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A Chiral Hydrogel Accelerates Wound Healing via the Lactylation of Ring Finger Protein 123
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Year
2026
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Journal
ACS Appl Mater Interfaces
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Authors
Ruizhe He, et al.
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Applications
Unspecified
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Reactivity
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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer
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Year
2026
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Journal
Cell Rep
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Authors
Guanghui Xu, et al.
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Applications
IAP
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Reactivity
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Lactylation omics of rabbit rotator cuff tear reveals differentially modified proteins and metabolic relating therapy targets
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Year
2026
-
Journal
Front Med (Lausanne)
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Authors
Tong Pan & Zhenlong Liu
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Applications
IAP
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Reactivity
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Profiling of Lysine Lactylation Reveals Its Proliferation-promoting Functions in Colorectal Cancer Cells
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Year
2026
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Journal
Anticancer Res
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Authors
Zaikui Zhang, et al.
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Applications
IAP
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Reactivity
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Lactate-mediated Ran lactylation at lysine 123 promotes astrocytes polarization after oxygen-glucose deprivation/reoxygenation
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Year
2026
-
Journal
Int Immunopharmacol.
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Authors
Zhiqiang Wang, et al.
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Applications
IAP
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Reactivity
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E2F1-mediated 53BP2 lactylation stabilizes p53 to induce cochlear hair cell apoptosis in mouse age-related hearing loss
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Year
2026
-
Journal
Clin Epigenetics
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Authors
Xiaoqin Luo, et al.
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Applications
IAP
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Reactivity
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Mass Spectrometry-based Lactylome and Confirmation of Lactylated Proteins
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Year
2026
-
Journal
J. Vis. Exp.
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Authors
Maude Hamilton, et al.
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Applications
IAP
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Reactivity
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High-intensity interval training and moderate-intensity continuous training improve hippocampal synaptic plasticity in Alzheimer's disease via differential lactylation
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Year
2026
-
Journal
Exp Neurol
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Authors
Liming Chen, et al.
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Applications
IAP
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Reactivity
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FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression
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Year
2026
-
Journal
Cell Death Discov
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Authors
Zikai Guo, et al.
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Applications
IAP
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Reactivity
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A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional regulation in humans and mice
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Year
2026
-
Journal
Nucleic Acids Res
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Authors
Tiechao Ruan, et al.
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Applications
IAP
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Reactivity
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Lactylome Reprogramming Mediates Therapeutic Response and Adaptation to Neoadjuvant Chemotherapy in Esophageal Squamous Cell Carcinoma
-
Year
2026
-
Journal
Mol Cell Proteomics
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Authors
Panpan Peng, et al.
-
Applications
IAP
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Reactivity
-
LDHB K156 lactylation links cGAS–STING–mediated metabolic reprogramming to NLRP3 inflammasome activation in sepsis-associated acute kidney injury
-
Year
2026
-
Journal
Life Sci
-
Authors
Mengyuan Luo, et al.
-
Applications
IAP
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Reactivity
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ENO1 lactylation drives bevacizumab resistance through metabolic reprogramming and angiogenesis in ovarian cancer
-
Year
2026
-
Journal
Drug Resist Updat
-
Authors
Tian Zeng, et al.
-
Applications
IAP
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Reactivity
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Characterization of protein lactylation in healthy and ischemic mouse hearts
-
Year
2025
-
Journal
Front Cardiovasc Med
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Authors
Daiqian Wu, et al.
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Applications
Unspecified
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Reactivity
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Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia
-
Year
2025
-
Journal
Front Neurol
-
Authors
Yinghua Chen, et al.
-
Applications
Unspecified
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Reactivity
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Flipping the Switch: MeCP2-Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation
-
Year
2025
-
Journal
Adv Sci (Weinh)
-
Authors
Zengyu Zhang, et al.
-
Applications
Unspecified
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Reactivity
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GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer
-
Year
2025
-
Journal
Cell Rep
-
Authors
Yubin Chen, et al.
