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Anti-L-Lactyllysine Rabbit pAb
Catalog Number: PTM-1401
$ 435

Clone Number: /

Host: Rabbit Clonality: Polyclonal

Applications： WB FC

Reactivity: All

Synonyms: Kla, L-la

Product Size
100 μl

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms Kla, L-la
UniProt ID

/

Immunogen L-lactylated lysine peptides
MW (kDa) Multiple
Specificity Anti-L-Lactyllysine Rabbit pAb detects proteins with L-lactylated lysine residues. This pan antibody recognizes L-lactylated lysine independent of its surrounding sequences.
Product Usage Information
Applications Dilution Recommended Species
WB 1:500 - 1:1000 All
FC 1:50 Human
Properties
Purity Protein A and immunogen affinity purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

Lactate, previously recognized solely as an energy source and metabolic byproduct, has now emerged as a crucial player in cancer biology, especially within the scope of the Warburg effect and its intricate interplay with various cellular processes, including angiogenesis, hypoxia, polarization of macrophages, and T cell activation. Recent investigations have unveiled an unprecedented function of lactate in the realm of histone modification, specifically through lysine L-lactylation, which exerts regulatory control over gene expression. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The acetyltransferase p300 is responsible for introducing lysine L-lactylation, while Class I histone deacetylases (HDAC 1-3) have been identified as an eraser of the lactylation marks on histones. Although initially identified on histone proteins, L-lactylation has since been detected on a broad range of non-histone substrates. Among the known isomers, including D-lactylation and N-ε-carboxyethylation, L-lactylation is the predominant form found in cells and the major participant in glycolysis and the Warburg effect.

Cellular location

/

Images
Dot Blot

Peptide amount: 4 ng, 20 ng, 100 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
The list of peptides used in the experiment is provided in the table below:
WB

Lysates: (-) HeLa cells; (+) HeLa cells treated with 100 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: Mouse kidney, mouse spleen
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: HeLa, N2a, BRL
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: Multiple
Observed band size: Multiple
FC

Sample: HeLa cells
Fixative: 4% Paraformaldehyde
Permeabilization: 0.1% Triton X-100
Primary Ab dilution: 1:50
Secondary Ab: Goat Anti-Rabbit IgG
Unlabeled control: The cell without incubation with primary antibody and secondary antibody (black line).
Isotype control: Rabbit mAb IgG Isotype Control (blue line).
Description: The red line represents the positive signal observed with PTM-1401.

Research Use

For research use only, not for use in diagnostic procedures.

