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Recombinant Rabbit Monoclonal
Anti-L-Lactyl-Histone H3 (Lys18) Rabbit mAb
Catalog Number: PTM-1406RM
References (116)
$ 420

Clone Number: 22H2L3

Host: Rabbit Clonality: Recombinant Monoclonal

Applications： WB IHC-P ICC/IF IP

Reactivity: Human, Mouse, Rat

Synonyms: H3K18la

Product Size
100 μl
Quantity

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms H3K18la
UniProt ID

P68431

Immunogen L-lactylated human histone H3 (Lys18) peptide
MW (kDa) 15
Specificity Anti-L-Lactyl-Histone H3 (Lys18) Rabbit mAb detects histone H3 only when it is lactylated at Lys18.
Product Usage Information
Applications Dilution Recommended Species
WB 1:500 - 1:2000 Human, Mouse, Rat
IHC-P 1:200 - 1:1000 Human
ICC/IF 1:50 - 1:100 Human
IP 1:50 Human
Properties
Purity Protein A purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

Histones, fundamental proteins involved in chromatin structure and gene regulation, are subject to a wide array of enzyme-catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, and numerous others. Histone L-lactylation, a recently discovered post-translational modification induced by lactate has emerged as a significant addition to this repertoire. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The introduction of lysine L-lactylation is mediated by the acetyltransferase p300, while the removal of lactylation marks from histones has been attributed to Class I histone deacetylases (HDAC 1-3). Histone lactylation has been implicated in various biological processes, including inflammation, fibrosis, differentiation, and cancer progression.

Cellular location

Nucleus

Images
Dot Blot

Peptide amount: 1 ng, 4 ng, 16 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
The list of peptides used in the experiment is provided below.
Lane 1: H3K18 L-lactyl. Lane 2: H3K14 crotonyl.
Lane 3: H3K14 benzoyl. Lane 4: H3K14 L-lactyl.
Lane 5: H3K18 butyryl. Lane 6: H3K18 crotonyl.
Lane 7: H3K18 2-hydroxyisobutyryl. Lane 8: H3K18 benzoyl.
Lane 9: H3K23 crotonyl. Lane 10: H3K23 benzoyl.
Lane 11: H3K23 L-lactyl. Lane 12: H3K27 crotonyl.
Lane 13: H3K27 L-lactyl. Lane 14: H3K18 unmodified.
WB

Lysates: (-) HeLa cells; (+) HeLa cells treated with 100 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa

Lysates: C2C12, RAW264.7, EL4.IL-2
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa

Lysates: PC-12, Rat spleen, Rat brain
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa
IHC-P

Tissue: Human breast cancer
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-1406RM.
ICC/IF

Samples: (A) HeLa cells; (B) HeLa cells treated with 100 mM sodium lactate for 24 hours
Fixative: 4% Paraformaldehyde
Permeabilization: 0.1% Triton X-100
Primary Ab dilution: 1:100
Primary Ab incubation: 4°C overnight
Secondary Ab: Goat Anti-Rabbit IgG
Nuclear counter stain: DAPI (blue)
Counter stain: Tubulin (red)
Description: The green color represents the positive signal observed with PTM-1406RM.
IP

IP of HeLa+ sodium lactate (100 mM, 24 hours) extracts
Lane 1: 5% Input
Lane 2: IP with PTM-1406RM
Lane 3: IP with Rabbit mAb IgG Isotype Control
IP Ab incubation: 4°C overnight, 1:50 dilution
Blocking buffer: 5% NFDM/TBST
Dilution buffer: 5% NFDM/TBST
WB Primary Ab incubation: PTM-1406RM, 1:1000 dilution, 2 hours at room temperature
Secondary Ab: Anti-Rabbit IgG for IP (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa

Research Use

For research use only, not for use in diagnostic procedures.