-
Applications
Unspecified
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Reactivity
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Ginsenoside Rk1 suppresses the epithelial-mesenchymal transition of hepatic stellate cells via PFKFB2-mediated aerobic glycolysis
-
Year
2025
-
Journal
Chem Biol Interact
-
Authors
Mengyuan Li, et al.
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Applications
Unspecified
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Reactivity
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H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer
-
Year
2025
-
Journal
J Exp Clin Cancer Res
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Authors
Liu Jiena, et al.
-
Applications
IAP
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Reactivity
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Integrated analysis of lactylation modification and proteomics revealed potential epigenetic regulation in intramuscular fat deposition of Xidu black pigs
-
Year
2025
-
Journal
BMC Genomics
-
Authors
Chen Tong, et al.
-
Applications
Unspecified
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Reactivity
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Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation
-
Year
2025
-
Journal
Cell Death Differ
-
Authors
Tang Youzhou, et al.
-
Applications
IAP
-
Reactivity
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Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair
-
Year
2025
-
Journal
Signal Transduct Target Ther
-
Authors
Li Xinyuan, et al.
-
Applications
Unspecified
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Reactivity
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Lactate-functionalized 3D-printed PCL/nHA scaffold drives BMSC osteogenesis via metabolic-epigenetic crosstalk
-
Year
2025
-
Journal
Mater Today Bio
-
Authors
Min Zeng, et al.
-
Applications
IAP
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Reactivity
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Lactylated proteomic analysis reveals functional implications of lysine lactylation in asthenozoospermia
-
Year
2025
-
Journal
Mol Cell Proteomics
-
Authors
Minghao Yan, et al.
-
Applications
IAP
-
Reactivity
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Lactylation of Mitochondrial Adenosine Triphosphate Synthase Subunit Alpha Regulates Vascular Remodeling and Progression of Aortic Dissection
-
Year
2025
-
Journal
Research (Wash D C)
-
Authors
Tao Yu, et al.
-
Applications
Unspecified
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Reactivity
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Lactylation-Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22-Mediated Dephosphorylation of NLRP3
-
Year
2025
-
Journal
Adv Sci (Weinh)
-
Authors
Feng Zhang, et al.
-
Applications
Unspecified
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Reactivity
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Lactylome Profiling Reveals the Potential Role of Lysine Lactylation in Regulating Soybean Seed Quality
-
Year
2025
-
Journal
J Agric Food Chem
-
Authors
Chang Xu, et al.
-
Applications
Unspecified
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Reactivity
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Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model
-
Year
2025
-
Journal
Front Cell Dev Biol
-
Authors
Wenyu Zhuo, et al.
-
Applications
IAP
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Reactivity
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Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue
-
Year
2025
-
Journal
Front Cell Dev Biol
-
Authors
Jiahui Chang, et al.
-
Applications
Unspecified
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Reactivity
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Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
-
Year
2025
-
Journal
Cell Res
-
Authors
Zhao Qihang, et al.
-
Applications
Unspecified
-
Reactivity
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Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function
-
Year
2025
-
Journal
Nat Commun
-
Authors
Yu Haitao, et al.
-
Applications
Unspecified
-
Reactivity
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Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis
-
Year
2025
-
Journal
Cell Rep
-
Authors
Yunfei Zhou, et al.
-
Applications
Unspecified
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Reactivity
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PRMT5 K240lac confers ferroptosis resistance via ALKBH5/SLC7A11 axis in colorectal cancer
-
Year
2025
-
Journal
Oncogene
-
Authors
Qu Shuang, et al.
-
Applications
IAP
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Reactivity
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Protocol for label-free quantitative lysine lactylproteome profiling
-
Year
2025
-
Journal
STAR Protoc
-
Authors
Yu Ran, et al.
-
Applications
Unspecified
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Reactivity
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Serpina3k lactylation protects from cardiac ischemia reperfusion injury
-
Year
2025
-
Journal
Nat Commun
-
Authors
Wang Le, et al.
