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Recombinant Rabbit Monoclonal
Anti-L-Lactyl-Histone H3 (Lys9) Rabbit mAb
Catalog Number: PTM-1419RM
References (58)
$ 435

Clone Number: 13H2L1

Host: Rabbit Clonality: Recombinant Monoclonal

Applications： WB IHC-P ChIP

Reactivity: Human, Mouse, Rat

Synonyms: H3K9la

Product Size
100 μl
Quantity

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms H3K9la
UniProt ID

P68431

Immunogen L-lactylated human histone H3 (Lys9) peptide
MW (kDa) 15
Specificity Anti-L-Lactyl-Histone H3 (Lys9) Rabbit mAb detects histone H3 only when it is L-lactylated at Lys9.
Product Usage Information
Applications Dilution Recommended Species
WB 1:500 - 1:2000 Human, Mouse, Rat
IHC-P 1:200 - 1:1000 Human
ChIP 6 μg per 5x106 cells Human
Properties
Purity Protein A purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

Histones, fundamental proteins involved in chromatin structure and gene regulation, are subject to a wide array of enzyme-catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, and numerous others. Histone L-lactylation, a recently discovered post-translational modification induced by lactate has emerged as a significant addition to this repertoire. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The introduction of lysine L-lactylation is mediated by the acetyltransferase p300, while the removal of lactylation marks from histones has been attributed to Class I histone deacetylases (HDAC 1-3). H3K9 lactylation (H3K9la) has been implicated in tumorigenesis, particularly in hepatocellular carcinoma (HCC), where it plays a role in disease progression. Aberrant levels of H3K9la have been observed in HCC and positively correlate with the expression of markers of cancer malignancy, such as CD133, BCL2, Ki67, and LDHA.

Cellular location

Nucleus

Images
Dot Blot

Peptide amount: 1 ng, 4 ng, 16 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:10000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
The list of peptides used in the experiment is provided below.
Lane 1: H3K9 L-lactyl. Lane 2: H3K9 crotonyl.
Lane 3: H3K9 2-hydroxyisobutyryl. Lane 4: H3K27 crotonyl.
Lane 5: H3K27 2-hydroxyisobutyryl. Lane 6: H3K27 L-lactyl.
Lane 7: H3K9 unmodified.
WB

Lysates: (-) HeLa cells; (+) HeLa cells treated with 100 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: 15 kDa
Observed band size: 15 kDa
IHC-P

Tissue: Human colon cancer
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-1419RM.

Tissue: Human lung squamous carcinoma
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-1419RM.
ChIP

Sample: HeLa cells treated with 100 mM sodium lactate for 24 hours
Cross-linking conditions: no cross-linking
Amount of chromatin per IP: 5x106 cells
Amount of Ab per IP: 6 μg
Beads type and amount per IP: 50 μL of Protein A MagBeads
Description: Chromatin immunoprecipitations were performed with 6 μg of normal rabbit IgG as a negative control. The immunoprecipitated DNA was quantified by real-time PCR using primers specific for the human GAPDH-CDS, RPL30, and LDHA regions. The data are presented as enrichment of each sample relative to the total amount of input at each amplicon.

Research Use

For research use only, not for use in diagnostic procedures.

