Background
EXOC3L2 (Exocyst complex component 3-like 2) is a protein that is encoded by the EXOC3L2 gene in human. The EXOC3L2 protein has been shown to interact with EXOC4 that is a component of the exocyst complex involved exocytosis and more specifically in the targeting of exocytic vesicles to the cell membrane. The exocyst complex is important for several biological processes, such as the establishment of cell polarity and regulation of cell migration. The structure and functions of the exocyst complex are conserved from yeast to higher eukaryotes. Endothelial cells in blood vessels express high levels of EXOC3L2 that is required for proper VEGFR-2 signaling so that the endothelial cells can migrate towards the growth factor VEGF-A.
Cellular location
Nucleus, Cytoplasm