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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer
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Year
2026
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Journal
Cell Reports
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Authors
Guanghui Xu, et al.
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Applications
Unspecified
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Reactivity
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A Chiral Hydrogel Accelerates Wound Healing via the Lactylation of Ring Finger Protein 123
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Year
2026
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Journal
ACS Applied Materials & Interfaces
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Authors
Ruizhe He, et al.
-
Applications
Unspecified
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Reactivity
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Flipping the Switch: MeCP2-Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation
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Year
2025
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Journal
Advanced Science
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Authors
Zengyu Zhang, et al.
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Applications
Unspecified
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Reactivity
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Integrated analysis of lactylation modification and proteomics revealed potential epigenetic regulation in intramuscular fat deposition of Xidu black pigs
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Year
2025
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Journal
BMC GENOMICS
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Authors
Chen Tong, et al.
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Applications
Unspecified
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Reactivity
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Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function
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Year
2025
-
Journal
Nature Communications
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Authors
Yu Haitao, et al.
-
Applications
Unspecified
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Reactivity
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Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis
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Year
2025
-
Journal
Cell Reports
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Authors
Yunfei Zhou, et al.
-
Applications
Unspecified
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Reactivity
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Lactylation-Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22-Mediated Dephosphorylation of NLRP3
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Year
2025
-
Journal
Advanced Science
-
Authors
Feng Zhang, et al.
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Applications
Unspecified
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Reactivity
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Lactylated proteomic analysis reveals functional implications of lysine lactylation in asthenozoospermia
-
Year
2025
-
Journal
MOLECULAR & CELLULAR PROTEOMICS
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Authors
Minghao Yan, et al.
-
Applications
Unspecified
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Reactivity
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Ginsenoside Rk1 suppresses the epithelial-mesenchymal transition of hepatic stellate cells via PFKFB2-mediated aerobic glycolysis
-
Year
2025
-
Journal
CHEMICO-BIOLOGICAL INTERACTIONS
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Authors
Mengyuan Li, et al.
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Applications
Unspecified
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Reactivity
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Characterization of protein lactylation in healthy and ischemic mouse hearts
-
Year
2025
-
Journal
Frontiers in Cardiovascular Medicine
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Authors
Daiqian Wu, et al.
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Applications
Unspecified
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Reactivity
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Bioinformatics Analysis and Experimental Validation of Lactylation Related Genes in Lung Adenocarcinoma
-
Year
2025
-
Journal
Cancer Management and Research
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Authors
Li Gao, et al.
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Applications
Unspecified
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Reactivity
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Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia
-
Year
2025
-
Journal
Frontiers in Neurology
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Authors
Yinghua Chen, et al.
-
Applications
Unspecified
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Reactivity
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H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer
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Year
2025
-
Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
-
Authors
Liu Jiena, et al.
-
Applications
Unspecified
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Reactivity
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Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation
-
Year
2025
-
Journal
CELL DEATH AND DIFFERENTIATION
-
Authors
Tang Youzhou, et al.
-
Applications
Unspecified
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Reactivity
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Lactylation of Mitochondrial Adenosine Triphosphate Synthase Subunit Alpha Regulates Vascular Remodeling and Progression of Aortic Dissection
-
Year
2025
-
Journal
Research
-
Authors
Tao Yu, et al.
-
Applications
Unspecified
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Reactivity
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Lactate-functionalized 3D-printed PCL/nHA scaffold drives BMSC osteogenesis via metabolic-epigenetic crosstalk
-
Year
2025
-
Journal
Materials Today Bio
-
Authors
Min Zeng, et al.
-
Applications
Unspecified
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Reactivity
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ZNF207-driven PRDX1 lactylation and NRF2 activation in regorafenib resistance and ferroptosis evasion
-
Year
2025
-
Journal
DRUG RESISTANCE UPDATES
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Authors
Tianfeng Yang, et al.
-
Applications
Unspecified
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Reactivity
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Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair
-
Year
2025
-
Journal
Signal Transduction and Targeted Therapy
-
Authors
Li Xinyuan, et al.
-
Applications
Unspecified
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Reactivity
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Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment
-
Year
2025
-
Journal
NATURE IMMUNOLOGY
-
Authors
Jin Jing, et al.
-
Applications
Unspecified
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Reactivity
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GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer
-
Year
2025
-
Journal
Cell Reports
-
Authors
Yubin Chen, et al.
-
Applications
Unspecified
-
Reactivity
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PRMT5 K240lac confers ferroptosis resistance via ALKBH5/SLC7A11 axis in colorectal cancer
-
Year
2025
-
Journal
ONCOGENE
-
Authors
Qu Shuang, et al.
-
Applications
Unspecified
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Reactivity
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Lactylome Profiling Reveals the Potential Role of Lysine Lactylation in Regulating Soybean Seed Quality
-
Year
2025
-
Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
-
Authors
Chang Xu, et al.
-
Applications
Unspecified
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Reactivity
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Protocol for label-free quantitative lysine lactylproteome profiling
-
Year
2025
-
Journal
STAR Protocols
-
Authors
Yu Ran, et al.