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References (137)
  • Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension
    Year 2026
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Xingbing Li, et al.
    Applications Unspecified
    Reactivity
  • Histone H3K9 Lactylation Activates the TXNIP/NLRP3 Pathway to Drive Macrophage Inflammation after Spinal Cord Injury
    Year 2026
    Journal Redox Biology
    Authors Chaoran Shi, et al.
    Applications Unspecified
    Reactivity
  • NAA20-mediated ACF1 lactylation drives neuroblastoma progression through enhancing GCLM-dependent glutathione synthesis
    Year 2026
    Journal CELL BIOLOGY AND TOXICOLOGY
    Authors Bingqiang Han, et al.
    Applications Unspecified
    Reactivity
  • Histone H4 lysine 5 lactylation: A key regulator of immune metabolism in microglia during ischemic stroke
    Year 2026
    Journal PHARMACOLOGICAL RESEARCH
    Authors Yishan Li, et al.
    Applications Unspecified
    Reactivity
  • Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells
    Year 2026
    Journal Frontiers in Cellular and Infection Microbiology
    Authors Qinrui Wu, et al.
    Applications Unspecified
    Reactivity
  • Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease
    Year 2026
    Journal International Journal of Biological Sciences
    Authors Shen Siman, et al.
    Applications Unspecified
    Reactivity
  • HSPA8 lactylation attenuates neuronal pyroptosis via E3 ligase-mediated NLRP3 degradation after ischemic stroke
    Year 2026
    Journal APOPTOSIS
    Authors Fu Jing, et al.
    Applications Unspecified
    Reactivity
  • Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion
    Year 2026
    Journal Theranostics
    Authors Yi-Fan Zhou, et al.
    Applications Unspecified
    Reactivity
  • Spatial heterogeneity of lactylation: Insights into gene expression, metabolism, and lactate transport in human embryonic stem cells
    Year 2025
    Journal Biology Open
    Authors Kozlov Alexandra M., et al.
    Applications Unspecified
    Reactivity
  • Lactate represses MHC-I antigen presentation via H4K5 lactylation-PRC2 in small cell lung cancer subtype A
    Year 2025
    Journal INTERNATIONAL IMMUNOPHARMACOLOGY
    Authors Yifan Cai, et al.
    Applications Unspecified
    Reactivity
  • HNRNPC lactylation promotes pancreatic cancer progression through mediating the alternative splicing of PAK6
    Year 2025
    Journal CANCER LETTERS
    Authors BoHao Li, et al.
    Applications Unspecified
    Reactivity
  • HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis
    Year 2025
    Journal BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
    Authors Yanan Zhang, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes mRNA translation in colorectal cancer cells through eEF2 lactylation
    Year 2025
    Journal BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    Authors Mohammad Nasiruddin Rana, et al.
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    Reactivity
  • H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2+ Treg recruitment
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    Journal EXPERIMENTAL AND MOLECULAR MEDICINE
    Authors Ye Linlin, et al.
    Applications Unspecified
    Reactivity
  • Identification of lactylation-related biomarkers in HNSC by integrating machine learning and Spatial transcriptomics analysis
    Year 2025
    Journal Discover Oncology
    Authors Wang Pu-Yu, et al.
    Applications Unspecified
    Reactivity
  • Lactate metabolism inhibition disrupts goat oocyte meiosis via H3K18la-mediated epigenetic dysregulation
    Year 2025
    Journal THERIOGENOLOGY
    Authors Dongxu Li, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation is associated with METTL3-dependent LCN2 m6A modification and astrocyte activation after intracerebral hemorrhage
    Year 2025
    Journal NEUROCHEMISTRY INTERNATIONAL
    Authors Ling Gao, et al.
    Applications Unspecified
    Reactivity
  • Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration
    Year 2025
    Journal World Journal of Stem Cells
    Authors Ting Zhang, et al.
    Applications Unspecified
    Reactivity
  • Discovery of potential involvement of protein lactylation during the development of pork quality
    Year 2025
    Journal MEAT SCIENCE
    Authors Chao Ma, et al.
    Applications Unspecified
    Reactivity
  • Bioinformatics Analysis and Experimental Validation of Lactylation Related Genes in Lung Adenocarcinoma
    Year 2025
    Journal Cancer Management and Research
    Authors Li Gao, et al.
    Applications Unspecified
    Reactivity
  • Global Lactylome Reveals Lactylation‐Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome
    Year 2025
    Journal MedComm
    Authors Xu Liu, et al.
    Applications Unspecified
    Reactivity
  • Hypoxia facilitates stemness of colon cancer cells via histone lactylation
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    Authors Qi Zhang, et al.
    Applications Unspecified
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  • ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake
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    Journal CELL BIOLOGY AND TOXICOLOGY
    Authors Liu Yue, et al.
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  • Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics
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    Authors Yanjun Chen, et al.
