Background
Ribosomal protein S3 (RPS3) is a component of the 40S ribosomal subunit and is involved in translation. HSP90 interacts with both the amino-terminus and carboxy-terminus of RPS3, preventing its ubiquitination and degradation and thereby retaining the integrity of the ribosome. RPS3 has also been shown to function as an endonuclease during DNA damage repair. Furthermore, overexpression of RPS3 sensitizes lymphocytic cells to cytokine-induced apoptosis, indicating a third role for RPS3 during apoptosis.
Cellular location
Cytoplasm