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References (116)
  • m5C-Modified tRF3b-CysGCA-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4
    Year 2026
    Journal Advanced Science
    Authors Xiaoling Ying, et al.
    Applications Unspecified
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  • Single-Atom Nanozyme Driven Lactate Reversal Fuels Oxidative Metabolism and Represses Lactylation to Heal Diabetic Wounds
    Year 2026
    Journal ACS Nano
    Authors Wei Wu, et al.
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  • Histone H3K9 Lactylation Activates the TXNIP/NLRP3 Pathway to Drive Macrophage Inflammation after Spinal Cord Injury
    Year 2026
    Journal Redox Biology
    Authors Chaoran Shi, et al.
    Applications Unspecified
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  • Targeting the SIN1 mediated TTK/LDHA-H3K18la-GLUT3 axis disrupts metabolic-epigenetic crosstalk and suppresses progression in hyperglycolytic breast cancer
    Year 2026
    Journal CANCER LETTERS
    Authors Zewei Zhao, et al.
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  • Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma
    Year 2026
    Journal Frontiers in Veterinary Science
    Authors Tamami Suzuki, et al.
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  • STING controls glycolysis and histone lactylation to drive macrophage metabolic reprogramming in postoperative ileus
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    Journal Communications Biology
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  • Asprosin-driven metabolic-epigenetic rewiring attenuates mesenchymal stem cell senescence with therapeutic benefits for infarcted hearts
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    Journal Journal of Advanced Research
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  • AOC3 Loss Promotes Imatinib Resistance in GIST by Stabilizing HK2 and Enhancing H3K18la-Driven Myc Transcription
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    Journal MOLECULAR CARCINOGENESIS
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  • Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation
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  • Lactate regulates the YTHDF2-FTH1 axis to promote cardiomyocyte ferroptosis and aggravate myocardial ischemia-reperfusion injury
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    Journal VASCULAR PHARMACOLOGY
    Authors Chuyan Long, et al.
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  • NEAT1 is a therapeutic target for reversing T-cell exhaustion in bladder cancer
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    Applications Unspecified
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    Applications Unspecified
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    Authors Ling Gao, et al.
    Applications Unspecified
    Reactivity
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    Authors Zhao Mao, et al.
    Applications Unspecified
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    Year 2025
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    Authors Weijing Fan, et al.
    Applications Unspecified
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    Year 2025
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    Authors Zheng Jianxiong, et al.
    Applications Unspecified
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    Year 2025
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    Reactivity
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    Year 2025
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    Authors Shan Hu, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes collagen expression, proliferation and migration through H3K18 lactylation-dependent stimulation of LTBP3/TGF-β1 axis in keloid fibroblasts
    Year 2025
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    Authors Jing-Jing Gu, et al.
    Applications Unspecified
    Reactivity
  • Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage
    Year 2025
    Journal Advanced Science
    Authors Jiaxi Zhang, et al.
    Applications Unspecified
    Reactivity
  • NDRG1-Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment
    Year 2025
    Journal Advanced Science
    Authors Gujie Wu, et al.
    Applications Unspecified
    Reactivity
  • Luteolin attenuates RA-associated chronic pain by targeting the LDHA/H3K9la/NFATC2 axis to suppress Th17 cell differentiation and central infiltration
    Year 2025
    Journal Journal of Pharmaceutical Analysis
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    Applications Unspecified
    Reactivity
  • Gastrodin regulates H3K14la through the CDT2-KAT2A axis to treat Sepsis-induced myocardial dysfunction
    Year 2025
    Journal INTERNATIONAL IMMUNOPHARMACOLOGY
    Authors Huiming Yu, et al.
    Applications Unspecified
    Reactivity
  • Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation
    Year 2025
    Journal ACTA PHARMACOLOGICA SINICA
    Authors Wang Zhen-chuan, et al.
    Applications Unspecified
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  • Lactate regulates cell differentiation of erythroid progenitor cells via histone lactylation modification
    Year 2025
    Journal iScience
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    Applications Unspecified
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  • tsRNA-08614 inhibits glycolysis and histone lactylation by ALDH1A3 to confer oxaliplatin sensitivity in colorectal cancer
    Year 2025
    Journal Translational Oncology
    Authors Zhengbo Chen, et al.
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  • IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy
    Year 2025
    Journal CELLULAR AND MOLECULAR LIFE SCIENCES
    Authors Hu Xiaofang, et al.
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  • H3K18 lactylation-mediated Ythdf2 activation restrains mouse female germline stem cell proliferation via promoting Ets1 mRNA degradation
    Year 2025
    Journal Clinical Epigenetics
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  • Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury
    Year 2025
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    Authors Xuhui Ge, et al.
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  • Cisplatin reduces immunosuppression caused by tumor-associated macrophages through downregulating CD47-SIRPα signaling in glioblastoma
    Year 2025
    Journal BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
    Authors Yanyan Li, et al.
    Applications Unspecified
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  • The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance
    Year 2025
    Journal Journal of Gastrointestinal Oncology
    Authors Kunli Zhu, et al.
    Applications Unspecified
    Reactivity
  • Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate
    Year 2025
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    Authors Pengfei Li, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation facilitates MCM7 expression to maintain stemness and radio-resistance in hepatocellular carcinoma
    Year 2025
    Journal BIOCHEMICAL PHARMACOLOGY
    Authors Zijian Liu, et al.
    Applications Unspecified
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  • H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes
    Year 2025
    Journal Journal of Neuroinflammation
    Authors Li Jing, et al.
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  • Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury