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  • Matrix stiffness-sensitive LDHA drives autophagy of pancreatic ductal adenocarcinoma via inducing FOXO3 expression and lactylation
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    Authors Tiancheng Gong, et al.
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  • Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling
    Year 2025
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    Authors Xiao Hu, et al.
    Applications Unspecified
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  • Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading
    Year 2025
    Journal Journal of Neuroinflammation
    Authors Liu Xiaoli, et al.
    Applications Unspecified
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  • Lactate regulates cell differentiation of erythroid progenitor cells via histone lactylation modification
    Year 2025
    Journal iScience
    Authors Qianqian Yang, et al.
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  • NCAPD3 contributes to lung cancer progression through modulated lactate-induced histone lactylation and MEK/ERK/LDHA axis
    Year 2025
    Journal Cancer Cell International
    Authors Chang Zhibo
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  • Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways
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    Journal Advanced Science
    Authors Fanju Meng, et al.
    Applications Unspecified
    Reactivity
  • Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury
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    Journal NEURON
    Authors Xuhui Ge, et al.
    Applications Unspecified
    Reactivity
  • Deacetylation of ANXA2 by SIRT2 desensitizes hepatocellular carcinoma cells to donafenib via promoting protective autophagy
    Year 2025
    Journal CELL DEATH AND DIFFERENTIATION
    Authors Sun Liangbo, et al.
    Applications Unspecified
    Reactivity
  • Lactate-induced macrophage HMGB1 lactylation promotes neutrophil extracellular trap formation in sepsis-associated acute kidney injury
    Year 2025
    Journal CELL BIOLOGY AND TOXICOLOGY
    Authors Wei Siwei, et al.
    Applications Unspecified
    Reactivity
  • MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis
    Year 2025
    Journal Advanced Science
    Authors Min Sun, et al.
    Applications Unspecified
    Reactivity
  • Exercise-Mediated Mechanical Stress Promotes Osteogenic Differentiation of BMSCs Through Upregulation of Lactylation via the IER3/LDHB Axis
    Year 2025
    Journal FASEB JOURNAL
    Authors Shuo Dai, et al.
    Applications Unspecified
    Reactivity
  • Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression
    Year 2025
    Journal Journal of Translational Medicine
    Authors Liu Jinlin, et al.
    Applications Unspecified
    Reactivity
  • Protocol to study the genomic profile of histone lactylation with CUT&RUN assay in tumor-associated macrophages
    Year 2025
    Journal STAR Protocols
    Authors Alessandra De Leo, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation regulates early embryonic development through m6A methyltransferase METTL3 in goats
    Year 2025
    Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
    Authors Dongxu Li, et al.
    Applications Unspecified
    Reactivity
  • Glycolysis-Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration
    Year 2025
    Journal Advanced Science
    Authors Kaiqiang Sun, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis
    Year 2025
    Journal Cell Death & Disease
    Authors Deng Jiao, et al.
    Applications Unspecified
    Reactivity
  • G6PD lactylation is involved in regulating redox balance of boar sperm in low glucose extender
    Year 2025
    Journal THERIOGENOLOGY
    Authors Jia Cheng, et al.
    Applications Unspecified
    Reactivity
  • Histone lactylation protects against sevoflurane-induced cognitive impairment by regulating YTHDF3/PRDX3 mediated microglial pyroptosis in neonatal mice
    Year 2025
    Journal INTERNATIONAL IMMUNOPHARMACOLOGY
    Authors Yang Zhang, et al.
    Applications Unspecified
    Reactivity
  • Oxidative stress regulates the catalytic activity and mitochondrial localization of HK2 in trophoblast by regulating K346 lactylation
    Year 2025
    Journal FASEB JOURNAL
    Authors Zhirui Chen, et al.
    Applications Unspecified
    Reactivity
  • Integration of scRNA-seq and bulk RNA-seq to reveal the association and potential molecular mechanisms of metabolic reprogramming regulated by lactylation and chemotherapy resistance in ovarian cancer
    Year 2025
    Journal Frontiers in Immunology
    Authors Fang Ren, et al.
    Applications Unspecified
    Reactivity
  • Metabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop
    Year 2025
    Journal CELL DEATH AND DIFFERENTIATION
    Authors Xiong Junjun, et al.
    Applications Unspecified
    Reactivity
  • Cancer-associated fibroblasts promote EGFR-TKI resistance via the CTHRC1/glycolysis/H3K18la positive feedback loop
    Year 2025
    Journal ONCOGENE
    Authors Zhang Chen, et al.
    Applications Unspecified
    Reactivity
  • HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer
    Year 2025
    Journal Advanced Science
    Authors Xiaoniu He, et al.
    Applications Unspecified
    Reactivity
  • ACAT1-Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production
    Year 2025
    Journal Advanced Science
    Authors Cuimiao Zheng, et al.
