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Differences in protein lactylation between pale, soft and exudative and red, firm and non-exudative pork
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Year
2024
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Journal
MEAT SCIENCE
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Authors
Chao Ma, et al.
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Applications
Unspecified
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Reactivity
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Integrating Bulk RNA and Single‐Cell RNA Sequencing Identifies and Validates Lactylation‐Related Signatures for Intervertebral Disc Degeneration
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Year
2024
-
Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
-
Authors
Yangyang Shi, et al.
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Applications
Unspecified
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Reactivity
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NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells
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Year
2024
-
Journal
Molecular Brain
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Authors
Cheng Jing, et al.
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Applications
Unspecified
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Reactivity
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Lactylation of Hdac1 regulated by Ldh prevents the pluripotent-to-2C state conversion
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Year
2024
-
Journal
Stem Cell Research & Therapy
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Authors
Dong Qiman, et al.
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Applications
Unspecified
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Reactivity
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Metabolically inducing defects in DNA repair sensitizes BRCA–wild-type cancer cells to replication stress
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Year
2024
-
Journal
Science Signaling
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Authors
Kenji Watanabe, et al.
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Applications
Unspecified
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Reactivity
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Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption
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Year
2024
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Journal
Advanced Science
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Authors
Fan Ouyang, et al.
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Applications
Unspecified
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Reactivity
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Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication
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Year
2024
-
Journal
EMBO REPORTS
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Authors
LiuBingxin , et al.
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Applications
Unspecified
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Reactivity
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Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity
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Year
2024
-
Journal
JOURNAL OF CELL BIOLOGY
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Authors
Yewei Huang, et al.
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Applications
Unspecified
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Reactivity
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Increased DNMT1 acetylation leads to global DNA methylation suppression in follicular granulosa cells during reproductive aging in mammals
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Year
2024
-
Journal
BMC GENOMICS
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Authors
Zhao Shunran, et al.
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Applications
Unspecified
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Reactivity
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RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition
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Year
2024
-
Journal
Cancer & Metabolism
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Authors
Zhao Rui, et al.
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Applications
Unspecified
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Reactivity
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Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway
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Year
2024
-
Journal
Biomedicines
-
Authors
Lu He, et al.
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Applications
Unspecified
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Reactivity
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Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation
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Year
2024
-
Journal
CELLULAR SIGNALLING
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Authors
Jingyi Li, et al.
-
Applications
Unspecified
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Reactivity
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Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
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Year
2024
-
Journal
Nature Communications
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Authors
Sun Shuangshuang, et al.
-
Applications
Unspecified
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Reactivity
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AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
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Year
2024
-
Journal
NATURE
-
Authors
Li Heyu, et al.
-
Applications
Unspecified
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Reactivity
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Dynamic changes of protein lactylation and their correlations with the glycolytic process during the postmortem acidification of broiler breast
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Year
2024
-
Journal
POULTRY SCIENCE
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Authors
Zhenxin Wang, et al.
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Applications
Unspecified
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Reactivity
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Lactyllysine Esterification Enables Efficient Lactylprotein Expression via Genetic Code Expansion and Supports Functional Proteomics Studies
-
Year
2024
-
Journal
JOURNAL OF PROTEOME RESEARCH
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Authors
Dexiang Wang, et al.
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Applications
Unspecified
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Reactivity
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Lactate promotes microglial scar formation and facilitates locomotor function recovery by enhancing histone H4 lysine 12 lactylation after spinal cord injury
-
Year
2024
-
Journal
Journal of Neuroinflammation
-
Authors
Hu Xuyang, et al.
-
Applications
Unspecified
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Reactivity
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Mitochondrial DNA Programs Lactylation of cGAS to Induce IFN Responses in Patients with Systemic Lupus Erythematosus
-
Year
2024
-
Journal
JOURNAL OF IMMUNOLOGY
-
Authors
Zhang Juan, et al.
-
Applications
Unspecified
-
Reactivity
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Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation
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Year
2024
-
Journal
TISSUE & CELL
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Authors
Zhen-Peng Xu, et al.
-
Applications
Unspecified
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Reactivity
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Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation
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Year
2024
-
Journal
Theranostics
-
Authors
Xiao-Yi Xiong, et al.
