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Recombinant Rabbit Monoclonal
Anti-L-Lactyl-Histone H3 (Lys18) Rabbit mAb (ChIP Grade)
Catalog Number: PTM-1427RM
References (77)
$ 435

Clone Number: PAPTM-599-16

Host: Rabbit Clonality: Recombinant Monoclonal

Applications： WB ChIP CUT&Tag

Reactivity: Human, Mouse

Synonyms: H3K18la

Product Size
100 μl
Quantity

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms H3K18la
UniProt ID

P68431

Immunogen L-lactylated human histone H3 (Lys18) peptide
MW (kDa) 15
Specificity Anti-L-Lactyl-Histone H3 (Lys18) Rabbit mAb (ChIP Grade) detects histone H3 only when it is L-lactylated at Lys18.
Product Usage Information
Applications Dilution Recommended Species
WB 1:500 - 1:1000 Human, Mouse
ChIP 6 μg per 5×106 cells Human, Mouse
CUT&Tag 1:100 Human
Properties
Purity Protein A purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

Histones, fundamental proteins involved in chromatin structure and gene regulation, are subject to a wide array of enzyme-catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, and numerous others. Histone L-lactylation, a recently discovered post-translational modification induced by lactate has emerged as a significant addition to this repertoire. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The introduction of lysine L-lactylation is mediated by the acetyltransferase p300, while the removal of lactylation marks from histones has been attributed to Class I histone deacetylases (HDAC 1-3). Histone lactylation has been implicated in various biological processes, including inflammation, fibrosis, differentiation, and cancer progression.

Cellular location

Nucleus

Images
Dot Blot

Peptide amount: 4 ng, 16 ng, 64 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 10 seconds
The list of peptides used in the experiment is provided below.
Lane 1: H3K18 L-lactyl. Lane 2: H3K18 acetyl.
Lane 3: H3K18 crotonyl. Lane 4: H3K18 butyryl.
Lane 5: H3K18 propionyl. Lane 6: H3K18 2-hydroxyisobutyryl.
Lane 7: H3K18 β-hydroxybutyryl. Lane 8: H3K18 unmodified
WB

Lysates: (-) HeLa cells; (+) HeLa cells treated with 25 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa

Lysates: (-) K562 cells; (+) K562 cells treated with 25 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa

Lysates: (-) NIH/3T3 cells; (+) NIH/3T3 cells treated with 25 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa
ChIP

Sample: HeLa cells treated with 100 mM sodium lactate for 24 hours
Cross-linking conditions: no cross-linking
Amount of chromatin per IP: 5×106 cells
Amount of Ab per IP: 6 μg
Beads type and amount per IP: 50 μL of Protein A MagBeads
Description: Chromatin immunoprecipitations were performed with 6 μg of normal rabbit IgG as a negative control. The immunoprecipitated DNA was quantified by real-time PCR using primers specific for the human GAPDH-CDS, LDHA promoter, LDHA, FOXO3a downstream, RAB20, and TUBBP10 regions. The data are presented as enrichment of each sample relative to the total amount of input at each amplicon.
CUT&Tag

Sample: HeLa cells treated with 100 mM sodium lactate for 24 hours
Cell quantity: 1×105 cells
Primary Ab dilution: 1:100
Primary Ab incubation: 4⁰C overnight
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (PTM-6252)
Secondary Ab dilution: 1:1400
Description: CUT&Tag was performed with Anti-L-Lactyl-Histone H3 (Lys18) Rabbit mAb (PTM-1427RM) alongside normal rabbit IgG as a negative control. The resulting DNA was sequenced on the Illumina NovaSeq platform with paired-end reads of 150 bp and a sequencing depth of 3 million reads. The figure shows significant H3K18la signal enrichments at the promoter regions of CD9, PLEKHG6, LTBR, and GAPDH.

Research Use

For research use only, not for use in diagnostic procedures.