    Applications Unspecified
    Reactivity
  • Lactate-triggered histone lactylation contributes to podocyte epithelial-mesenchymal transition in diabetic nephropathy in mice
    Year 2025
    Journal CHEMICO-BIOLOGICAL INTERACTIONS
    Authors Ting Zheng, et al.
    Applications Unspecified
    Reactivity
  • The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii
    Year 2025
    Journal Microbiology Spectrum
    Authors Chenghuan Li, et al.
    Applications Unspecified
    Reactivity
  • Infection-induced lysine lactylation enables herpesvirus immune evasion
    Year 2025
    Journal Science Advances
    Authors Matthew D. Tyl, et al.
    Applications Unspecified
    Reactivity
  • Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice
    Year 2025
    Journal DEVELOPMENTAL CELL
    Authors Zhimin Li, et al.
    Applications Unspecified
    Reactivity
  • Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
    Year 2025
    Journal CELL RESEARCH
    Authors Zhao Qihang, et al.
    Applications Unspecified
    Reactivity
  • Differences in protein lactylation between pale, soft and exudative and red, firm and non-exudative pork
    Year 2024
    Journal MEAT SCIENCE
    Authors Chao Ma, et al.
    Applications Unspecified
    Reactivity
  • Integrating Bulk RNA and Single‐Cell RNA Sequencing Identifies and Validates Lactylation‐Related Signatures for Intervertebral Disc Degeneration
    Year 2024
    Journal JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
    Authors Yangyang Shi, et al.
    Applications Unspecified
    Reactivity
  • NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells
    Year 2024
    Journal Molecular Brain
    Authors Cheng Jing, et al.
    Applications Unspecified
    Reactivity
  • Lactylation of Hdac1 regulated by Ldh prevents the pluripotent-to-2C state conversion
    Year 2024
    Journal Stem Cell Research & Therapy
    Authors Dong Qiman, et al.
    Applications Unspecified
    Reactivity
  • Metabolically inducing defects in DNA repair sensitizes BRCA–wild-type cancer cells to replication stress
    Year 2024
    Journal Science Signaling
    Authors Kenji Watanabe, et al.
    Applications Unspecified
    Reactivity
  • Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption
    Year 2024
    Journal Advanced Science
    Authors Fan Ouyang, et al.
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  • Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication
    Year 2024
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  • Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity
    Year 2024
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    Authors Yewei Huang, et al.
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  • Increased DNMT1 acetylation leads to global DNA methylation suppression in follicular granulosa cells during reproductive aging in mammals
    Year 2024
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    Authors Zhao Shunran, et al.
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  • RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition
    Year 2024
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  • Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway
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    Journal Biomedicines
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  • Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation
    Year 2024
    Journal CELLULAR SIGNALLING
    Authors Jingyi Li, et al.
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  • Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
    Year 2024
    Journal Nature Communications
    Authors Sun Shuangshuang, et al.
    Applications Unspecified
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  • AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
    Year 2024
    Journal NATURE
    Authors Li Heyu, et al.
    Applications Unspecified
    Reactivity
  • Dynamic changes of protein lactylation and their correlations with the glycolytic process during the postmortem acidification of broiler breast
    Year 2024
    Journal POULTRY SCIENCE
    Authors Zhenxin Wang, et al.
    Applications Unspecified
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  • Lactyllysine Esterification Enables Efficient Lactylprotein Expression via Genetic Code Expansion and Supports Functional Proteomics Studies
    Year 2024
    Journal JOURNAL OF PROTEOME RESEARCH
    Authors Dexiang Wang, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes microglial scar formation and facilitates locomotor function recovery by enhancing histone H4 lysine 12 lactylation after spinal cord injury
    Year 2024
    Journal Journal of Neuroinflammation
    Authors Hu Xuyang, et al.
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  • Mitochondrial DNA Programs Lactylation of cGAS to Induce IFN Responses in Patients with Systemic Lupus Erythematosus
    Year 2024
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  • Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation
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  • NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
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  • The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation
    Year 2024
    Journal Journal of Animal Science and Biotechnology
    Authors Wei Yaozong, et al.
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  • Lactate-induced IGF1R protein lactylation promotes proliferation and metabolic reprogramming of lung cancer cells