-
Applications
Unspecified
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Reactivity
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Hypoxia exposure induces lactylation of Axin1 protein to promote glycolysis of esophageal carcinoma cells
-
Year
2024
-
Journal
BIOCHEMICAL PHARMACOLOGY
-
Authors
Qian Li, et al.
-
Applications
Unspecified
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Reactivity
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NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
-
Year
2024
-
Journal
NATURE
-
Authors
Chen Hengxing, et al.
-
Applications
Unspecified
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Reactivity
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H3K18 lactylation accelerates liver fibrosis progression through facilitating SOX9 transcription
-
Year
2024
-
Journal
EXPERIMENTAL CELL RESEARCH
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Authors
Shujun Wu, et al.
-
Applications
Unspecified
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Reactivity
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The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation
-
Year
2024
-
Journal
Journal of Animal Science and Biotechnology
-
Authors
Wei Yaozong, et al.
-
Applications
Unspecified
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Reactivity
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Lactate-induced IGF1R protein lactylation promotes proliferation and metabolic reprogramming of lung cancer cells
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Year
2024
-
Journal
Open Life Sciences
-
Authors
Rong Zhang, et al.
-
Applications
Unspecified
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Reactivity
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Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation
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Year
2024
-
Journal
Cell Reports
-
Authors
Yunjia Zhang, et al.
-
Applications
Unspecified
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Reactivity
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Histone Lactylation Is Involved in Mouse Oocyte Maturation and Embryo Development
-
Year
2024
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
-
Authors
Diqi Yang, et al.
-
Applications
Unspecified
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Reactivity
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ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
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Year
2024
-
Journal
DIABETOLOGIA
-
Authors
Chen Jingfang, et al.
-
Applications
Unspecified
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Reactivity
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Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
-
Year
2024
-
Journal
JOURNAL OF HEPATOLOGY
-
Authors
Long Yang, et al.
-
Applications
Unspecified
-
Reactivity
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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
-
Year
2024
-
Journal
CELL
-
Authors
Zhi Zong, et al.
-
Applications
Unspecified
-
Reactivity
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Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
-
Year
2024
-
Journal
ACTA HISTOCHEMICA ET CYTOCHEMICA
-
Authors
Tomoki Takata, et al.
-
Applications
Unspecified
-
Reactivity
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Single-embryo transcriptomic atlas of oxygen response reveals the critical role of HIF-1α in prompting embryonic zygotic genome activation
-
Year
2024
-
Journal
Redox Biology
-
Authors
Fusheng Yao, et al.
-
Applications
Unspecified
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Reactivity
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Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
-
Year
2024
-
Journal
Molecular Metabolism
-
Authors
T. Desgeorges, et al.
-
Applications
Unspecified
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Reactivity
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Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma
-
Year
2024
-
Journal
Cell Death Discovery
-
Authors
Wei Sitian, et al.
-
Applications
Unspecified
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Reactivity
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Glycolysis-Stimulated Esrrb Lactylation Promotes the Self-Renewal and Extraembryonic Endoderm Stem Cell Differentiation of Embryonic Stem Cells
-
Year
2024
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
-
Authors
Qiman Dong, et al.
-
Applications
Unspecified
-
Reactivity
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cGAS Deficiency Regulates the Phenotypic Polarization and Glycolysis of Microglia Through Lactylation in Hypoxic-Ischemic Encephalopathy Cell Model
-
Year
2024
-
Journal
BIOCHEMICAL GENETICS
-
Authors
Wang Lisheng, et al.
-
Applications
Unspecified
-
Reactivity
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Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9
-
Year
2024
-
Journal
CANCER BIOLOGY & THERAPY
-
Authors
Fei Yan, et al.
-
Applications
Unspecified
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Reactivity
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Histone lactylation couples cellular metabolism with developmental gene regulatory networks
-
Year
2024
-
Journal
Nature Communications
-
Authors
Merkuri Fjodor, et al.
-
Applications
Unspecified
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Reactivity
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Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages
-
Year
2024
-
Journal
MOLECULES
-
Authors
Shian Hu, et al.
-
Applications
Unspecified
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Reactivity
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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
-
Year
2023
-
Journal
Cell Metabolism
-
Authors
Hyunsoo Rho, et al.
-
Applications
Unspecified
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Reactivity
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The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity
-
Year
2023
-
Journal
Cell Metabolism
-
Authors
Xuedan Sun, et al.