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References (77)
  • H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury
    Year 2026
    Journal Theranostics
    Authors Yan Huang, et al.
    Applications Unspecified
    Reactivity
  • PDP1 drives hepatocellular carcinoma progression by regulating senescence through the cAMP/Ca2+ signaling pathway
    Year 2026
    Journal BIOCHEMICAL PHARMACOLOGY
    Authors Jiamin Xie, et al.
    Applications Unspecified
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  • Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion
    Year 2026
    Journal Theranostics
    Authors Jiangli Zhao, et al.
    Applications Unspecified
    Reactivity
  • Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression
    Year 2026
    Journal Cell Death & Disease
    Authors Yang Shizhou, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression
    Year 2026
    Journal LIFE SCIENCES
    Authors Mingxing Sui, et al.
    Applications Unspecified
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  • Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation
    Year 2026
    Journal INFLAMMATION
    Authors Wang Ziqian, et al.
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  • Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression
    Year 2026
    Journal Frontiers in Immunology
    Authors Wenxin Da, et al.
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  • Lipopolysaccharide-induced histone lactylation mediates m6A RNA modification causing mitochondrial dysfunction and pulmonary fibroblasts activation to exacerbate sepsis-associated pulmonary fibrosis
    Year 2025
    Journal RESPIRATORY RESEARCH
    Authors Tang Ri, et al.
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  • Helicobacter pylori infection aggravates hepatic steatosis by lactylation-driven WTAP-mediated m6A modification
    Year 2025
    Journal Gut Microbes
    Authors Han Chen, et al.
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  • Histone H3 lysine 18 lactylation promotes alveolar epithelial cell apoptosis in sepsis-induced lung injury by upregulating caspase-8 in vivo and in vitro
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    Journal EXPERIMENTAL CELL RESEARCH
    Authors Ping Lin, et al.
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  • H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2+ Treg recruitment
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    Journal EXPERIMENTAL AND MOLECULAR MEDICINE
    Authors Ye Linlin, et al.
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  • A metabolic reprogramming and trained immunity hydrogel mimic cluster missiles to eliminate infection and treat infected diabetic wounds
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    Authors Yu Zirui, et al.
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  • Mesenchymal Stem Cell-Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation
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    Authors Qiang Huang, et al.
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  • lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation
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    Journal Molecular Medicine Reports
    Authors Li Yu, et al.
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  • Histone lactylation contributes to neuropathic pain by facilitating m6A reader protein IGF2BP2 expression in DRG sensory neurons
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    Journal JOURNAL OF NEUROSCIENCE
    Authors Qi-Hui Wang, et al.
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  • Histone lactylation-induced GLI3 activation drives macrophage M1 polarization and exosomal SERPINE1 release in abdominal aortic aneurysm progression
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    Journal Cell Death Discovery
    Authors Yuan Kai, et al.
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  • Mitophagy Reprograms Lactate Metabolism to Suppress THBS1 via H3K18la Reduction, Alleviating Intervertebral Disc Degeneration
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    Journal Research
    Authors Kanbin Wang, et al.
    Applications Unspecified
    Reactivity
  • Histone H3K18 lactylation-dependent epigenetic activation of RUNX2 orchestrates PI3K/AKT oncogenic signaling in laryngeal squamous cell carcinoma
    Year 2025
    Journal JOURNAL OF MOLECULAR HISTOLOGY
    Authors Fu Daidi, et al.
    Applications Unspecified
    Reactivity
  • Structural characterization and anti-hepatic fibrosis effects of a novel polysaccharide from Astragalus complanatus seeds
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    Journal CARBOHYDRATE POLYMERS
    Authors Zhi-Fan Zhu, et al.
    Applications Unspecified
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  • H3K18 lactylation potentiates microglial polarization via the TLR4 pathway in diabetes-induced cognitive impairment
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    Journal JCI Insight
    Authors Ying Yang, et al.
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  • Lactylation-induced ALKBH5 targets RNF123 to worsen retinal Müller cell activation through PKM2-regulated Glycolysis in diabetic retinopathy
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    Authors Luo Shasha, et al.
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    Authors Weijing Fan, et al.
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    Authors Jinna Li, et al.
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    Authors Huang Fan, et al.
    Applications Unspecified
    Reactivity
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    Authors Li Bo, et al.
    Applications Unspecified
    Reactivity
  • Neddylation inhibitor MLN4924 enhances H3K18 lactylation via binding to LDH and downregulates ITGB4 to block metastasis
    Year 2025
    Journal JOURNAL OF BIOLOGICAL CHEMISTRY
    Authors Hongfei Yu, et al.
    Applications Unspecified
    Reactivity
  • Global profiling of protein lactylome in porcine granulosa cells
    Year 2025
    Journal Journal of Ovarian Research
    Authors Fan Shuhao, et al.
    Applications Unspecified
    Reactivity
  • Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1
    Year 2025
    Journal Journal of Advanced Research
    Authors Zhihao Liu, et al.
    Applications Unspecified
    Reactivity
  • Chronic intermittent hypoxia impairs BM-MSC osteogenesis and long bone growth through regulating histone lactylation
    Year 2025
    Journal Journal of Translational Medicine
    Authors Chen Fang, et al.
    Applications Unspecified
    Reactivity
  • Crizotinib: A Novel Strategy to Reverse Immunosuppression in Melanoma by Targeting Lactate Transport
    Year 2025
    Journal MedComm
    Authors Zhe Zhou, et al.
    Applications Unspecified
    Reactivity