    Year 2024
    Journal Open Life Sciences
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  • Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation
    Year 2024
    Journal Cell Reports
    Authors Yunjia Zhang, et al.
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  • Histone Lactylation Is Involved in Mouse Oocyte Maturation and Embryo Development
    Year 2024
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Diqi Yang, et al.
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  • ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
    Year 2024
    Journal DIABETOLOGIA
    Authors Chen Jingfang, et al.
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  • Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
    Year 2024
    Journal JOURNAL OF HEPATOLOGY
    Authors Long Yang, et al.
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  • Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
    Year 2024
    Journal CELL
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  • Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
    Year 2024
    Journal ACTA HISTOCHEMICA ET CYTOCHEMICA
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  • Single-embryo transcriptomic atlas of oxygen response reveals the critical role of HIF-1α in prompting embryonic zygotic genome activation
    Year 2024
    Journal Redox Biology
    Authors Fusheng Yao, et al.
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  • Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
    Year 2024
    Journal Molecular Metabolism
    Authors T. Desgeorges, et al.
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  • Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma
    Year 2024
    Journal Cell Death Discovery
    Authors Wei Sitian, et al.
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  • Glycolysis-Stimulated Esrrb Lactylation Promotes the Self-Renewal and Extraembryonic Endoderm Stem Cell Differentiation of Embryonic Stem Cells
    Year 2024
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Qiman Dong, et al.
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  • cGAS Deficiency Regulates the Phenotypic Polarization and Glycolysis of Microglia Through Lactylation in Hypoxic-Ischemic Encephalopathy Cell Model
    Year 2024
    Journal BIOCHEMICAL GENETICS
    Authors Wang Lisheng, et al.
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  • Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9
    Year 2024
    Journal CANCER BIOLOGY & THERAPY
    Authors Fei Yan, et al.
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  • Histone lactylation couples cellular metabolism with developmental gene regulatory networks
    Year 2024
    Journal Nature Communications
    Authors Merkuri Fjodor, et al.
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  • Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages
    Year 2024
    Journal MOLECULES
    Authors Shian Hu, et al.
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  • Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
    Year 2023
    Journal Cell Metabolism
    Authors Hyunsoo Rho, et al.
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  • The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity
    Year 2023
    Journal Cell Metabolism
    Authors Xuedan Sun, et al.
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  • ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation
    Year 2023
    Journal Science Advances
    Authors Mengshu Jia, et al.
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  • High-Intensity Interval Training Induces Protein Lactylation in Different Tissues of Mice with Specificity and Time Dependence
    Year 2023
    Journal Metabolites
    Authors Wenhua Huang, et al.
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  • Lactate dehydrogenase A mediated histone lactylation induced the pyroptosis through targeting HMGB1
    Year 2023
    Journal METABOLIC BRAIN DISEASE
    Authors Yao Xuan, et al.
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    Journal DEVELOPMENTAL CELL
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  • Progesterone activates histone lactylation-Hif1α-glycolysis feedback loop to promote decidualization
    Year 2023
    Journal ENDOCRINOLOGY
    Authors Zhao Wei, et al.
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  • Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis
    Year 2023
    Journal Clinical Epigenetics
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  • Dynamic patterns of histone lactylation during early tooth development in mice
    Year 2023
    Journal JOURNAL OF MOLECULAR HISTOLOGY
    Authors Liu Ming, et al.
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  • Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation
    Year 2023
    Journal Frontiers in Physiology
    Authors Madison L. Mattingly, et al.
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    Year 2023
    Journal BMC BIOLOGY
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    Year 2023
    Journal Journal of Neuroinflammation
    Authors Wei Lin, et al.
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  • α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
    Year 2023
    Journal CELL RESEARCH
    Authors Zhang Naijin, et al.
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  • Lactate induces tumor-associated macrophage polarization independent of mitochondrial pyruvate carrier-mediated metabolism
