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Recombinant Rabbit Monoclonal
Anti-L-Lactyl-Histone H4 (Lys12) Rabbit mAb
Catalog Number: PTM-1411RM
References (59)
$ 435

Clone Number: 37H4L1

Host: Rabbit Clonality: Recombinant Monoclonal

Applications： WB IHC-P IP ChIP

Reactivity: Human, Mouse, Rat

Synonyms: H4K12la

Product Size
100 μl
Quantity

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms H4K12la
UniProt ID

P62805

Immunogen L-lactylated human histone H4 (Lys12) peptide
MW (kDa) 11
Specificity Anti-L-Lactyl-Histone H4 (Lys12) Rabbit mAb detects histone H4 when it is L-lactylated at Lys12.
Product Usage Information
Applications Dilution Recommended Species
WB 1:500 - 1:2000 Human, Mouse, Rat
IHC-P 1:200 - 1:1000 Human, Mouse, Rat
IP 1:50 - 1:100 Human
ChIP 6 μg per 5x106 cells Human
Properties
Purity Protein A purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

Histones, fundamental proteins involved in chromatin structure and gene regulation, are subject to a wide array of enzyme-catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, and numerous others. Histone L-lactylation, a recently discovered post-translational modification induced by lactate has emerged as a significant addition to this repertoire. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The introduction of lysine L-lactylation is mediated by the acetyltransferase p300, while the removal of lactylation marks from histones has been attributed to Class I histone deacetylases (HDAC 1-3). Histone lactylation has been implicated in various biological processes, including inflammation, fibrosis, differentiation, and cancer progression.

Cellular location

Nucleus

Images
Dot Blot

Peptide amount: 1ng, 4 ng, 16 ng, 64 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 10 seconds
The list of peptides used in the experiment is provided below.
Lane 1: H4K12 L-lactyl. Lane 2: H4K12 crotonyl.
Dot 3: H4K5 crotonyl. Dot 4: H4K5 2-hydroxyisobutyryl.
Dot 5: H4K5 L-lactyl. Dot 6: H4K8 crotonyl.
Dot 7: H4K8 L-lactyl. Dot 8: H4K8 2-hydroxyisobutyryl.
Dot 9: H4K12 2-hydroxyisobutyryl. Dot 10: H4K16 L-lactyl.
Dot 11: H4K12 unmodified.
WB

Lysates: (-) HeLa cells; (+) HeLa cells treated with 100 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: 11 kDa
Observed band size: 11 kDa

Lysates: HeLa, NIH-3T3, BRL, Mouse liver
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: 11 kDa
Observed band size: 11 kDa
IHC-P

Tissue: Human testis
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-1411RM.

Tissue: Mouse liver
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-1411RM.

Tissue: Rat cerebrum
Section type: Formalin fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:1000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-1411RM.
IP

IP of HeLa+ sodium lactate (100 mM, 24 hours) extracts
Lane 1: 5% Input
Lane 2: IP with PTM-1411RM
Lane 3: IP with Rabbit mAb IgG Isotype Control
IP Ab incubation: 1:100 dilution, 4°C overnight
Blocking buffer: 5% NFDM/TBST
Dilution buffer: 5% NFDM/TBST
WB Primary Ab incubation: PTM-1411RM, 2 hours at room temperature, 1:500 dilution
Secondary Ab: Anti-Rabbit IgG for IP (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: 11 kDa
Observed band size: 11 kDa
ChIP

Sample: HeLa cells treated with 100 mM sodium lactate for 24 hours
Cross-linking conditions: no cross-linking
Amount of chromatin per IP: 5x106 cells
Amount of Ab per IP: 6 μg
Beads type and amount per IP: 50 μl of Protein A MagBeads
Description: Chromatin immunoprecipitations were performed with 6 μg of normal rabbit IgG as a negative control. The immunoprecipitated DNA was quantified by real-time PCR using primers specific for the human GAPDH-CDS, RPL30, LDHA promoter, LDHA CDS, FOXO3a promoter, FOXO3a downstream, RAB20 and TUBBP10 regions. The data are presented as enrichment of each sample relative to the total amount of input at each amplicon.

Research Use

For research use only, not for use in diagnostic procedures.