-
Applications
Unspecified
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Reactivity
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SLC4A7 suppresses lung adenocarcinoma oncogenesis by reducing lactate transport and protein lactylation
-
Year
2025
-
Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
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Authors
Haojie Yan, et al.
-
Applications
Unspecified
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Reactivity
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Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model
-
Year
2025
-
Journal
Frontiers in Cell and Developmental Biology
-
Authors
Wenyu Zhuo, et al.
-
Applications
Unspecified
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Reactivity
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Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue
-
Year
2025
-
Journal
Frontiers in Cell and Developmental Biology
-
Authors
Jiahui Chang, et al.
-
Applications
Unspecified
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Reactivity
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Serpina3k lactylation protects from cardiac ischemia reperfusion injury
-
Year
2025
-
Journal
Nature Communications
-
Authors
Wang Le, et al.
-
Applications
Unspecified
-
Reactivity
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Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
-
Year
2025
-
Journal
CELL RESEARCH
-
Authors
Zhao Qihang, et al.
-
Applications
Unspecified
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Reactivity
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The overview of lactylation in the placenta of preeclampsia
-
Year
2025
-
Journal
PLACENTA
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Authors
Qiaoli Feng, et al.
-
Applications
Unspecified
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Reactivity
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Comprehensive analysis of lysine lactylation and its potential biological significance in clear cell renal cell carcinoma
-
Year
2024
-
Journal
EUROPEAN JOURNAL OF MEDICAL RESEARCH
-
Authors
Bangbei Wan, et al.
-
Applications
Unspecified
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Reactivity
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Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
-
Year
2024
-
Journal
Cell Metabolism
-
Authors
Ruilong Liu, et al.
-
Applications
Unspecified
-
Reactivity
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PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis
-
Year
2024
-
Journal
CANCER RESEARCH
-
Authors
Zhou Zijian, et al.
-
Applications
Unspecified
-
Reactivity
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Post-translational toxin modification by lactate controls Staphylococcus aureus virulence
-
Year
2024
-
Journal
Nature Communications
-
Authors
Wang Yanan, et al.
-
Applications
Unspecified
-
Reactivity
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Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury
-
Year
2024
-
Journal
CELL DEATH AND DIFFERENTIATION
-
Authors
Weng Weiji, et al.
-
Applications
Unspecified
-
Reactivity
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Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption
-
Year
2024
-
Journal
Advanced Science
-
Authors
Fan Ouyang, et al.
-
Applications
Unspecified
-
Reactivity
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Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity
-
Year
2024
-
Journal
JOURNAL OF CELL BIOLOGY
-
Authors
Yewei Huang, et al.
-
Applications
Unspecified
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Reactivity
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Lactylation-Driven IGF2BP3-Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC
-
Year
2024
-
Journal
Advanced Science
-
Authors
Yuanxiang Lu, et al.
-
Applications
Unspecified
-
Reactivity
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Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma
-
Year
2024
-
Journal
GENOME BIOLOGY
-
Authors
Jing Fengyang, et al.
-
Applications
Unspecified
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Reactivity
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Systematic Analysis of Lysine Lactylation in Nucleus Pulposus Cells
-
Year
2024
-
Journal
iScience
-
Authors
Lei Sheng, et al.
-
Applications
Unspecified
-
Reactivity
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AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
-
Year
2024
-
Journal
NATURE
-
Authors
Li Heyu, et al.
-
Applications
Unspecified
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Reactivity
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Global profiling of protein lactylation in microglia in experimental high-altitude cerebral edema
-
Year
2024
-
Journal
Cell Communication and Signaling
-
Authors
Jiang Xiufang, et al.
-
Applications
Unspecified
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Reactivity
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Lysine lactylation-based insight to understanding the characterization of cervical cancer
-
Year
2024
-
Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
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Authors
Chaoran He, et al.
-
Applications
Unspecified
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Reactivity
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Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development
-
Year
2024
-
Journal
JOURNAL OF PROTEOME RESEARCH
-
Authors
Enyuan Zhang, et al.
-
Applications
Unspecified
-
Reactivity
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Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis
-
Year
2024
-
Journal
Advanced Science
-
Authors
Jian Chen, et al.
-
Applications
Unspecified
-
Reactivity
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Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis
-
Year
2024
-
Journal
Theranostics
-
Authors
Liangqi Chen, et al.
-
Applications
Unspecified
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Reactivity
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p53 lysine-lactylated modification contributes to lipopolysaccharide-induced proinflammatory activation in BV2 cell under hypoxic conditions
-
Year
2024
-
Journal
NEUROCHEMISTRY INTERNATIONAL
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Authors
Xuechao Fei, et al.
-
Applications
Unspecified
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Reactivity
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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
-
Year
2024
-
Journal
Cell Metabolism
-
Authors
Jian Zhou, et al.
-
Applications
Unspecified
-
Reactivity
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Protein Lactylation Profiles Provide Insights into Molecular Mechanisms Underlying Metabolism in Yak
-
Year
2024
-
Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
-
Authors
Zhijuan Wu, et al.
