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Recombinant Rabbit Monoclonal
Anti-L-Lactyl-Histone H3 (Lys18) Rabbit mAb (ChIP Grade)
Catalog Number: PTM-1427RM
References (88)
$ 435

Clone Number: PAPTM-599-16

Host: Rabbit Clonality: Recombinant Monoclonal

Applications： WB ChIP CUT&Tag

Reactivity: Human, Mouse

Synonyms: H3K18la

Product Size
100μl
Quantity

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms H3K18la
UniProt ID

P68431

Immunogen L-lactylated human histone H3 (Lys18) peptide
MW (kDa) 15
Specificity Anti-L-Lactyl-Histone H3 (Lys18) Rabbit mAb (ChIP Grade) detects histone H3 only when it is L-lactylated at Lys18.
Product Usage Information
Applications Dilution Recommended Species
WB 1:500 - 1:1000 Human, Mouse
ChIP 6 μg per 5×106 cells Human, Mouse
CUT&Tag 1:100 Human
Properties
Purity Protein A purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

Histones, fundamental proteins involved in chromatin structure and gene regulation, are subject to a wide array of enzyme-catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, and numerous others. Histone L-lactylation, a recently discovered post-translational modification induced by lactate has emerged as a significant addition to this repertoire. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The introduction of lysine L-lactylation is mediated by the acetyltransferase p300, while the removal of lactylation marks from histones has been attributed to Class I histone deacetylases (HDAC 1-3). Histone lactylation has been implicated in various biological processes, including inflammation, fibrosis, differentiation, and cancer progression.

Cellular location

Nucleus

Images
Dot Blot

Peptide amount: 4 ng, 16 ng, 64 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 10 seconds
The list of peptides used in the experiment is provided below.
Lane 1: H3K18 L-lactyl. Lane 2: H3K18 acetyl.
Lane 3: H3K18 crotonyl. Lane 4: H3K18 butyryl.
Lane 5: H3K18 propionyl. Lane 6: H3K18 2-hydroxyisobutyryl.
Lane 7: H3K18 β-hydroxybutyryl. Lane 8: H3K18 unmodified
WB

Lysates: (-) HeLa cells; (+) HeLa cells treated with 25 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa

Lysates: (-) K562 cells; (+) K562 cells treated with 25 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa

Lysates: (-) NIH/3T3 cells; (+) NIH/3T3 cells treated with 25 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa
ChIP

Sample: HeLa cells treated with 100 mM sodium lactate for 24 hours
Cross-linking conditions: no cross-linking
Amount of chromatin per IP: 5×106 cells
Amount of Ab per IP: 6 μg
Beads type and amount per IP: 50 μL of Protein A MagBeads
Description: Chromatin immunoprecipitations were performed with 6 μg of normal rabbit IgG as a negative control. The immunoprecipitated DNA was quantified by real-time PCR using primers specific for the human GAPDH-CDS, LDHA promoter, LDHA, FOXO3a downstream, RAB20, and TUBBP10 regions. The data are presented as enrichment of each sample relative to the total amount of input at each amplicon.
CUT&Tag

Sample: HeLa cells treated with 100 mM sodium lactate for 24 hours
Cell quantity: 1×105 cells
Primary Ab dilution: 1:100
Primary Ab incubation: 4⁰C overnight
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (PTM-6252)
Secondary Ab dilution: 1:1400
Description: CUT&Tag was performed with Anti-L-Lactyl-Histone H3 (Lys18) Rabbit mAb (PTM-1427RM) alongside normal rabbit IgG as a negative control. The resulting DNA was sequenced on the Illumina NovaSeq platform with paired-end reads of 150 bp and a sequencing depth of 3 million reads. The figure shows significant H3K18la signal enrichments at the promoter regions of CD9, PLEKHG6, LTBR, and GAPDH.

Research Use

For research use only, not for use in diagnostic procedures.