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References (59)
  • m5C-Modified tRF3b-CysGCA-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4
    Year 2026
    Journal Advanced Science
    Authors Xiaoling Ying, et al.
    Applications Unspecified
    Reactivity
  • Triptolide Inhibits Renal Fibrosis Through Promotion of PGC1α/PCK1-mediated Renal Gluconeogenesis
    Year 2026
    Journal Frontiers in Bioscience-Landmark
    Authors Yanzhe Wang, et al.
    Applications Unspecified
    Reactivity
  • Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion
    Year 2026
    Journal Theranostics
    Authors Jiangli Zhao, et al.
    Applications Unspecified
    Reactivity
  • Histone H4 lysine 5 lactylation: A key regulator of immune metabolism in microglia during ischemic stroke
    Year 2026
    Journal PHARMACOLOGICAL RESEARCH
    Authors Yishan Li, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression
    Year 2026
    Journal Frontiers in Immunology
    Authors Wenxin Da, et al.
    Applications Unspecified
    Reactivity
  • Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease
    Year 2026
    Journal International Journal of Biological Sciences
    Authors Shen Siman, et al.
    Applications Unspecified
    Reactivity
  • Butyrate ameliorates lung inflammation in chronic obstructive pulmonary disease in association with the regulation of histone lactylation: A mechanistic study
    Year 2025
    Journal LIFE SCIENCES
    Authors Min Jiang, et al.
    Applications Unspecified
    Reactivity
  • Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance
    Year 2025
    Journal Advanced Science
    Authors Jiyuan Tang, et al.
    Applications Unspecified
    Reactivity
  • H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2+ Treg recruitment
    Year 2025
    Journal EXPERIMENTAL AND MOLECULAR MEDICINE
    Authors Ye Linlin, et al.
    Applications Unspecified
    Reactivity
  • Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk
    Year 2025
    Journal Nature Communications
    Authors Bai Qin, et al.
    Applications Unspecified
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  • H3K18 lactylation potentiates microglial polarization via the TLR4 pathway in diabetes-induced cognitive impairment
    Year 2025
    Journal JCI Insight
    Authors Ying Yang, et al.
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  • Histone Lactylation-Mediated PAD4 Up-Regulation Promotes Septic Acute Kidney Injury via Activating NETosis
    Year 2025
    Journal NEPHROLOGY
    Authors Wen-lin Huang, et al.
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  • Sirtuin 6 is a histone delactylase
    Year 2025
    Journal JOURNAL OF BIOLOGICAL CHEMISTRY
    Authors Garrison A. Nickel, et al.
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  • TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation
    Year 2025
    Journal AGING CELL
    Authors Yue Wang, et al.
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  • H3K18 lactylation-hexokinase 2 positive feedback loop promotes osteogenesis of ASPCs in facial infiltrating lipomatosis
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    Journal Stem Cell Research & Therapy
    Authors Chen Hongrui, et al.
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  • Protocatechuic aldehyde promotes diabetic wound healing by enhancing angiogenesis via H3K18 lactylation-mediated Acvr1c expression
    Year 2025
    Journal MOLECULAR IMMUNOLOGY
    Authors Weijing Fan, et al.
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  • Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation
    Year 2025
    Journal CELL DEATH AND DIFFERENTIATION
    Authors Tang Youzhou, et al.
    Applications Unspecified
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  • Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1
    Year 2025
    Journal Journal of Advanced Research
    Authors Zhihao Liu, et al.
    Applications Unspecified
    Reactivity
  • H3K18 lactylation drives the progression of silica nanoparticles-induced pulmonary fibrosis via promoting macrophage M1 polarization
    Year 2025
    Journal JOURNAL OF HAZARDOUS MATERIALS
    Authors Lili Shi, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes collagen expression, proliferation and migration through H3K18 lactylation-dependent stimulation of LTBP3/TGF-β1 axis in keloid fibroblasts
    Year 2025
    Journal JOURNAL OF INVESTIGATIVE DERMATOLOGY
    Authors Jing-Jing Gu, et al.
    Applications Unspecified
    Reactivity
  • Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells
    Year 2025
    Journal ACS Chemical Biology
    Authors Xinlong Guo, et al.
    Applications Unspecified
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  • Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neurons
    Year 2025
    Journal Science Signaling
    Authors Yu-Tao Deng, et al.
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  • WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma
    Year 2025
    Journal Advanced Science
    Authors Tao Huang, et al.
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  • Histone lactylation-induced premature senescence contributes to 1-nitropyrene-Induced chronic obstructive pulmonary disease
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    Journal Redox Biology
    Authors Rong-Rong Wang, et al.
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  • Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury
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    Journal NEURON
    Authors Xuhui Ge, et al.
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  • Gastrodin attenuates rheumatoid arthritis by targeting KAT8 to inhibit the lactylation of H3K9
    Year 2025
    Journal Frontiers in Pharmacology
    Authors Yufang Dai, et al.
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    Journal Cell Death & Disease
    Authors Deng Jiao, et al.
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    Authors Zhao Xige, et al.
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    Year 2025