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References (58)
  • m5C-Modified tRF3b-CysGCA-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4
    Year 2026
    Journal Advanced Science
    Authors Xiaoling Ying, et al.
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  • Single-Atom Nanozyme Driven Lactate Reversal Fuels Oxidative Metabolism and Represses Lactylation to Heal Diabetic Wounds
    Year 2026
    Journal ACS Nano
    Authors Wei Wu, et al.
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  • Saikosaponin D Inhibits Gastric Cancer Progression by targeting PKM2-Mediated Glycolysis and Histone Lactylation
    Year 2026
    Journal PHYTOMEDICINE
    Authors Weijia Wang, et al.
    Applications Unspecified
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  • Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway
    Year 2026
    Journal Cell Death & Disease
    Authors Hua Ruheng, et al.
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    Reactivity
  • STING controls glycolysis and histone lactylation to drive macrophage metabolic reprogramming in postoperative ileus
    Year 2026
    Journal Communications Biology
    Authors Kai Chen, et al.
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  • Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion
    Year 2026
    Journal Theranostics
    Authors Jiangli Zhao, et al.
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  • Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression
    Year 2026
    Journal LIFE SCIENCES
    Authors Mingxing Sui, et al.
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  • Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation
    Year 2026
    Journal INFLAMMATION
    Authors Wang Ziqian, et al.
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  • Jaceosidin Attenuates Sepsis-Induced Myocardial Dysfunction by Promoting SIRT2-Mediated Inhibition of Histone H3K18 Lactylation
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    Journal Pharmaceuticals
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  • Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance
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  • H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2+ Treg recruitment
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    Journal EXPERIMENTAL AND MOLECULAR MEDICINE
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  • Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk
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  • Histone H3K18 lactylation-dependent epigenetic activation of RUNX2 orchestrates PI3K/AKT oncogenic signaling in laryngeal squamous cell carcinoma
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    Journal JOURNAL OF MOLECULAR HISTOLOGY
    Authors Fu Daidi, et al.
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  • Histone Lactylation-Mediated PAD4 Up-Regulation Promotes Septic Acute Kidney Injury via Activating NETosis
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    Journal NEPHROLOGY
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  • Sirtuin 6 is a histone delactylase
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    Authors Yue Wang, et al.
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  • H3K18 lactylation-hexokinase 2 positive feedback loop promotes osteogenesis of ASPCs in facial infiltrating lipomatosis
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    Journal Stem Cell Research & Therapy
    Authors Chen Hongrui, et al.
    Applications Unspecified
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  • Protocatechuic aldehyde promotes diabetic wound healing by enhancing angiogenesis via H3K18 lactylation-mediated Acvr1c expression
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    Journal MOLECULAR IMMUNOLOGY
    Authors Weijing Fan, et al.
    Applications Unspecified
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  • Royal jelly acid inhibits NF-κB signaling by regulating H3 histone lactylation to alleviate IgE-mediated mast cell activation and allergic inflammation
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    Journal PHYTOMEDICINE
    Authors Xue-Ting Xu, et al.
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  • Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions
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    Journal Stem Cell Research & Therapy
    Authors Wenhong Xu, et al.
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  • Chronic intermittent hypoxia impairs BM-MSC osteogenesis and long bone growth through regulating histone lactylation
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    Journal Journal of Translational Medicine
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    Journal Frontiers in Pharmacology
    Authors Yufang Dai, et al.
    Applications Unspecified
    Reactivity
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    Authors Lei Xu, et al.
    Applications Unspecified
    Reactivity
  • Metabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop
    Year 2025
    Journal CELL DEATH AND DIFFERENTIATION
    Authors Xiong Junjun, et al.
    Applications Unspecified
    Reactivity
  • Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation-Mediated FGFR4 Activation
    Year 2025
    Journal Advanced Science
    Authors Zehua Ye, et al.
    Applications Unspecified
    Reactivity
  • A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1
    Year 2025
    Journal CLINICAL SCIENCE
    Authors Zhu Yi, et al.
    Applications Unspecified
    Reactivity
  • Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice
    Year 2025
    Journal DEVELOPMENTAL CELL
    Authors Zhimin Li, et al.
    Applications Unspecified
    Reactivity
  • Development of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells
    Year 2025
    Journal Nature Communications
    Authors Wang Yu, et al.
    Applications Unspecified
    Reactivity
  • Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson’s disease via histone lactylation
    Year 2025
    Journal npj Parkinsons Disease
    Authors Qin Qixiong, et al.
    Applications Unspecified
    Reactivity
  • Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways
    Year 2025
    Journal Advanced Science
    Authors Fanju Meng, et al.
    Applications Unspecified
    Reactivity
  • DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation
    Year 2024
    Journal Journal of Molecular Cell Biology
    Authors Yang Yaqi, et al.
    Applications Unspecified
    Reactivity
  • Tanshinone I reprograms glycolysis metabolism to regulate histone H3 lysine 18 lactylation (H3K18la) and inhibits cancer cell growth in ovarian cancer
    Year 2024
    Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
    Authors Zhou Jin, et al.
    Applications Unspecified
    Reactivity
  • Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
    Year 2024
    Journal Acta Pharmaceutica Sinica B
    Authors Han Liu, et al.
    Applications Unspecified
    Reactivity
  • Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway
    Year 2024
    Journal Biomedicines
    Authors Lu He, et al.
    Applications Unspecified
    Reactivity
  • H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
    Year 2024
    Journal Cell Reports
    Authors Ruijie Wang, et al.
    Applications Unspecified
    Reactivity
  • Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage
    Year 2024
    Journal Journal of Neuroinflammation
    Authors Zhang Fan, et al.
    Applications Unspecified
    Reactivity
  • A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
    Year 2024
    Journal GENOME BIOLOGY
    Authors Fan Wei, et al.
    Applications Unspecified
    Reactivity
  • Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la/KLF5 pathway
    Year 2024
    Journal Redox Biology
    Authors Xuanxuan Zhang, et al.
    Applications Unspecified
    Reactivity
  • The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation
    Year 2024
    Journal Journal of Animal Science and Biotechnology
    Authors Wei Yaozong, et al.
    Applications Unspecified
    Reactivity
  • Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury
    Year 2024
    Journal Advanced Science
    Authors Jiao Qiao, et al.
    Applications Unspecified
    Reactivity
  • Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation
    Year 2024
    Journal Cell Reports
    Authors Yunjia Zhang, et al.
    Applications Unspecified
    Reactivity
  • Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and Histone lactylation
    Year 2024
    Journal REPRODUCTION
    Authors Xiaoyang Wen, et al.
    Applications Unspecified
    Reactivity
  • Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification
    Year 2024
    Journal BRITISH JOURNAL OF PHARMACOLOGY
    Authors Chunli Wang, et al.
    Applications Unspecified
    Reactivity
  • Augmentation of scleral glycolysis promotes myopia through histone lactylation
    Year 2024
    Journal Cell Metabolism
    Authors Xiaolei Lin, et al.
    Applications Unspecified
    Reactivity
  • Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
    Year 2023
    Journal Cell Metabolism
    Authors Hyunsoo Rho, et al.
    Applications Unspecified
    Reactivity
  • Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites
    Year 2023
    Journal PHYTOMEDICINE
    Authors Haiying Xu, et al.
    Applications Unspecified
    Reactivity
  • Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota.
    Year 2021
    Journal Frontiers in Immunology
    Authors Sun S, et al.
    Applications Unspecified
    Reactivity
  • Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains
    Year 2021
    Journal JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
    Authors Xiaoxi Meng, et al.
    Applications Unspecified
    Reactivity
  • Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota
    Year 2021
    Journal Frontiers in Immunology
    Authors Sun Siyuan, et al.
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