-
Applications
Unspecified
-
Reactivity
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ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation
-
Year
2023
-
Journal
Science Advances
-
Authors
Mengshu Jia, et al.
-
Applications
Unspecified
-
Reactivity
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High-Intensity Interval Training Induces Protein Lactylation in Different Tissues of Mice with Specificity and Time Dependence
-
Year
2023
-
Journal
Metabolites
-
Authors
Wenhua Huang, et al.
-
Applications
Unspecified
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Reactivity
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Lactate dehydrogenase A mediated histone lactylation induced the pyroptosis through targeting HMGB1
-
Year
2023
-
Journal
METABOLIC BRAIN DISEASE
-
Authors
Yao Xuan, et al.
-
Applications
Unspecified
-
Reactivity
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BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development
-
Year
2023
-
Journal
DEVELOPMENTAL CELL
-
Authors
Yanyan Wang, et al.
-
Applications
Unspecified
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Reactivity
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Progesterone activates histone lactylation-Hif1α-glycolysis feedback loop to promote decidualization
-
Year
2023
-
Journal
ENDOCRINOLOGY
-
Authors
Zhao Wei, et al.
-
Applications
Unspecified
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Reactivity
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Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis
-
Year
2023
-
Journal
Clinical Epigenetics
-
Authors
Yin Xiangjun, et al.
-
Applications
Unspecified
-
Reactivity
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Dynamic patterns of histone lactylation during early tooth development in mice
-
Year
2023
-
Journal
JOURNAL OF MOLECULAR HISTOLOGY
-
Authors
Liu Ming, et al.
-
Applications
Unspecified
-
Reactivity
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Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation
-
Year
2023
-
Journal
Frontiers in Physiology
-
Authors
Madison L. Mattingly, et al.
-
Applications
Unspecified
-
Reactivity
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High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis
-
Year
2023
-
Journal
BMC BIOLOGY
-
Authors
Chen Xuefei, et al.
-
Applications
Unspecified
-
Reactivity
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H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
-
Year
2023
-
Journal
Journal of Neuroinflammation
-
Authors
Wei Lin, et al.
-
Applications
Unspecified
-
Reactivity
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α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
-
Year
2023
-
Journal
CELL RESEARCH
-
Authors
Zhang Naijin, et al.
-
Applications
Unspecified
-
Reactivity
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Lactate induces tumor-associated macrophage polarization independent of mitochondrial pyruvate carrier-mediated metabolism
-
Year
2023
-
Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
-
Authors
Xia Fang, et al.
-
Applications
Unspecified
-
Reactivity
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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation.
-
Year
2023
-
Journal
Cell Reports
-
Authors
He Y, et al.
-
Applications
Unspecified
-
Reactivity
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Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease
-
Year
2022
-
Journal
Cell Metabolism
-
Authors
Rui-Yuan Pan, et al.
-
Applications
Unspecified
-
Reactivity
-
ULK1-Mediated Metabolic Reprogramming Regulates Vps34 Lipid Kinase Activity by Its Lactylation
-
Year
2022
-
Journal
MOLECULAR CELL
-
Authors
Yue Xiao, et al.
-
Applications
Unspecified
-
Reactivity
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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
-
Year
2022
-
Journal
MOLECULAR CELL
-
Authors
Jia Xiong, et al.
-
Applications
Unspecified
-
Reactivity
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H3K18 lactylation marks tissue-specific active enhancers
-
Year
2022
-
Journal
GENOME BIOLOGY
-
Authors
Galle Eva, et al.
-
Applications
Unspecified
-
Reactivity
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Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease
-
Year
2022
-
Journal
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
-
Authors
Dang Lin, et al.
-
Applications
Unspecified
-
Reactivity
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Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
-
Year
2022
-
Journal
Science Advances
-
Authors
Carlos Moreno-Yruela, et al.
-
Applications
Unspecified
-
Reactivity
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The global succinylation of SARS-CoV-2–infected host cells reveals drug targets
-
Year
2022
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
-
Authors
Quan Liu, et al.
-
Applications
Unspecified
-
Reactivity
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YY1 Lactylation in Microglia Promotes Angiogenesis Through Transcription Activation-Mediated Upregulation of FGF2
-
Year
2022
-
Journal
Cell Reports
-
Authors
Wang Xiaotang, et al.