-
Applications
Unspecified
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Reactivity
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SLC4A7 suppresses lung adenocarcinoma oncogenesis by reducing lactate transport and protein lactylation
-
Year
2025
-
Journal
Int J Oncol
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Authors
Haojie Yan, et al.
-
Applications
Unspecified
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Reactivity
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Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment
-
Year
2025
-
Journal
Nat Immunol
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Authors
Jin Jing, et al.
-
Applications
IAP
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Reactivity
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The overview of lactylation in the placenta of preeclampsia
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Year
2025
-
Journal
Placenta
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Authors
Qiaoli Feng, et al.
-
Applications
Unspecified
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Reactivity
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ZNF207-driven PRDX1 lactylation and NRF2 activation in regorafenib resistance and ferroptosis evasion
-
Year
2025
-
Journal
Drug Resist Updat
-
Authors
Tianfeng Yang, et al.
-
Applications
Unspecified
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Reactivity
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Epigenetic regulation of cardiac tissue development by lysine lactylation
-
Year
2025
-
Journal
hLife
-
Authors
Xiaodong Luan, et al.
-
Applications
Unspecified
-
Reactivity
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Deciphering novel enzymatic and non-enzymatic lysine lactylation inSalmonella
-
Year
2025
-
Journal
Emerg Microbes Infect
-
Authors
Chuanzhen Zhang, et al.
-
Applications
IAP
-
Reactivity
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Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients
-
Year
2025
-
Journal
J Proteome Res
-
Authors
Jiaqi Hu, et al.
-
Applications
Unspecified
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Reactivity
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Lactylation of CREB is required for FSH-induced proliferation and differentiation of ovarian granulosa cells
-
Year
2025
-
Journal
Nucleic Acids Res
-
Authors
Gang Wu, et al.
-
Applications
IAP
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Reactivity
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Global profiling of protein lactylome in porcine granulosa cells
-
Year
2025
-
Journal
J Ovarian Res
-
Authors
Fan Shuhao, et al.
-
Applications
IAP
-
Reactivity
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Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell
-
Year
2025
-
Journal
Sci Rep
-
Authors
He Jiang, et al.
-
Applications
IAP
-
Reactivity
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AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
-
Year
2024
-
Journal
Nature
-
Authors
Li Heyu, et al.
-
Applications
Unspecified
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Reactivity
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ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
-
Year
2024
-
Journal
Diabetologia
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Authors
Chen Jingfang, et al.
-
Applications
Unspecified
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Reactivity
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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
-
Year
2024
-
Journal
Cell
-
Authors
Zhi Zong, et al.
-
Applications
Unspecified
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Reactivity
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Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption
-
Year
2024
-
Journal
Adv Sci (Weinh)
-
Authors
Fan Ouyang, et al.
-
Applications
IAP
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Reactivity
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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
-
Year
2024
-
Journal
Cell Metab
-
Authors
Jian Zhou, et al.
-
Applications
IAP
-
Reactivity
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Comprehensive analysis of lysine lactylation and its potential biological significance in clear cell renal cell carcinoma
-
Year
2024
-
Journal
Eur J Med Res
-
Authors
Bangbei Wan, et al.
-
Applications
IAP
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Reactivity
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Global profiling of protein lactylation in microglia in experimental high-altitude cerebral edema
-
Year
2024
-
Journal
Cell Commun Signal
-
Authors
Jiang Xiufang, et al.
-
Applications
IAP
-
Reactivity
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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma
-
Year
2024
-
Journal
Immunity
-
Authors
Alessandra De Leo, et al.
-
Applications
Unspecified
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Reactivity
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HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription
-
Year
2024
-
Journal
Nat Commun
-
Authors
Niu Ziping, et al.
-
Applications
Unspecified
-
Reactivity
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Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development
-
Year
2024
-
Journal
J Proteome Res
-
Authors
Enyuan Zhang, et al.