-
Applications
Unspecified
-
Reactivity
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Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia
-
Year
2024
-
Journal
CELLULAR SIGNALLING
-
Authors
Fan Song, et al.
-
Applications
Unspecified
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Reactivity
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Multi-omics explores the potential regulatory role of acetylation modification in flavonoid biosynthesis of Ginkgo biloba
-
Year
2024
-
Journal
TREE PHYSIOLOGY
-
Authors
Liu Xiaomeng, et al.
-
Applications
Unspecified
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Reactivity
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Lactylproteome analysis indicates histone H4K12 lactylation as a novel biomarker in triple-negative breast cancer
-
Year
2024
-
Journal
Frontiers in Endocrinology
-
Authors
Cui Zhaolei, et al.
-
Applications
Unspecified
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Reactivity
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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma
-
Year
2024
-
Journal
IMMUNITY
-
Authors
Alessandra De Leo, et al.
-
Applications
Unspecified
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Reactivity
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ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
-
Year
2024
-
Journal
DIABETOLOGIA
-
Authors
Chen Jingfang, et al.
-
Applications
Unspecified
-
Reactivity
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Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
-
Year
2024
-
Journal
JOURNAL OF HEPATOLOGY
-
Authors
Long Yang, et al.
-
Applications
Unspecified
-
Reactivity
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HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription
-
Year
2024
-
Journal
Nature Communications
-
Authors
Niu Ziping, et al.
-
Applications
Unspecified
-
Reactivity
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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
-
Year
2024
-
Journal
CELL
-
Authors
Zhi Zong, et al.
-
Applications
Unspecified
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Reactivity
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α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
-
Year
2023
-
Journal
CELL RESEARCH
-
Authors
Zhang Naijin, et al.
-
Applications
Unspecified
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Reactivity
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Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease
-
Year
2023
-
Journal
HEPATOLOGY
-
Authors
Gao Ruxin, et al.
-
Applications
Unspecified
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Reactivity
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cKMT1 is a new lysine methyltransferase that methylates the ferredoxin-NADP(+) oxidoreductase (FNR) and regulates energy transfer in cyanobacteria
-
Year
2023
-
Journal
MOLECULAR & CELLULAR PROTEOMICS
-
Authors
Gaoxiang Cao, et al.
-
Applications
Unspecified
-
Reactivity
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Novel Insight of Nitrogen Deprivation Affected Lipid Accumulation by Genome-Wide Lactylation in Nannochloropsis oceanica
-
Year
2023
-
Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
-
Authors
Jiao Wang, et al.
-
Applications
Unspecified
-
Reactivity
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Deciphering the Atlas of Post-Translational Modification in Sugarcane
-
Year
2023
-
Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
-
Authors
Qibin Wu, et al.
-
Applications
Unspecified
-
Reactivity
-
Lactylome Analyses Suggest Systematic Lysine-Lactylated Substrates in Oral Squamous Cell Carcinoma Under Normoxia and Hypoxia
-
Year
2023
-
Journal
iScience
-
Authors
Song Fan, et al.
-
Applications
Unspecified
-
Reactivity
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Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy
-
Year
2023
-
Journal
JOURNAL OF PROTEOME RESEARCH
-
Authors
Yuan Lin, et al.
-
Applications
Unspecified
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Reactivity
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Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells
-
Year
2023
-
Journal
JOURNAL OF PROTEOME RESEARCH
-
Authors
Eunji Sung, et al.
-
Applications
Unspecified
-
Reactivity
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Global profiling of protein lactylation in Caenorhabditis elegans
-
Year
2023
-
Journal
PROTEOMICS
-
Authors
Tao Ding, et al.
-
Applications
Unspecified
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Reactivity
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cKMT1 is a New Lysine Methyltransferase That Methylates the Ferredoxin-NADP(+) Oxidoreductase and Regulates Energy Transfer in Cyanobacteria
-
Year
2023
-
Journal
MOLECULAR & CELLULAR PROTEOMICS
-
Authors
Gaoxiang Cao, et al.
-
Applications
Unspecified
-
Reactivity
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YiaC and CobB regulate lysine lactylation in Escherichia coli
-
Year
2022
-
Journal
Nature Communications
-
Authors
Dong Hanyang, et al.
-
Applications
Unspecified
-
Reactivity
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Post-translational changes in Phialophora verrucosa via lysine lactylation during prolonged presence in a patient with a CARD9-related immune disorder
-
Year
2022
-
Journal
Frontiers in Immunology
-
Authors
Yinggai Song, et al.
-
Applications
Unspecified
-
Reactivity
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Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii
-
Year
2022
-
Journal
GENOMICS PROTEOMICS & BIOINFORMATICS
-
Authors
Deqi Yin, et al.
-
Applications
Unspecified
-
Reactivity
-
Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii
-
Year
2022
-
Journal
Parasites & Vectors
-
Authors
Zhao Wei, et al.
-
Applications
Unspecified
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Reactivity
