT
-
Authors
Ho-Su Sin, et al.
-
Applications
Unspecified
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Reactivity
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Site-Specific Incorporation of ε-N-Crotonyllysine into Histones
-
Year
2012
-
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
-
Authors
Chan Hyuk Kim, et al.
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Applications
Unspecified
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Reactivity