-
Applications
IAP
-
Reactivity
-
Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis
-
Year
2024
-
Journal
Adv Sci (Weinh)
-
Authors
Jian Chen, et al.
-
Applications
IAP
-
Reactivity
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Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity
-
Year
2024
-
Journal
J Cell Biol
-
Authors
Yewei Huang, et al.
-
Applications
Unspecified
-
Reactivity
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Lactylation-Driven IGF2BP3-Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC
-
Year
2024
-
Journal
Adv Sci (Weinh)
-
Authors
Yuanxiang Lu, et al.
-
Applications
Unspecified
-
Reactivity
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Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia
-
Year
2024
-
Journal
Cell Signal
-
Authors
Fan Song, et al.
-
Applications
IAP
-
Reactivity
-
Lactylproteome analysis indicates histone H4K12 lactylation as a novel biomarker in triple-negative breast cancer
-
Year
2024
-
Journal
Front Endocrinol (Lausanne)
-
Authors
Cui Zhaolei, et al.
-
Applications
IAP
-
Reactivity
-
Lysine lactylation-based insight to understanding the characterization of cervical cancer
-
Year
2024
-
Journal
Biochim Biophys Acta Mol Basis Dis
-
Authors
Chaoran He, et al.
-
Applications
Unspecified
-
Reactivity
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Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis
-
Year
2024
-
Journal
Theranostics
-
Authors
Liangqi Chen, et al.
-
Applications
Unspecified
-
Reactivity
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Multi-omics explores the potential regulatory role of acetylation modification in flavonoid biosynthesis of Ginkgo biloba
-
Year
2024
-
Journal
Tree Physiol
-
Authors
Liu Xiaomeng, et al.
-
Applications
Unspecified
-
Reactivity
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Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma
-
Year
2024
-
Journal
Genome Biol
-
Authors
Jing Fengyang, et al.
-
Applications
IAP
-
Reactivity
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Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
-
Year
2024
-
Journal
Cell Metab
-
Authors
Ruilong Liu, et al.
-
Applications
IAP
-
Reactivity
-
Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
-
Year
2024
-
Journal
J Hepatol
-
Authors
Long Yang, et al.
-
Applications
Unspecified
-
Reactivity
-
p53 lysine-lactylated modification contributes to lipopolysaccharide-induced proinflammatory activation in BV2 cell under hypoxic conditions
-
Year
2024
-
Journal
Neurochem Int
-
Authors
Xuechao Fei, et al.
-
Applications
IAP
-
Reactivity
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Post-translational toxin modification by lactate controls Staphylococcus aureus virulence
-
Year
2024
-
Journal
Nat Commun
-
Authors
Wang Yanan, et al.
-
Applications
Unspecified
-
Reactivity
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Protein Lactylation Profiles Provide Insights into Molecular Mechanisms Underlying Metabolism in Yak
-
Year
2024
-
Journal
J Agric Food Chem
-
Authors
Zhijuan Wu, et al.
-
Applications
Unspecified
-
Reactivity
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PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis
-
Year
2024
-
Journal
Cancer Res
-
Authors
Zhou Zijian, et al.
-
Applications
Unspecified
-
Reactivity
-
Systematic Analysis of Lysine Lactylation in Nucleus Pulposus Cells
-
Year
2024
-
Journal
iScience
-
Authors
Lei Sheng, et al.
-
Applications
IAP
-
Reactivity
-
Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury
-
Year
2024
-
Journal
Cell Death Differ
-
Authors
Weng Weiji, et al.
-
Applications
Unspecified
-
Reactivity
-
Lactylome Analysis Reveals Potential Target Modified Proteins in the Retina of Form-deprivation Myopia
-
Year
2024
-
Journal
iScience
-
Authors
Jiaojiao Feng, et al.
