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Recombinant Rabbit Monoclonal
Anti-L-Lactyllysine Rabbit pAb
Catalog Number: PTM-1401
References (152)
$ 435

Clone Number: /

Host: Rabbit Clonality: Polyclonal

Applications： WB FC

Reactivity: All

Synonyms: Kla, L-la

Product Size
100μl

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms Kla, L-la
UniProt ID

/

Immunogen L-lactylated lysine peptides
MW (kDa) Multiple
Specificity Anti-L-Lactyllysine Rabbit pAb detects proteins with L-lactylated lysine residues. This pan antibody recognizes L-lactylated lysine independent of its surrounding sequences.
Product Usage Information
Applications Dilution Recommended Species
WB 1:500 - 1:1000 All
FC 1:50 Human
Properties
Purity Protein A and immunogen affinity purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

Lactate, previously recognized solely as an energy source and metabolic byproduct, has now emerged as a crucial player in cancer biology, especially within the scope of the Warburg effect and its intricate interplay with various cellular processes, including angiogenesis, hypoxia, polarization of macrophages, and T cell activation. Recent investigations have unveiled an unprecedented function of lactate in the realm of histone modification, specifically through lysine L-lactylation, which exerts regulatory control over gene expression. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The acetyltransferase p300 is responsible for introducing lysine L-lactylation, while Class I histone deacetylases (HDAC 1-3) have been identified as an eraser of the lactylation marks on histones. Although initially identified on histone proteins, L-lactylation has since been detected on a broad range of non-histone substrates. Among the known isomers, including D-lactylation and N-ε-carboxyethylation, L-lactylation is the predominant form found in cells and the major participant in glycolysis and the Warburg effect.

Cellular location

/

Images
Dot Blot

Peptide amount: 4 ng, 20 ng, 100 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:2000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
The list of peptides used in the experiment is provided in the table below:
WB

Lysates: (-) HeLa cells; (+) HeLa cells treated with 100 mM sodium lactate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: Mouse kidney, mouse spleen
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: HeLa, N2a, BRL
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)
Exposure time: 30 seconds
Predicted band size: Multiple
Observed band size: Multiple
FC

Sample: HeLa cells
Fixative: 4% Paraformaldehyde
Permeabilization: 0.1% Triton X-100
Primary Ab dilution: 1:50
Secondary Ab: Goat Anti-Rabbit IgG
Unlabeled control: The cell without incubation with primary antibody and secondary antibody (black line).
Isotype control: Rabbit mAb IgG Isotype Control (blue line).
Description: The red line represents the positive signal observed with PTM-1401.

Research Use

For research use only, not for use in diagnostic procedures.