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References (88)
  • H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury
    Year 2026
    Journal Theranostics
    Authors Yan Huang, et al.
    Applications Unspecified
    Reactivity
  • Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion
    Year 2026
    Journal Theranostics
    Authors Jiangli Zhao, et al.
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  • Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression
    Year 2026
    Journal Front Immunol
    Authors Wenxin Da, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression
    Year 2026
    Journal Life Sci
    Authors Mingxing Sui, et al.
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  • Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression
    Year 2026
    Journal Cell Death Dis
    Authors Yang Shizhou, et al.
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  • Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion
    Year 2026
    Journal Theranostics
    Authors Yi-Fan Zhou, et al.
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  • Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation
    Year 2026
    Journal Inflammation
    Authors Wang Ziqian, et al.
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  • PDP1 drives hepatocellular carcinoma progression by regulating senescence through the cAMP/Ca2+ signaling pathway
    Year 2026
    Journal Biochem Pharmacol
    Authors Jiamin Xie, et al.
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  • Dietary Selenium deficiency activates the NLRP3 inflammasome to induce gallbladder pyroptosis by regulating glycolysis and histone lactylation through ROS/HIF-1α pathway
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    Journal J Nutr Biochem
    Authors Zhaoyang An, et al.
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  • Bisphenol A Promotes Ovarian Cancer Proliferation and Migration through the HK2/H3K18la/IGF2BP3 Sequential Regulatory Axis
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    Journal J Agric Food Chem
    Authors Xin Xie, et al.
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  • A novel integrative machine learning-based prognostic model reveals lactylation regulation in hepatocellular carcinoma progression
    Year 2026
    Journal Cancer Cell
    Authors Yihang Song, et al.
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  • PRC1 promotes MAFLD progression by regulating glycolysis/lactylation axis and forming a positive feedback loop
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    Journal J Nutr Biochem
    Authors Xinlei Zou, et al.
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  • CircBARD1 suppresses tumor progression driven by H3K18 lactylationCCNA2 axis in human bladder cancer
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    Journal Cell Oncol (Dordr)
    Authors Zhenghui Hu, et al.
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  • HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription
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    Authors Xiaoxuan Zhao, et al.
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    Authors Chuyang Tai
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  • Lactylation-induced TRIM47 exacerbates cell viability, cell cycle progression, and glycolysis in thyroid cancer by inducing ubiquitin-mediated degradation of FBP1
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    Authors Faren Zhang, et al.
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  • A metabolic reprogramming and trained immunity hydrogel mimic cluster missiles to eliminate infection and treat infected diabetic wounds
    Year 2025
    Journal J Nanobiotechnology
    Authors Yu Zirui, et al.
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  • Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neurons
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    Journal Sci Signal
    Authors Yu-Tao Deng, et al.
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  • Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
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    Journal Signal Transduct Target Ther
    Authors She Han, et al.
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  • ChIP-seq and RNA-seq Reveal the Involvement of Histone Lactylation Modification in Early Pregnancy with Subclinical Hypothyroidism
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    Authors Cheng Chaofei, et al.
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    Applications Unspecified
    Reactivity
  • H3K18 lactylation drives the progression of silica nanoparticles-induced pulmonary fibrosis via promoting macrophage M1 polarization
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    Journal J Hazard Mater
    Authors Lili Shi, et al.
    Applications Unspecified
    Reactivity
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    Journal Exp Cell Res
    Authors Ye Linlin, et al.
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    Reactivity
  • H3K18 lactylation potentiates microglial polarization via the TLR4 pathway in diabetes-induced cognitive impairment
    Year 2025
    Journal JCI Insight
    Authors Ying Yang, et al.
    Applications Unspecified
    Reactivity
  • H3K18 lactylation-hexokinase 2 positive feedback loop promotes osteogenesis of ASPCs in facial infiltrating lipomatosis
    Year 2025
    Journal Stem Cell Res Ther
    Authors Chen Hongrui, et al.
    Applications WB, IF, CUT&Tag
