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Anti-Malonyllysine Mouse mAb
Catalog Number: PTM-902
$ 390

Clone Number: /

Host: Mouse Clonality: Monoclonal

Applications： WB

Reactivity: All

Synonyms: Kmal

Product Size
100 μl
Quantity

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms Kmal
UniProt ID

/

Immunogen Malonylated lysine peptides
MW (kDa) Multiple
Specificity Anti-Malonyllysine Mouse mAb detects proteins with malonylated lysine residues. This pan antibody recognizes malonylated lysine independent of its surrounding sequences.
Product Usage Information
Applications Dilution Recommended Species
WB 1:500 - 1:1000 All
Properties
Purity Protein G and immunogen affinity purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

Malonylation of lysine is a newly identified reversible modification controlling protein activity. Sirt5, a regulatory enzyme for lysine malonylation, can catalyze lysine demalonylation reactions in vivo and in vitro. Through integrated proteomic approaches and biochemistry analysis, it has been found that lysine malonylation is widely distributed acrossvarious histones and non-histone substrates. Lysine malonylation may provide a new paradigm in cellular regulation, such as energy metabolism in diverse organisms.

Cellular location

/

Images
Dot Blot

Peptide amount: Dot A1, 4 ng; Dot B1, 20 ng; Dot C1, 100 ng; Lane 2-4, 100 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Mouse IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
The list of peptides used in the experiment is provided below.
Lane 1: Malonyllysine peptide library.
Lane 2: Histone site specific malonyllysine peptides of various sequence contexts.
Dot A3: Histone site specific malonyllysine peptide
Dot B3: Histone site specific malonyllysine peptide
Dot C3: Glutaryllysine peptide library.
Dot A4: Succinyllysine peptide library.
Dot B4: Propionyllysine peptide library.
Dot C4: Unmodified peptide library.
WB

Lysates: JK and 293T cells
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Mouse IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: Multiple
Observed band size: Multiple

Research Use

For research use only, not for use in diagnostic procedures.

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References (25)
  • Electroacupuncture regulates histone acetylation to improve spatial memory impairment in rats with chronic cerebral hypoperfusion
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    Journal Journal of Integrative Medicine-JIM
    Authors Yan-yi Ding, et al.
    Applications Unspecified
    Reactivity
  • HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma
    Year 2025
    Journal Cell Death & Disease
    Authors He Jiang, et al.
    Applications Unspecified
    Reactivity
  • Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis
    Year 2025
    Journal Exploration
    Authors Tongtong Liu, et al.
    Applications Unspecified
    Reactivity
  • Identification of the malonylation modification in Staphylococcus aureus and insight into the regulators in biofilm formation
    Year 2025
    Journal Frontiers in Microbiology
    Authors Xiaoyan Yu, et al.
    Applications Unspecified
    Reactivity
  • Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
    Year 2025
    Journal Signal Transduction and Targeted Therapy
    Authors She Han, et al.
    Applications Unspecified
    Reactivity
  • SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation
    Year 2025
    Journal PLoS Pathogens
    Authors Zhuang Li, et al.
    Applications Unspecified
    Reactivity
  • Quantitative Proteomic Analysis of Lysine Malonylation in Response to Salicylic Acid in the Roots of Platycodon grandiflorus
    Year 2025
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Wanyue Ding, et al.
    Applications Unspecified
    Reactivity
  • Systematic qualitative proteome-wide analysis of lysine malonylation profiling in Platycodon grandiflorus
    Year 2025
    Journal AMINO ACIDS
    Authors Yang Qingshan, et al.
    Applications Unspecified
    Reactivity
  • Increased DNMT1 acetylation leads to global DNA methylation suppression in follicular granulosa cells during reproductive aging in mammals
    Year 2024
    Journal BMC GENOMICS
    Authors Zhao Shunran, et al.
    Applications Unspecified
    Reactivity
  • Lactylation of RNA m6A demethylase ALKBH5 promotes innate immune response to DNA herpesviruses and mpox virus
    Year 2024
    Journal PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    Authors Wan Li, et al.
    Applications Unspecified
    Reactivity
  • Targeting the transmembrane cytokine co-receptor neuropilin-1 in distal tubules improves renal injury and fibrosis
    Year 2024
    Journal Nature Communications
    Authors Li Yinzheng, et al.
    Applications Unspecified
    Reactivity
  • Comprehensive Proteome and Acetylome Analysis of Needle Senescence in Larix gmelinii
    Year 2024
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Xuting Zhang, et al.
    Applications Unspecified
    Reactivity
  • SIRT5 alleviates liver ischemia/reperfusion injury by regulating mitochondrial succinylation and oxidative stress
    Year 2023
    Journal ANTIOXIDANTS & REDOX SIGNALING
    Authors Prof. Jihong Yao, et al.
    Applications Unspecified
    Reactivity
  • The Enzyme Lysine Malonylation of Calvin Cycle and Gluconeogenesis Regulated Glycometabolism in Nostoc flagelliforme to Adapt to Drought Stress
    Year 2023
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Meng Wang, et al.
    Applications Unspecified
    Reactivity
  • Global proteomic analysis reveals lysine succinylation contributes to the pathogenesis of aortic aneurysm and dissection
    Year 2023
    Journal Journal of Proteomics
    Authors Hongwei Zhang, et al.
    Applications Unspecified
    Reactivity
  • Tandem mass tag-based quantitative proteomic analysis identification of succinylation related proteins in pathogenesis of thoracic aortic aneurysm and aortic dissection
    Year 2023
    Journal PeerJ
    Authors Yu Zhang, et al.
    Applications Unspecified
    Reactivity
  • TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
    Year 2022
    Journal EMBO JOURNAL
    Authors Qichao Huang, et al.
    Applications Unspecified
    Reactivity
  • GABA regulates IL-1β production in macrophages
    Year 2022
    Journal Cell Reports
    Authors Jian Fu, et al.
    Applications Unspecified
    Reactivity
  • Systematic analysis of lysine malonylation in Streptococcus mutans
    Year 2022
    Journal Frontiers in Cellular and Infection Microbiology
    Authors Li Zhengyi, et al.
    Applications Unspecified
    Reactivity
  • Cold Atmospheric Plasma Conveys Selectivity Against Hepatocellular Carcinoma Cells via Triggering EGFR(Tyr1068)-Mediated Autophagy
    Year 2022
    Journal Frontiers in Oncology
    Authors Danjun Wang, et al.
    Applications Unspecified
    Reactivity
  • Integrated insights into the mechanisms underlying sepsis-induced myocardial depression using a quantitative global proteomic analysis
    Year 2022
    Journal Journal of Proteomics
    Authors Ni Yang, et al.
    Applications Unspecified
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  • The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum
    Year 2021
    Journal eLife
    Authors Ning Zhang, et al.
    Applications Unspecified
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  • Global Identification and Systematic Analysis of Lysine Malonylation in Maize (Zea mays L.)
    Year 2021
    Journal Frontiers in Plant Science
    Authors Xu Min, et al.
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  • Antimicrobial Peptide BCp12 Inhibits Staphylococcus aureus Growth by Altering Lysine Malonylation Levels in the Arginine Synthesis Pathway
    Year 2021
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    Authors Yanan Shi, et al.
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