    Year 2025
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  • Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis
    Year 2025
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    Year 2025
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  • Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation
    Year 2025
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    Authors Jiayan Huang, et al.
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  • Revealing the effects of lactate on bovine SCNT embryo development through transcriptome sequencing analyses
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  • Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis
    Year 2025
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    Authors Xu Ying, et al.
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    Authors Zehua Ye, et al.
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    Year 2025
    Journal JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
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  • Lactate promotes premature aging of preeclampsia placentas through histone lactylation-regulated GADD45A
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    Year 2025
    Journal CLINICAL SCIENCE
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    Year 2025
    Journal DEVELOPMENTAL CELL
    Authors Zhimin Li, et al.
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    Year 2024
    Journal Journal for ImmunoTherapy of Cancer
    Authors Qianqian Xue, et al.
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    Year 2024
    Journal CANCER LETTERS
    Authors Wenfei Du, et al.
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    Year 2024
    Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
    Authors Zhou Jin, et al.
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    Year 2024
    Journal DNA AND CELL BIOLOGY
    Authors Chenlingzi Huang, et al.
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  • Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
    Year 2024
    Journal Cell Metabolism
    Authors Ruilong Liu, et al.
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  • Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
    Year 2024
    Journal Acta Pharmaceutica Sinica B
    Authors Han Liu, et al.
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    Year 2024
    Journal Nature Communications
    Authors Chen Zhuo, et al.
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  • GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation
    Year 2024
    Journal Journal of Translational Medicine
    Authors Liu Chenyang, et al.
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  • Pre-implantation embryo metabolism identified by PEMA reveals endogenous lactate insufficiency contributes to pre-implantation development arrest
    Year 2024
    Journal Fundamental Research
    Authors Jingyu Li, et al.
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  • Lactylation drives hCG-triggered luteinization in hypoxic granulosa cells
    Year 2024
    Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
    Authors Gang Wu, et al.
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    Year 2024
    Journal iScience
    Authors Runhua Du, et al.
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    Year 2024
    Journal Cell Reports
    Authors Ruijie Wang, et al.
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    Year 2024
    Journal AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
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    Year 2024
    Journal Journal of Neuroinflammation
    Authors Hu Xuyang, et al.
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    Year 2024
    Journal TISSUE & CELL
    Authors Zhen-Peng Xu, et al.
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    Year 2024
    Journal Redox Biology
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    Year 2024
    Journal Journal of Animal Science and Biotechnology
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    Year 2024
    Journal JOURNAL OF PROTEOME RESEARCH
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    Year 2024
    Journal Advanced Science
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    Journal Cell Reports
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    Journal REPRODUCTION
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    Year 2024
    Journal BASIC RESEARCH IN CARDIOLOGY
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    Year 2024
    Journal Molecular Metabolism
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    Journal DRUG RESISTANCE UPDATES
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    Journal Cell Metabolism
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    Year 2024
    Journal Nature Communications
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    Year 2024
    Journal MOLECULES
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    Year 2023
    Journal Cell Metabolism
    Authors Hyunsoo Rho, et al.
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    Journal Cell Metabolism
    Authors Xuedan Sun, et al.
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    Journal DEVELOPMENTAL CELL
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    Journal JOURNAL OF VIROLOGY
    Authors Yu Pang, et al.
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    Journal Immunity & Ageing
    Authors Han Hao, et al.
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    Journal ENDOCRINOLOGY
    Authors Zhao Wei, et al.
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    Journal EMBO REPORTS
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    Authors Morgan Towriss, et al.
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    Year 2023
    Journal Journal of Neuroinflammation
    Authors Wei Lin, et al.
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    Journal Molecular Cancer
    Authors Xie Bo, et al.
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    Year 2023
    Journal EUROPEAN JOURNAL OF PHARMACOLOGY
    Authors Ying Yu, et al.
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    Year 2023
    Journal CLINICAL CANCER RESEARCH
    Authors Chaudagar Kiranj, et al.
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    Year 2022
    Journal Cell Metabolism
    Authors Rui-Yuan Pan, et al.
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    Year 2022
    Journal MOLECULAR CELL
    Authors Jia Xiong, et al.
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    Year 2022
    Journal Journal of Molecular Cell Biology
    Authors Chen Jian, et al.
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    Year 2022
    Journal OncoImmunology
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    Year 2022
    Journal Cells
    Authors Qing Tian, et al.
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    Year 2022
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    Year 2022
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    Authors Lucia Longhitano, et al.
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    Year 2022
    Journal GENOME BIOLOGY
    Authors Galle Eva, et al.
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    Year 2021
    Journal JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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    Year 2021
    Journal Epigenetics & Chromatin
    Authors Yang Wanting, et al.
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