    Reactivity
  • H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition (EMT) of airway epithelial cells
    Year 2025
    Journal Toxicology
    Authors Songtao Liu, et al.
    Applications Unspecified
    Reactivity
  • H3K9/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells
    Year 2025
    Journal Toxicol Appl Pharmacol
    Authors Xiaomin Xie, et al.
    Applications Unspecified
    Reactivity
  • H4K12 lactylation potentiates mitochondrial oxidative stress via the Foxo1 pathway in diabetes-induced cognitive impairment
    Year 2025
    Journal J Adv Res
    Authors Ying Yang, et al.
    Applications WB
    Reactivity
  • Helicobacter pylori infection aggravates hepatic steatosis by lactylation-driven WTAP-mediated m6A modification
    Year 2025
    Journal Gut Microbes
    Authors Han Chen, et al.
    Applications ICC/IF
    Reactivity
  • Histone H3 lysine 18 lactylation promotes alveolar epithelial cell apoptosis in sepsis-induced lung injury by upregulating caspase-8 in vivo and in vitro
    Year 2025
    Journal Exp Cell Res
    Authors Ping Lin, et al.
    Applications Unspecified
    Reactivity
  • Histone H3K18 lactylation-dependent epigenetic activation of RUNX2 orchestrates PI3K/AKT oncogenic signaling in laryngeal squamous cell carcinoma
    Year 2025
    Journal J Mol Histol
    Authors Fu Daidi, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation contributes to neuropathic pain by facilitating m6A reader protein IGF2BP2 expression in DRG sensory neurons
    Year 2025
    Journal J Neurosci
    Authors Qi-Hui Wang, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation
    Year 2025
    Journal Redox Biol
    Authors Jiayan Huang, et al.
    Applications ChIP-Seq
    Reactivity
  • Histone lactylation is associated with METTL3-dependent LCN2 m6A modification and astrocyte activation after intracerebral hemorrhage
    Year 2025
    Journal Neurochem Int
    Authors Ling Gao, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation regulates early embryonic development through m6A methyltransferase METTL3 in goats
    Year 2025
    Journal Int J Biol Macromol
    Authors Dongxu Li, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury
    Year 2025
    Journal Autophagy
    Authors Lei Xu, et al.
    Applications Unspecified
    Reactivity
  • Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells
    Year 2025
    Journal Adv Sci (Weinh)
    Authors Jinna Li, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation-induced GLI3 activation drives macrophage M1 polarization and exosomal SERPINE1 release in abdominal aortic aneurysm progression
    Year 2025
    Journal Cell Death Discov
    Authors Yuan Kai, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation-induced premature senescence contributes to 1-nitropyrene-Induced chronic obstructive pulmonary disease
    Year 2025
    Journal Redox Biol
    Authors Rong-Rong Wang, et al.
    Applications Unspecified
    Reactivity
  • IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy
    Year 2025
    Journal Cell Mol Life Sci
    Authors Hu Xiaofang, et al.
    Applications ChIP-qPCR
    Reactivity
  • Lactate metabolism inhibition disrupts goat oocyte meiosis via H3K18la-mediated epigenetic dysregulation
    Year 2025
    Journal Theriogenology
    Authors Dongxu Li, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes collagen expression, proliferation and migration through H3K18 lactylation-dependent stimulation of LTBP3/TGF-β1 axis in keloid fibroblasts
    Year 2025
    Journal J Invest Dermatol
    Authors Jing-Jing Gu, et al.
    Applications Unspecified
    Reactivity
  • Lactate-mediated histone lactylation promotes melanoma angiogenesis via IL-33/ST2 axis
    Year 2025
    Journal Cell Death Dis
    Authors Zhao Mao, et al.
    Applications ChIP
    Reactivity
  • Lactylation-induced ALKBH5 targets RNF123 to worsen retinal Müller cell activation through PKM2-regulated Glycolysis in diabetic retinopathy
    Year 2025
    Journal J Transl Med
    Authors Luo Shasha, et al.
    Applications ChIP
    Reactivity
  • Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation-Mediated FGFR4 Activation
    Year 2025
    Journal Adv Sci (Weinh)
    Authors Zehua Ye, et al.
    Applications Unspecified
    Reactivity
  • Lipopolysaccharide-induced histone lactylation mediates m6A RNA modification causing mitochondrial dysfunction and pulmonary fibroblasts activation to exacerbate sepsis-associated pulmonary fibrosis
    Year 2025
    Journal Respir Res
    Authors Tang Ri, et al.
    Applications Unspecified
    Reactivity
  • lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation
    Year 2025
    Journal Mol Med Rep
    Authors Li Yu, et al.
    Applications ChIP-qPCR
    Reactivity
  • Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory
    Year 2025
    Journal Cell
    Authors Athanasios Ziogas, et al.
    Applications Unspecified
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  • Mesenchymal Stem Cell-Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation
    Year 2025
    Journal Adv Sci (Weinh)
    Authors Qiang Huang, et al.
    Applications Unspecified
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  • METTL3 regulated by histone lactylation promotes ossification of the ligamentum flavum by enhancing the m6A methylation of BMP2
    Year 2025
    Journal Mol Med
    Authors Jiaming Zhou, et al.
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  • Mitophagy Reprograms Lactate Metabolism to Suppress THBS1 via H3K18la Reduction, Alleviating Intervertebral Disc Degeneration