    Journal Autophagy
    Authors Lei Xu, et al.
    Applications Unspecified
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    Authors Songtao Liu, et al.
    Applications Unspecified
    Reactivity
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    Journal CELL DEATH AND DIFFERENTIATION
    Authors Xiong Junjun, et al.
    Applications Unspecified
    Reactivity
  • H4K12 lactylation potentiates mitochondrial oxidative stress via the Foxo1 pathway in diabetes-induced cognitive impairment
    Year 2025
    Journal Journal of Advanced Research
    Authors Ying Yang, et al.
    Applications Unspecified
    Reactivity
  • Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation-Mediated FGFR4 Activation
    Year 2025
    Journal Advanced Science
    Authors Zehua Ye, et al.
    Applications Unspecified
    Reactivity
  • The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease
    Year 2025
    Journal Cell Death & Disease
    Authors Sha Xudong, et al.
    Applications Unspecified
    Reactivity
  • Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson’s disease via histone lactylation
    Year 2025
    Journal npj Parkinsons Disease
    Authors Qin Qixiong, et al.
    Applications Unspecified
    Reactivity
  • DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation
    Year 2024
    Journal Journal of Molecular Cell Biology
    Authors Yang Yaqi, et al.
    Applications Unspecified
    Reactivity
  • Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
    Year 2024
    Journal Acta Pharmaceutica Sinica B
    Authors Han Liu, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance
    Year 2024
    Journal Nature Communications
    Authors Chen Zhuo, et al.
    Applications Unspecified
    Reactivity
  • NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells
    Year 2024
    Journal Molecular Brain
    Authors Cheng Jing, et al.
    Applications Unspecified
    Reactivity
  • GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation
    Year 2024
    Journal Journal of Translational Medicine
    Authors Liu Chenyang, et al.
    Applications Unspecified
    Reactivity
  • Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis
    Year 2024
    Journal iScience
    Authors Runhua Du, et al.
    Applications Unspecified
    Reactivity
  • H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
    Year 2024
    Journal Cell Reports
    Authors Ruijie Wang, et al.
    Applications Unspecified
    Reactivity
  • Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage
    Year 2024
    Journal Journal of Neuroinflammation
    Authors Zhang Fan, et al.
    Applications Unspecified
    Reactivity
  • Histone Lactylation Dynamics: Unlocking the Triad of Metabolism, Epigenetics, and Immune Regulation in Metastatic Cascade of Pancreatic Cancer
    Year 2024
    Journal CANCER LETTERS
    Authors Xing Wang, et al.
    Applications Unspecified
    Reactivity
  • A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
    Year 2024
    Journal GENOME BIOLOGY
    Authors Fan Wei, et al.
    Applications Unspecified
    Reactivity
  • Virus-Induced Histone Lactylation Promotes Virus Infection in Crustacean
    Year 2024
    Journal Advanced Science
    Authors Yu Zhang, et al.
    Applications Unspecified
    Reactivity
  • The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation
    Year 2024
    Journal Journal of Animal Science and Biotechnology
    Authors Wei Yaozong, et al.
    Applications Unspecified
    Reactivity
  • Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury
    Year 2024
    Journal Advanced Science
    Authors Jiao Qiao, et al.
    Applications Unspecified
    Reactivity
  • Lactylproteome analysis indicates histone H4K12 lactylation as a novel biomarker in triple-negative breast cancer
    Year 2024
    Journal Frontiers in Endocrinology
    Authors Cui Zhaolei, et al.
    Applications Unspecified
    Reactivity
  • Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
    Year 2023
    Journal Cell Metabolism
    Authors Hyunsoo Rho, et al.
    Applications Unspecified
    Reactivity
  • The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity
    Year 2023
    Journal Cell Metabolism
    Authors Xuedan Sun, et al.
    Applications Unspecified
    Reactivity
  • BRAFV600E restructures cellular lactylation to promote anaplastic thyroid cancer proliferation
    Year 2023
    Journal ENDOCRINE-RELATED CANCER
    Authors Xumeng Wang, et al.
    Applications Unspecified
    Reactivity
  • Progesterone activates histone lactylation-Hif1α-glycolysis feedback loop to promote decidualization
    Year 2023
    Journal ENDOCRINOLOGY
    Authors Zhao Wei, et al.
    Applications Unspecified
    Reactivity
  • STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia
    Year 2023
    Journal Signal Transduction and Targeted Therapy
    Authors Huang Ze-Wei, et al.
    Applications Unspecified
    Reactivity
  • Quantification of Global Histone Post Translational Modifications Using Intranuclear Flow Cytometry in Isolated Mouse Brain Microglia
    Year 2023
    Journal Jove-Journal of Visualized Experiments
    Authors Morgan Towriss, et al.
    Applications Unspecified
    Reactivity
  • H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
    Year 2023
    Journal Journal of Neuroinflammation
    Authors Wei Lin, et al.
    Applications Unspecified
    Reactivity
  • Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis
    Year 2023
    Journal Journal of Translational Medicine
    Authors Duan Wenzhe, et al.
    Applications Unspecified
    Reactivity
  • Lactate Activates Germline and Cleavage Embryo Genes in Mouse Embryonic Stem Cells
    Year 2022
    Journal Cells
    Authors Qing Tian, et al.
    Applications Unspecified
    Reactivity
  • Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization
    Year 2022
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Juan Lin, et al.
    Applications Unspecified
    Reactivity
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