Background
The post-translational ε-amino lysine methylation of proteins is an important reversible modification controlling protein activity. The reversible lysine methylation of proteins plays a vital role in the regulation of many cellular processes including chromatin remodeling, gene expression, cell proliferation, etc. Methylation of lysine residues is modulated by specific counteractive enzymes including lysine methylases (KMTs), demethylases (KDMs), histone methylases (HMTs), and histone demethylases (HDMs), whose pathways have become promising targets for discovery of anti-cancer drugs.
Cellular location
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