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    Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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    Year 2023
    Journal Cell Reports
    Authors He Y, et al.
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    Year 2022
    Journal Cell Metabolism
    Authors Rui-Yuan Pan, et al.
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  • ULK1-Mediated Metabolic Reprogramming Regulates Vps34 Lipid Kinase Activity by Its Lactylation
    Year 2022
    Journal MOLECULAR CELL
    Authors Yue Xiao, et al.
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    Year 2022
    Journal MOLECULAR CELL
    Authors Jia Xiong, et al.
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  • H3K18 lactylation marks tissue-specific active enhancers
    Year 2022
    Journal GENOME BIOLOGY
    Authors Galle Eva, et al.
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  • Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease
    Year 2022
    Journal JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
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    Year 2022
    Journal Science Advances
    Authors Carlos Moreno-Yruela, et al.
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    Journal PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    Authors Quan Liu, et al.
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    Year 2022
    Journal Cell Reports
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    Year 2022
    Journal BRITISH JOURNAL OF CANCER
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    Year 2022
    Journal ONCOGENE
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    Journal Frontiers in Nutrition
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    Journal GENOMICS PROTEOMICS & BIOINFORMATICS
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  • Single-Embryo Transcriptomic Atlas of Oxygen Response Reveals the Critical Role of HIF-1α in Prompting Major Zygotic Gene Activation
    Year 2022
    Journal iScience
    Authors Yao Fusheng, et al.
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  • Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia
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    Journal JOURNAL OF HYPERTENSION
    Authors Li Xiang, et al.
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    Year 2022
    Journal BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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  • Effect of lactylation on functional and structural properties of gluten.
    Year 2022
    Journal Frontiers in Nutrition
    Authors Yu Wang, et al.
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  • Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE
    Year 2021
    Journal CELL
    Authors Simone Caielli, et al.
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  • Lactate and IL6 define separable paths of inflammatory metabolic adaptation
    Year 2021
    Journal Science Advances
    Authors Stefanie Dichtl, et al.
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  • Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma
    Year 2021
    Journal GENOME BIOLOGY
    Authors Yu Jie, et al.
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  • Protein lactylation induced by neural excitation
    Year 2021
    Journal Cell Reports
    Authors Hideo Hagihara, et al.
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  • Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota.
    Year 2021
    Journal Frontiers in Immunology
    Authors Sun S, et al.
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  • Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation
    Year 2021
    Journal AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
    Authors Huachun Cui, et al.
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  • Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer
    Year 2021
    Journal Frontiers in Oncology
    Authors Jiang Jun, et al.
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  • Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains
    Year 2021
    Journal JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
    Authors Xiaoxi Meng, et al.
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  • Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice
    Year 2021
    Journal Epigenetics & Chromatin
    Authors Yang Wanting, et al.
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  • Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota
    Year 2021
    Journal Frontiers in Immunology
    Authors Sun Siyuan, et al.
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  • Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
    Year 2020
    Journal Nature Metabolism
    Authors Li Linpeng, et al.
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  • TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation
    Year 2020
    Journal PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    Authors Ricardo A. Irizarry-Caro, et al.
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    Year 2020
    Journal ENDOCRINOLOGY
    Authors Li Yinchuan, et al.
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  • Metabolic regulation of gene expression by histone lactylation
    Year 2019
    Journal NATURE
    Authors Zhang Di, et al.
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