Background
HP1 gamma (HP1γ) is a member of Heterochromatin protein 1 (HP1) family, which is involved in both gene silencing and higher order chromatin structure. All three HP1 family members (α, β, and γ) are primarily associated with centromeric heterochromatin; however, HP1β and γ also localize to euchromatic sites in the genome. HP1 proteins are approximately 25 kDa in size and contain a conserved amino-terminal chromodomain, followed by a variable hinge region and a conserved carboxy-terminal chromoshadow domain. The chromodomain facilitates binding to histone H3 Trimethylated at Lys9, a histone "mark" closely associated with centromeric heterochromatin.
Cellular location
Nucleus