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References (152)
  • Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease
    Year 2026
    Journal Int J Biol Sci
    Authors Shen Siman, et al.
    Applications WB
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  • Histone H3K9 Lactylation Activates the TXNIP/NLRP3 Pathway to Drive Macrophage Inflammation after Spinal Cord Injury
    Year 2026
    Journal Redox Biol
    Authors Chaoran Shi, et al.
    Applications WB, IF
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  • Histone H4 lysine 5 lactylation: A key regulator of immune metabolism in microglia during ischemic stroke
    Year 2026
    Journal Pharmacol Res
    Authors Yishan Li, et al.
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  • HSPA8 lactylation attenuates neuronal pyroptosis via E3 ligase-mediated NLRP3 degradation after ischemic stroke
    Year 2026
    Journal Apoptosis
    Authors Fu Jing, et al.
    Applications Unspecified
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  • Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension
    Year 2026
    Journal Int J Mol Sci
    Authors Xingbing Li, et al.
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  • Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion
    Year 2026
    Journal Theranostics
    Authors Yi-Fan Zhou, et al.
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  • NAA20-mediated ACF1 lactylation drives neuroblastoma progression through enhancing GCLM-dependent glutathione synthesis
    Year 2026
    Journal Cell Biol Toxicol
    Authors Bingqiang Han, et al.
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  • Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells
    Year 2026
    Journal Front Cell Infect Microbiol
    Authors Qinrui Wu, et al.
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  • ALYREF promotes laryngeal cancer progression through a lactate-mediated lactylation feedback loop that enhances glycolysis
    Year 2026
    Journal Tumori
    Authors Shanyan Bian, et al.
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  • Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication
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    Journal Adv Sci (Weinh)
    Authors Pengjun Wei, et al.
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  • Lactylation omics of rabbit rotator cuff tear reveals differentially modified proteins and metabolic relating therapy targets
    Year 2026
    Journal Front Med (Lausanne)
    Authors Tong Pan & Zhenlong Liu
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  • Helicobacter pylori activates histone lactylation to promote gastric cancer progression and immune evasion through the HAS2/c-MYC/PD-L1 axis
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  • Histone delactylation shapes epigenetic landscapes and therapeutic stratification in hepatocellular carcinoma
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    Journal Iliver
    Authors Zijie Wu, et al.
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  • HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription
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    Authors Xiaoxuan Zhao, et al.
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  • Histone lactylation modulates apoptosis and stress response through PI3K/AKT signaling in GC-1 spermatogonial cells under hypoxia
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    Journal Rev Int Androl
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  • Exosomes derived from human umbilical cord mesenchymal stem cells attenuate neuroinflammation in intracerebral hemorrhage rats by modulating lactylation modification
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    Journal J Transl Med
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  • ACAT1-Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production
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  • Bioinformatics Analysis and Experimental Validation of Lactylation Related Genes in Lung Adenocarcinoma
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    Journal Cancer Manag Res
    Authors Li Gao, et al.
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  • Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration
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    Authors Ting Zhang, et al.
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    Journal Oncogene
    Authors Zhang Chen, et al.
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    Authors Ling Gao, et al.
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    Journal Int Immunopharmacol
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    Journal Int J Biol Macromol
    Authors Dongxu Li, et al.
    Applications Unspecified
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    Authors Yanan Zhang, et al.
    Applications Unspecified
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  • HNRNPC lactylation promotes pancreatic cancer progression through mediating the alternative splicing of PAK6
    Year 2025
    Journal Cancer Lett
    Authors BoHao Li, et al.
    Applications Unspecified
    Reactivity
  • Hypoxia facilitates stemness of colon cancer cells via histone lactylation
    Year 2025
    Journal Biochim Biophys Acta Mol Basis Dis
    Authors Qi Zhang, et al.
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  • Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics
    Year 2025
    Journal Front Immunol
    Authors Yanjun Chen, et al.
    Applications WB
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  • Identification of lactylation-related biomarkers in HNSC by integrating machine learning and Spatial transcriptomics analysis
    Year 2025
    Journal Discov Oncol
    Authors Wang Pu-Yu, et al.
    Applications WB
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  • Infection-induced lysine lactylation enables herpesvirus immune evasion
    Year 2025
    Journal Sci Adv
    Authors Matthew D. Tyl, et al.