    Year 2025
    Journal Research (Wash D C)
    Authors Kanbin Wang, et al.
    Applications Unspecified
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  • Neddylation inhibitor MLN4924 enhances H3K18 lactylation via binding to LDH and downregulates ITGB4 to block metastasis
    Year 2025
    Journal J Biol Chem
    Authors Hongfei Yu, et al.
    Applications Unspecified
    Reactivity
  • Organoid modeling identifies USP3-AS1 as a novel promoter in colorectal cancer liver metastasis through increasing glucose-driven histone lactylation
    Year 2025
    Journal Acta Pharmacol Sin
    Authors Zhou Jia-min, et al.
    Applications Unspecified
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  • Protocatechuic aldehyde promotes diabetic wound healing by enhancing angiogenesis via H3K18 lactylation-mediated Acvr1c expression
    Year 2025
    Journal Mol Immunol
    Authors Weijing Fan, et al.
    Applications Unspecified
    Reactivity
  • Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells
    Year 2025
    Journal ACS Chem Biol
    Authors Xinlong Guo, et al.
    Applications Unspecified
    Reactivity
  • SPRY1 Interaction with CBL Promotes Vimentin Stabilization to Enhance Malignant Progression and Metastasis in Wilms Tumor
    Year 2025
    Journal Ann Surg Oncol
    Authors Huang Fan, et al.
    Applications Unspecified
    Reactivity
  • Structural characterization and anti-hepatic fibrosis effects of a novel polysaccharide from Astragalus complanatus seeds
    Year 2025
    Journal Carbohydr Polym
    Authors Zhi-Fan Zhu, et al.
    Applications Unspecified
    Reactivity
  • The effect of lactate dehydrogenase B and its mediated histone lactylation on chondrocyte ferroptosis during osteoarthritis
    Year 2025
    Journal J Orthop Surg Res
    Authors Zhang Yang, et al.
    Applications WB
    Reactivity
  • The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance
    Year 2025
    Journal J Gastrointest Oncol
    Authors Kunli Zhu, et al.
    Applications Unspecified
    Reactivity
  • TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation
    Year 2025
    Journal Aging Cell
    Authors Yue Wang, et al.
    Applications WB, IHC-P, IF, CUT&Tag
    Reactivity
  • WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma
    Year 2025
    Journal Adv Sci (Weinh)
    Authors Tao Huang, et al.
    Applications WB
    Reactivity
  • Histone lactylation exacerbates acute lung injury in septic mice by promoting fer roptosis in pulmonary microvascular endothelial cells
    Year 2025
    Journal Burns Trauma
    Authors Pu Fang, et al.
    Applications WB, CUT&Tag
    Reactivity
  • A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
    Year 2024
    Journal Genome Biol
    Authors Fan Wei, et al.
    Applications WB
    Reactivity
  • DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation
    Year 2024
    Journal J Mol Cell Biol
    Authors Yang Yaqi, et al.
    Applications Unspecified
    Reactivity
  • H3K18 lactylation accelerates liver fibrosis progression through facilitating SOX9 transcription
    Year 2024
    Journal Exp Cell Res
    Authors Shujun Wu, et al.
    Applications Unspecified
    Reactivity
  • Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury
    Year 2024
    Journal Adv Sci (Weinh)
    Authors Jiao Qiao, et al.
    Applications Unspecified
    Reactivity
  • Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis
    Year 2024
    Journal Phytomedicine
    Authors Tianya Xiang, et al.
    Applications Unspecified
    Reactivity
  • Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation
    Year 2024
    Journal Cell Mol Life Sci
    Authors Zhao Yanhua, et al.
    Applications Unspecified
    Reactivity
  • Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury
    Year 2024
    Journal Adv Sci (Weinh)
    Authors Zongqing Lu, et al.
    Applications Unspecified
    Reactivity
  • Low level exposure to BDE-47 facilitates the development of prostate cancer through TOP2A/LDHA/lactylation positive feedback circuit
    Year 2024
    Journal Environ Res
    Authors Linlin Tian, et al.
    Applications Unspecified
    Reactivity
  • Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation
    Year 2024
    Journal Cell Rep
    Authors Yunjia Zhang, et al.
    Applications Unspecified
    Reactivity
  • Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
    Year 2024
    Journal Cell Metab
    Authors Ruilong Liu, et al.
    Applications Unspecified
    Reactivity
  • The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation
    Year 2024
    Journal BMC Urol
    Authors Wang Rong, et al.
    Applications Unspecified
    Reactivity
  • Virus-Induced Histone Lactylation Promotes Virus Infection in Crustacean
    Year 2024
    Journal Adv Sci (Weinh)
    Authors Yu Zhang, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation promotes cell proliferation, migration and invasion through targeting HMGB1 in endometriosis
    Year 2023
    Journal J Biomed Res
    Authors Jie Chen, et al.
    Applications ChIP-qPCR
    Reactivity
  • CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer
    Year 2023
    Journal Mol Cancer
    Authors Xie Bo, et al.
    Applications CUT&Tag
    Reactivity
  • Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
    Year 2023
    Journal Cell Metab
    Authors Hyunsoo Rho, et al.
    Applications Unspecified
    Reactivity
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