Background
Protein phosphorylation is a common post-translational modification that can occur on many types of amino acids, such as tyrosine, serine, and threonine. The phosphorylation of threonine residues is related to many growth factors and oncogene protein kinases and plays an important role in the signal transduction of protein activation, cell proliferation and differentiation. The study of the transformation mechanism of oncogenes and growth factors in the mitogenic process depends on the identification of their substrates and subsequent determination of how phosphorylation affects their properties. The antibody that specifically recognizes amino acid phosphorylation can quickly identify, quantify, and immunoaffinityly separate cellular phosphorylated proteins, and can be used as an analysis and preparation tool, which is of inestimable value to the above-mentioned research.
Cellular location
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