    Applications Unspecified
    Reactivity
  • Integration of scRNA-seq and bulk RNA-seq to reveal the association and potential molecular mechanisms of metabolic reprogramming regulated by lactylation and chemotherapy resistance in ovarian cancer
    Year 2025
    Journal Front Immunol
    Authors Fang Ren, et al.
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  • Lactate metabolism inhibition disrupts goat oocyte meiosis via H3K18la-mediated epigenetic dysregulation
    Year 2025
    Journal Theriogenology
    Authors Dongxu Li, et al.
    Applications Unspecified
    Reactivity
  • Lactate promotes mRNA translation in colorectal cancer cells through eEF2 lactylation
    Year 2025
    Journal Biochem Biophys Res Commun
    Authors Mohammad Nasiruddin Rana, et al.
    Applications Unspecified
    Reactivity
  • Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling
    Year 2025
    Journal Cell Prolif
    Authors Xiao Hu, et al.
    Applications Unspecified
    Reactivity
  • Lactate regulates cell differentiation of erythroid progenitor cells via histone lactylation modification
    Year 2025
    Journal iScience
    Authors Qianqian Yang, et al.
    Applications Unspecified
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  • Lactate represses MHC-I antigen presentation via H4K5 lactylation-PRC2 in small cell lung cancer subtype A
    Year 2025
    Journal Int Immunopharmacol
    Authors Yifan Cai, et al.
    Applications Unspecified
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  • Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice
    Year 2025
    Journal Dev Cell
    Authors Zhimin Li, et al.
    Applications Unspecified
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    Year 2025
    Journal Cell Biol Toxicol
    Authors Wei Siwei, et al.
    Applications Unspecified
    Reactivity
  • Lactate-triggered histone lactylation contributes to podocyte epithelial-mesenchymal transition in diabetic nephropathy in mice
    Year 2025
    Journal Chem Biol Interact
    Authors Ting Zheng, et al.
    Applications Unspecified
    Reactivity
  • Matrix stiffness-sensitive LDHA drives autophagy of pancreatic ductal adenocarcinoma via inducing FOXO3 expression and lactylation
    Year 2025
    Journal Biomater Adv
    Authors Tiancheng Gong, et al.
    Applications Unspecified
    Reactivity
  • MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis
    Year 2025
    Journal Adv Sci (Weinh)
    Authors Min Sun, et al.
    Applications Unspecified
    Reactivity
  • Metabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop
    Year 2025
    Journal Cell Death Differ
    Authors Xiong Junjun, et al.
    Applications Unspecified
    Reactivity
  • Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury
    Year 2025
    Journal Neuron
    Authors Xuhui Ge, et al.
    Applications Unspecified
    Reactivity
  • NCAPD3 contributes to lung cancer progression through modulated lactate-induced histone lactylation and MEK/ERK/LDHA axis
    Year 2025
    Journal Cancer Cell Int
    Authors Chang Zhibo
    Applications Unspecified
    Reactivity
  • Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
    Year 2025
    Journal Cell Res
    Authors Zhao Qihang, et al.
    Applications Unspecified
    Reactivity
  • Oxidative stress regulates the catalytic activity and mitochondrial localization of HK2 in trophoblast by regulating K346 lactylation
    Year 2025
    Journal FASEB J
    Authors Zhirui Chen, et al.
    Applications Unspecified
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  • Protocol to study the genomic profile of histone lactylation with CUT&RUN assay in tumor-associated macrophages
    Year 2025
    Journal STAR Protoc
    Authors Alessandra De Leo, et al.
    Applications Unspecified
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  • Spatial heterogeneity of lactylation: Insights into gene expression, metabolism, and lactate transport in human embryonic stem cells
    Year 2025
    Journal Biol Open
    Authors Kozlov Alexandra M., et al.
    Applications Unspecified
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  • The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii
    Year 2025
    Journal Microbiol Spectr
    Authors Chenghuan Li, et al.
    Applications WB
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  • ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake
    Year 2025
    Journal Cell Biol Toxicol
    Authors Liu Yue, et al.
    Applications Unspecified
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  • Histone lactylation-driven B7-H3 expression promotes tumor immune evasion
    Year 2025
    Journal Theranostics
    Authors Zhibo Ma, et al.
    Applications WB
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  • CAFs promote immune evasion in gastric cancer through histone lactylation-mediated suppression of NCAPG ubiquitination
    Year 2025
    Journal J Transl Med
    Authors Sheng Zhou, et al.
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  • Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism
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    Journal Cancer Biol Ther
    Authors Zhuo Li, et al.
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  • Dynamic investigation of hypoxia- induced L- lactylation
    Year 2025
    Journal Proc Natl Acad Sci U S A
    Authors Jinjun Gao, et al.
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  • AARS1-mediated Osterix lactylation promotes its transcriptional activity during osteoblast differentiation
    Year 2025
    Journal Acta Histochem
    Authors Feige Nian, et al.
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  • AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
    Year 2024
    Journal Nature
    Authors Li Heyu, et al.
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  • ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
    Year 2024
    Journal Diabetologia
    Authors Chen Jingfang, et al.
    Applications Unspecified