  • H3K18 lactylation drives the progression of silica nanoparticles-induced pulmonary fibrosis via promoting macrophage M1 polarization
    Year 2025
    Journal JOURNAL OF HAZARDOUS MATERIALS
    Authors Lili Shi, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes collagen expression, proliferation and migration through H3K18 lactylation-dependent stimulation of LTBP3/TGF-β1 axis in keloid fibroblasts
    Year 2025
    Journal JOURNAL OF INVESTIGATIVE DERMATOLOGY
    Authors Jing-Jing Gu, et al.
    Applications Unspecified
    Reactivity
  • Demethylzeylasteral suppresses the expression of MESP1 by reducing H3K18la level to inhibit the malignant behaviors of pancreatic cancer
    Year 2025
    Journal Cell Death Discovery
    Authors Ma Xiaolei, et al.
    Applications Unspecified
    Reactivity
  • Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells
    Year 2025
    Journal ACS Chemical Biology
    Authors Xinlong Guo, et al.
    Applications Unspecified
    Reactivity
  • Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neurons
    Year 2025
    Journal Science Signaling
    Authors Yu-Tao Deng, et al.
    Applications Unspecified
    Reactivity
  • Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway
    Year 2025
    Journal Advanced Science
    Authors Zongwen Liang, et al.
    Applications Unspecified
    Reactivity
  • WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma
    Year 2025
    Journal Advanced Science
    Authors Tao Huang, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation-induced premature senescence contributes to 1-nitropyrene-Induced chronic obstructive pulmonary disease
    Year 2025
    Journal Redox Biology
    Authors Rong-Rong Wang, et al.
    Applications Unspecified
    Reactivity
  • Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
    Year 2025
    Journal Signal Transduction and Targeted Therapy
    Authors She Han, et al.
    Applications Unspecified
    Reactivity
  • IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy
    Year 2025
    Journal CELLULAR AND MOLECULAR LIFE SCIENCES
    Authors Hu Xiaofang, et al.
    Applications Unspecified
    Reactivity
  • The effect of lactate dehydrogenase B and its mediated histone lactylation on chondrocyte ferroptosis during osteoarthritis
    Year 2025
    Journal Journal of Orthopaedic Surgery and Research
    Authors Zhang Yang, et al.
    Applications Unspecified
    Reactivity
  • Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory
    Year 2025
    Journal CELL
    Authors Athanasios Ziogas, et al.
    Applications Unspecified
    Reactivity
  • The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance
    Year 2025
    Journal Journal of Gastrointestinal Oncology
    Authors Kunli Zhu, et al.
    Applications Unspecified
    Reactivity
  • ChIP-seq and RNA-seq Reveal the Involvement of Histone Lactylation Modification in Early Pregnancy with Subclinical Hypothyroidism
    Year 2025
    Journal BIOCHEMICAL GENETICS
    Authors Cheng Chaofei, et al.
    Applications Unspecified
    Reactivity
  • H3K9/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells
    Year 2025
    Journal TOXICOLOGY AND APPLIED PHARMACOLOGY
    Authors Xiaomin Xie, et al.
    Applications Unspecified
    Reactivity
  • Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression
    Year 2025
    Journal Journal of Translational Medicine
    Authors Liu Jinlin, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation regulates early embryonic development through m6A methyltransferase METTL3 in goats
    Year 2025
    Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
    Authors Dongxu Li, et al.
    Applications Unspecified
    Reactivity
  • Glycolysis Induces Abnormal Transcription Through Histone Lactylation in T-lineage Acute Lymphoblastic Leukemia
    Year 2025
    Journal GENOMICS PROTEOMICS & BIOINFORMATICS
    Authors Wu Wenyan, et al.
    Applications Unspecified
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  • Gastrodin attenuates rheumatoid arthritis by targeting KAT8 to inhibit the lactylation of H3K9
    Year 2025
    Journal Frontiers in Pharmacology
    Authors Yufang Dai, et al.
    Applications Unspecified
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  • METTL3 regulated by histone lactylation promotes ossification of the ligamentum flavum by enhancing the m6A methylation of BMP2
    Year 2025
    Journal MOLECULAR MEDICINE
    Authors Jiaming Zhou, et al.
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  • Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury
    Year 2025
    Journal Autophagy
    Authors Lei Xu, et al.
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  • H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition (EMT) of airway epithelial cells
    Year 2025
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    Authors Songtao Liu, et al.
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  • H4K12 lactylation potentiates mitochondrial oxidative stress via the Foxo1 pathway in diabetes-induced cognitive impairment
    Year 2025
    Journal Journal of Advanced Research
    Authors Ying Yang, et al.
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  • Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation
    Year 2025
    Journal Redox Biology
    Authors Jiayan Huang, et al.
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  • Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation-Mediated FGFR4 Activation
    Year 2025
    Journal Advanced Science
    Authors Zehua Ye, et al.
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  • Organoid modeling identifies USP3-AS1 as a novel promoter in colorectal cancer liver metastasis through increasing glucose-driven histone lactylation
    Year 2025
    Journal ACTA PHARMACOLOGICA SINICA
    Authors Zhou Jia-min, et al.
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  • Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson’s disease via histone lactylation
    Year 2025
    Journal npj Parkinsons Disease
    Authors Qin Qixiong, et al.
    Applications Unspecified
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  • Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury
    Year 2024
    Journal Advanced Science
    Authors Zongqing Lu, et al.
    Applications Unspecified
    Reactivity
  • DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation
    Year 2024
    Journal Journal of Molecular Cell Biology
    Authors Yang Yaqi, et al.
    Applications Unspecified
    Reactivity
  • Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis
    Year 2024
    Journal PHYTOMEDICINE
    Authors Tianya Xiang, et al.
    Applications Unspecified
    Reactivity
  • Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
    Year 2024
    Journal Cell Metabolism
    Authors Ruilong Liu, et al.
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