-
Applications
Unspecified
-
Reactivity
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Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production
-
Year
2022
-
Journal
BRITISH JOURNAL OF CANCER
-
Authors
Blaszczak Wiktoria, et al.
-
Applications
Unspecified
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Reactivity
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Transgenic construction and functional miRNA analysis identify the role of miR-7 in prostate cancer suppression
-
Year
2022
-
Journal
ONCOGENE
-
Authors
Wang Can, et al.
-
Applications
Unspecified
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Reactivity
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Effect of lactylation on functional and structural properties of gluten
-
Year
2022
-
Journal
Frontiers in Nutrition
-
Authors
Yu Wang, et al.
-
Applications
Unspecified
-
Reactivity
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Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii
-
Year
2022
-
Journal
GENOMICS PROTEOMICS & BIOINFORMATICS
-
Authors
Deqi Yin, et al.
-
Applications
Unspecified
-
Reactivity
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Single-Embryo Transcriptomic Atlas of Oxygen Response Reveals the Critical Role of HIF-1α in Prompting Major Zygotic Gene Activation
-
Year
2022
-
Journal
iScience
-
Authors
Yao Fusheng, et al.
-
Applications
Unspecified
-
Reactivity
-
Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia
-
Year
2022
-
Journal
JOURNAL OF HYPERTENSION
-
Authors
Li Xiang, et al.
-
Applications
Unspecified
-
Reactivity
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LDHA promotes osteoblast differentiation through histone lactylation
-
Year
2022
-
Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
-
Authors
Feige Nian, et al.
-
Applications
Unspecified
-
Reactivity
-
Effect of lactylation on functional and structural properties of gluten.
-
Year
2022
-
Journal
Frontiers in Nutrition
-
Authors
Yu Wang, et al.
-
Applications
Unspecified
-
Reactivity
-
Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE
-
Year
2021
-
Journal
CELL
-
Authors
Simone Caielli, et al.
-
Applications
Unspecified
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Reactivity
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Lactate and IL6 define separable paths of inflammatory metabolic adaptation
-
Year
2021
-
Journal
Science Advances
-
Authors
Stefanie Dichtl, et al.
-
Applications
Unspecified
-
Reactivity
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Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma
-
Year
2021
-
Journal
GENOME BIOLOGY
-
Authors
Yu Jie, et al.
-
Applications
Unspecified
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Reactivity
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Protein lactylation induced by neural excitation
-
Year
2021
-
Journal
Cell Reports
-
Authors
Hideo Hagihara, et al.
-
Applications
Unspecified
-
Reactivity
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Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota.
-
Year
2021
-
Journal
Frontiers in Immunology
-
Authors
Sun S, et al.
-
Applications
Unspecified
-
Reactivity
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Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation
-
Year
2021
-
Journal
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
-
Authors
Huachun Cui, et al.
-
Applications
Unspecified
-
Reactivity
-
Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer
-
Year
2021
-
Journal
Frontiers in Oncology
-
Authors
Jiang Jun, et al.
-
Applications
Unspecified
-
Reactivity
-
Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains
-
Year
2021
-
Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
-
Authors
Xiaoxi Meng, et al.
-
Applications
Unspecified
-
Reactivity
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Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice
-
Year
2021
-
Journal
Epigenetics & Chromatin
-
Authors
Yang Wanting, et al.
-
Applications
Unspecified
-
Reactivity
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Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota
-
Year
2021
-
Journal
Frontiers in Immunology
-
Authors
Sun Siyuan, et al.
-
Applications
Unspecified
-
Reactivity
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Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
-
Year
2020
-
Journal
Nature Metabolism
-
Authors
Li Linpeng, et al.
-
Applications
Unspecified
-
Reactivity
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TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation
-
Year
2020
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
-
Authors
Ricardo A. Irizarry-Caro, et al.
-
Applications
Unspecified
-
Reactivity
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Dynamic Profiles and Transcriptional Preferences of Histone Modifications During Spermiogenesis
-
Year
2020
-
Journal
ENDOCRINOLOGY
-
Authors
Li Yinchuan, et al.
-
Applications
Unspecified
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Reactivity
-
Metabolic regulation of gene expression by histone lactylation
-
Year
2019
-
Journal
NATURE
-
Authors
Zhang Di, et al.
-
Applications
Unspecified
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Reactivity