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  • Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
    Year 2024
    Journal Cell
    Authors Zhi Zong, et al.
    Applications Unspecified
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  • Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption
    Year 2024
    Journal Adv Sci (Weinh)
    Authors Fan Ouyang, et al.
    Applications Unspecified
    Reactivity
  • Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation
    Year 2024
    Journal Theranostics
    Authors Xiao-Yi Xiong, et al.
    Applications WB, IF, IAP
    Reactivity
  • cGAS Deficiency Regulates the Phenotypic Polarization and Glycolysis of Microglia Through Lactylation in Hypoxic-Ischemic Encephalopathy Cell Model
    Year 2024
    Journal Biochem Genet
    Authors Wang Lisheng, et al.
    Applications Unspecified
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  • Differences in protein lactylation between pale, soft and exudative and red, firm and non-exudative pork
    Year 2024
    Journal Meat Sci
    Authors Chao Ma, et al.
    Applications Unspecified
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  • Dynamic changes of protein lactylation and their correlations with the glycolytic process during the postmortem acidification of broiler breast
    Year 2024
    Journal Poult Sci
    Authors Zhenxin Wang, et al.
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  • Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation
    Year 2024
    Journal Tissue Cell
    Authors Zhen-Peng Xu, et al.
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  • Glycolysis-Stimulated Esrrb Lactylation Promotes the Self-Renewal and Extraembryonic Endoderm Stem Cell Differentiation of Embryonic Stem Cells
    Year 2024
    Journal Int J Mol Sci
    Authors Qiman Dong, et al.
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  • H3K18 lactylation accelerates liver fibrosis progression through facilitating SOX9 transcription
    Year 2024
    Journal Exp Cell Res
    Authors Shujun Wu, et al.
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  • Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation
    Year 2024
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    Year 2024
    Journal Nat Commun
    Authors Merkuri Fjodor, et al.
    Applications Unspecified
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  • Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
    Year 2024
    Journal Mol Metab
    Authors T. Desgeorges, et al.
    Applications WB
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  • Histone Lactylation Is Involved in Mouse Oocyte Maturation and Embryo Development
    Year 2024
    Journal Int J Mol Sci
    Authors Diqi Yang, et al.
    Applications Unspecified
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  • Hypoxia exposure induces lactylation of Axin1 protein to promote glycolysis of esophageal carcinoma cells
    Year 2024
    Journal Biochem Pharmacol
    Authors Qian Li, et al.
    Applications Unspecified
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  • Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9
    Year 2024
    Journal Cancer Biol Ther
    Authors Fei Yan, et al.
    Applications Unspecified
    Reactivity
  • Increased DNMT1 acetylation leads to global DNA methylation suppression in follicular granulosa cells during reproductive aging in mammals
    Year 2024
    Journal BMC Genomics
    Authors Zhao Shunran, et al.
    Applications Unspecified
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  • Integrating Bulk RNA and Single‐Cell RNA Sequencing Identifies and Validates Lactylation‐Related Signatures for Intervertebral Disc Degeneration
    Year 2024
    Journal J Cell Mol Med
    Authors Yangyang Shi, et al.
    Applications WB, ICC/IF
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  • Lactate promotes microglial scar formation and facilitates locomotor function recovery by enhancing histone H4 lysine 12 lactylation after spinal cord injury
    Year 2024
    Journal J Neuroinflammation
    Authors Hu Xuyang, et al.
    Applications WB, IF
    Reactivity
  • Lactate-induced IGF1R protein lactylation promotes proliferation and metabolic reprogramming of lung cancer cells
    Year 2024
    Journal Open Life Sci
    Authors Rong Zhang, et al.
    Applications Unspecified
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  • Lactylation of Hdac1 regulated by Ldh prevents the pluripotent-to-2C state conversion
    Year 2024
    Journal Stem Cell Res Ther
    Authors Dong Qiman, et al.
    Applications WB
    Reactivity
  • Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity
    Year 2024
    Journal J Cell Biol
    Authors Yewei Huang, et al.
    Applications Unspecified
    Reactivity
  • Lactyllysine Esterification Enables Efficient Lactylprotein Expression via Genetic Code Expansion and Supports Functional Proteomics Studies
    Year 2024
    Journal J Proteome Res
    Authors Dexiang Wang, et al.
    Applications Unspecified
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  • Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation
    Year 2024
    Journal Cell Rep
    Authors Yunjia Zhang, et al.
    Applications Unspecified
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  • Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
    Year 2024
    Journal Nat Commun
    Authors Sun Shuangshuang, et al.
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  • Metabolically inducing defects in DNA repair sensitizes BRCA–wild-type cancer cells to replication stress
    Year 2024
    Journal Sci Signal
    Authors Kenji Watanabe, et al.
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  • Mitochondrial DNA Programs Lactylation of cGAS to Induce IFN Responses in Patients with Systemic Lupus Erythematosus
    Year 2024
    Journal J Immunol
    Authors Zhang Juan, et al.
    Applications Unspecified
    Reactivity
  • NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
    Year 2024
    Journal Nature
    Authors Chen Hengxing, et al.