-
Applications
IAP
-
Reactivity
-
Lactylation of Hdac1 regulated by Ldh prevents the pluripotent-to-2C state conversion
-
Year
2024
-
Journal
Stem Cell Res Ther
-
Authors
Dong Qiman, et al.
-
Applications
IAP
-
Reactivity
-
Effects of moderate intensity exercise on liver metabolism in mice based on multi-omics analysis
-
Year
2024
-
Journal
Sci Rep
-
Authors
Fang Wang, et al..
-
Applications
IAP
-
Reactivity
-
cKMT1 is a New Lysine Methyltransferase That Methylates the Ferredoxin-NADP(+) Oxidoreductase and Regulates Energy Transfer in Cyanobacteria
-
Year
2023
-
Journal
Mol Cell Proteomics
-
Authors
Gaoxiang Cao, et al.
-
Applications
Unspecified
-
Reactivity
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Deciphering the Atlas of Post-Translational Modification in Sugarcane
-
Year
2023
-
Journal
J Agric Food Chem
-
Authors
Qibin Wu, et al.
-
Applications
IAP
-
Reactivity
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Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells
-
Year
2023
-
Journal
J Proteome Res
-
Authors
Eunji Sung, et al.
-
Applications
Unspecified
-
Reactivity
-
Global profiling of protein lactylation in Caenorhabditis elegans
-
Year
2023
-
Journal
Proteomics
-
Authors
Tao Ding, et al.
-
Applications
Unspecified
-
Reactivity
-
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease
-
Year
2023
-
Journal
Hepatology
-
Authors
Gao Ruxin, et al.
-
Applications
IAP
-
Reactivity
-
Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy
-
Year
2023
-
Journal
J Proteome Res
-
Authors
Yuan Lin, et al.
-
Applications
Unspecified
-
Reactivity
-
Novel Insight of Nitrogen Deprivation Affected Lipid Accumulation by Genome-Wide Lactylation in Nannochloropsis oceanica
-
Year
2023
-
Journal
J Agric Food Chem
-
Authors
Jiao Wang, et al.
-
Applications
Unspecified
-
Reactivity
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α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
-
Year
2023
-
Journal
Cell Res
-
Authors
Zhang Naijin, et al.
-
Applications
Unspecified
-
Reactivity
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High-Intensity Interval Training Induces Protein Lactylation in Different Tissues of Mice with Specificity and Time Dependence
-
Year
2023
-
Journal
Metabolites
-
Authors
Wenhua Huang, et al.
-
Applications
IAP
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Reactivity
-
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma
-
Year
2023
-
Journal
Nat Metab
-
Authors
Zijian Yang, et al.
-
Applications
IAP
-
Reactivity
-
Post-translational changes in Phialophora verrucosa via lysine lactylation during prolonged presence in a patient with a CARD9-related immune disorder
-
Year
2022
-
Journal
Front Immunol
-
Authors
Yinggai Song, et al.
-
Applications
Unspecified
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Reactivity
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Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii
-
Year
2022
-
Journal
Genomics Proteomics Bioinformatics
-
Authors
Deqi Yin, et al.
-
Applications
IAP
-
Reactivity
-
Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii
-
Year
2022
-
Journal
Parasit Vectors
-
Authors
Zhao Wei, et al.
-
Applications
IAP
-
Reactivity
-
YiaC and CobB regulate lysine lactylation in Escherichia coli
-
Year
2022
-
Journal
Nat Commun
-
Authors
Dong Hanyang, et al.
-
Applications
Unspecified
-
Reactivity
-
Lactate-derived HDAC6 Lactylation as a new target for neuronal protection in cerebral ischemic reperfusion injury
-
Year
2022
-
Journal
bioRxiv
-
Authors
Jun Cao, et al.
-
Applications
IAP
-
Reactivity
-
Lactylation of HADHA Promotes Sepsis-Induced Myocardial Depression
-
Year
-
Journal
Circ Res
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Authors
Tie-Ning Zhang, et al.
-
Applications
IAP
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Reactivity