    Applications Unspecified
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  • NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells
    Year 2024
    Journal Mol Brain
    Authors Cheng Jing, et al.
    Applications Unspecified
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  • Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
    Year 2024
    Journal J Hepatol
    Authors Long Yang, et al.
    Applications Unspecified
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  • Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway
    Year 2024
    Journal Biomedicines
    Authors Lu He, et al.
    Applications Unspecified
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  • Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
    Year 2024
    Journal Acta Histochem Cytochem
    Authors Tomoki Takata, et al.
    Applications Unspecified
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  • RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition
    Year 2024
    Journal Cancer Metab
    Authors Zhao Rui, et al.
    Applications Unspecified
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  • Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages
    Year 2024
    Journal Molecules
    Authors Shian Hu, et al.
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  • Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication
    Year 2024
    Journal EMBO Rep
    Authors LiuBingxin , et al.
    Applications Unspecified
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  • Single-embryo transcriptomic atlas of oxygen response reveals the critical role of HIF-1α in prompting embryonic zygotic genome activation
    Year 2024
    Journal Redox Biol
    Authors Fusheng Yao, et al.
    Applications Unspecified
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  • The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation
    Year 2024
    Journal J Anim Sci Biotechnol
    Authors Wei Yaozong, et al.
    Applications ICC/IF
    Reactivity
  • Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells
    Year 2024
    Journal iScience
    Authors Zhe Cheng
    Applications WB, IAP
    Reactivity
  • BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development
    Year 2023
    Journal Dev Cell
    Authors Yanyan Wang, et al.
    Applications Unspecified
    Reactivity
  • Dynamic patterns of histone lactylation during early tooth development in mice
    Year 2023
    Journal J Mol Histol
    Authors Liu Ming, et al.
    Applications Unspecified
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  • H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
    Year 2023
    Journal J Neuroinflammation
    Authors Wei Lin, et al.
    Applications mIHC
    Reactivity
  • Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis
    Year 2023
    Journal Clin Epigenetics
    Authors Yin Xiangjun, et al.
    Applications Unspecified
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  • Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
    Year 2023
    Journal Cell Metab
    Authors Hyunsoo Rho, et al.
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  • High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis
    Year 2023
    Journal BMC Biol
    Authors Chen Xuefei, et al.
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  • High-Intensity Interval Training Induces Protein Lactylation in Different Tissues of Mice with Specificity and Time Dependence
    Year 2023
    Journal Metabolites
    Authors Wenhua Huang, et al.
    Applications WB
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  • Lactate dehydrogenase A mediated histone lactylation induced the pyroptosis through targeting HMGB1
    Year 2023
    Journal Metab Brain Dis
    Authors Yao Xuan, et al.
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  • Lactate induces tumor-associated macrophage polarization independent of mitochondrial pyruvate carrier-mediated metabolism
    Year 2023
    Journal Int J Biol Macromol
    Authors Xia Fang, et al.
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  • Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation.
    Year 2023
    Journal Cell Rep
    Authors He Y, et al.
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  • Progesterone activates histone lactylation-Hif1α-glycolysis feedback loop to promote decidualization
    Year 2023
    Journal Endocrinology
    Authors Zhao Wei, et al.
    Applications WB, ICC/IF
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  • Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation
    Year 2023
    Journal Front Physiol
    Authors Madison L. Mattingly, et al.
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  • The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity
    Year 2023
    Journal Cell Metab
    Authors Xuedan Sun, et al.
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  • ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation
    Year 2023
    Journal Sci Adv
    Authors Mengshu Jia, et al.
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  • α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
    Year 2023
    Journal Cell Res
    Authors Zhang Naijin, et al.
    Applications Unspecified
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  • Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production
    Year 2022
    Journal Br J Cancer
    Authors Blaszczak Wiktoria, et al.
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  • Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
    Year 2022
    Journal Sci Adv
    Authors Carlos Moreno-Yruela, et al.
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  • Effect of lactylation on functional and structural properties of gluten
    Year 2022
    Journal Front Nutr
    Authors Yu Wang, et al.
    Applications WB
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  • H3K18 lactylation marks tissue-specific active enhancers
    Year 2022
    Journal Genome Biol
    Authors Galle Eva, et al.
    Applications WB
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  • Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia
    Year 2022
    Journal J Hypertens
    Authors Li Xiang, et al.
    Applications Unspecified
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  • Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
    Year 2022
    Journal Mol Cell
    Authors Jia Xiong, et al.
    Applications Unspecified
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  • LDHA promotes osteoblast differentiation through histone lactylation
    Year 2022
    Journal Biochem Biophys Res Commun
    Authors Feige Nian, et al.
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  • Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease
    Year 2022
    Journal J Am Soc Nephrol
    Authors Dang Lin, et al.
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  • Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease
    Year 2022
    Journal Cell Metab
    Authors Rui-Yuan Pan, et al.
    Applications WB
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  • Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii
    Year 2022
    Journal Genomics Proteomics Bioinformatics
    Authors Deqi Yin, et al.
    Applications WB, IF, IP
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  • Single-Embryo Transcriptomic Atlas of Oxygen Response Reveals the Critical Role of HIF-1α in Prompting Major Zygotic Gene Activation
    Year 2022
    Journal iScience
    Authors Yao Fusheng, et al.
    Applications Unspecified
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  • The global succinylation of SARS-CoV-2–infected host cells reveals drug targets
    Year 2022
    Journal Proc Natl Acad Sci U S A
    Authors Quan Liu, et al.
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  • Transgenic construction and functional miRNA analysis identify the role of miR-7 in prostate cancer suppression
    Year 2022
    Journal Oncogene
    Authors Wang Can, et al.
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  • ULK1-Mediated Metabolic Reprogramming Regulates Vps34 Lipid Kinase Activity by Its Lactylation
    Year 2022
    Journal Mol Cell
    Authors Yue Xiao, et al.
    Applications Unspecified
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  • YY1 Lactylation in Microglia Promotes Angiogenesis Through Transcription Activation-Mediated Upregulation of FGF2
    Year 2022
    Journal Cell Rep
    Authors Wang Xiaotang, et al.
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  • Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells
    Year 2022
    Journal EMBO Rep
    Authors Aleksandra Lopez Krol, et al.
    Applications WB
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  • Mechanical Force Modulates Alveolar Bone Marrow Mesenchymal Cells Characteristics for Bone Remodeling during Orthodontic Tooth Movement through Lactate Production
    Year 2022
    Journal Cells
    Authors Mingrui Zhai, et al.
    Applications WB, IHC-P
    Reactivity
  • Lactate-derived HDAC6 Lactylation as a new target for neuronal protection in cerebral ischemic reperfusion injury
    Year 2022
    Journal bioRxiv
    Authors Jun Cao, et al.
    Applications IF
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  • Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains
    Year 2021
    Journal J Agric Food Chem
    Authors Xiaoxi Meng, et al.
    Applications Unspecified
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  • Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE
    Year 2021
    Journal Cell
    Authors Simone Caielli, et al.
    Applications Unspecified
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  • Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma
    Year 2021
    Journal Genome Biol
    Authors Yu Jie, et al.
    Applications Unspecified
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  • Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice
    Year 2021
    Journal Epigenetics Chromatin
    Authors Yang Wanting, et al.
    Applications Unspecified
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  • Lactate and IL6 define separable paths of inflammatory metabolic adaptation
    Year 2021
    Journal Sci Adv
    Authors Stefanie Dichtl, et al.
    Applications Unspecified
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  • Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer
    Year 2021
    Journal Front Oncol
    Authors Jiang Jun, et al.
    Applications Unspecified
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  • Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota
    Year 2021
    Journal Front Immunol
    Authors Sun Siyuan, et al.
    Applications Unspecified
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  • Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation
    Year 2021
    Journal Am J Respir Cell Mol Biol
    Authors Huachun Cui, et al.
    Applications Unspecified
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  • Protein lactylation induced by neural excitation
    Year 2021
    Journal Cell Rep
    Authors Hideo Hagihara, et al.
    Applications Unspecified
    Reactivity
  • Dynamic Profiles and Transcriptional Preferences of Histone Modifications During Spermiogenesis
    Year 2020
    Journal Endocrinology
    Authors Li Yinchuan, et al.
    Applications Unspecified
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  • Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
    Year 2020
    Journal Nat Metab
    Authors Li Linpeng, et al.
    Applications Unspecified
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  • TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation
    Year 2020
    Journal Proc Natl Acad Sci U S A
    Authors Ricardo A. Irizarry-Caro, et al.
    Applications Unspecified
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  • Metabolic regulation of gene expression by histone lactylation
    Year 2019
    Journal Nature
    Authors Zhang Di, et al.
    Applications Unspecified
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