-
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
-
Year
2026
-
Journal
MOLECULAR CELL
-
Authors
Zhe Wang, et al.
-
Applications
Unspecified
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Reactivity
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Lysine malonylation regulates human sperm motility
-
Year
2026
-
Journal
Communications Biology
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Authors
Cheng Yimin, et al.
-
Applications
Unspecified
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Reactivity
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A Combined SIRT5 Activation and SIRT3 Inhibition Prevents Breast Cancer Spheroids Growth by Reducing HIF-1α and Mitophagy
-
Year
2025
-
Journal
Pharmaceuticals
-
Authors
Federica Barreca, et al.
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Applications
Unspecified
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Reactivity
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Electroacupuncture regulates histone acetylation to improve spatial memory impairment in rats with chronic cerebral hypoperfusion
-
Year
2025
-
Journal
Journal of Integrative Medicine-JIM
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Authors
Yan-yi Ding, et al.
-
Applications
Unspecified
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Reactivity
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Succinylation heterogeneity in lung adenocarcinoma: from prognostic model to KLK6-driven tumor microenvironment remodeling
-
Year
2025
-
Journal
Frontiers in Immunology
-
Authors
Jichang Liu, et al.
-
Applications
Unspecified
-
Reactivity
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HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma
-
Year
2025
-
Journal
Cell Death & Disease
-
Authors
He Jiang, et al.
-
Applications
Unspecified
-
Reactivity
-
Salt-sensitive hypertension promotes neuronal mitochondrial stress and neurodegenerative alterations via neuro-vascular metabolic reprogramming and local RAS signaling
-
Year
2025
-
Journal
Journal of Neuroinflammation
-
Authors
Wu Hanxue, et al.
-
Applications
Unspecified
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Reactivity
-
Bushen Tiaojing Decoction promotes endometrial angiogenesis to improve endometrial receptivity by regulating KLF4-mediated mitochondrial function and transcription activity
-
Year
2025
-
Journal
JOURNAL OF ETHNOPHARMACOLOGY
-
Authors
Can Cao, et al.
-
Applications
Unspecified
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Reactivity
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Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis
-
Year
2025
-
Journal
Exploration
-
Authors
Tongtong Liu, et al.
-
Applications
Unspecified
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Reactivity
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High-throughput screening identifies a dual-activity inhibitor of OXCT1 for hepatocellular carcinoma therapy
-
Year
2025
-
Journal
BIOORGANIC CHEMISTRY
-
Authors
Rui Liu, et al.
-
Applications
Unspecified
-
Reactivity
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YTHDC1 lactylation regulates its phase separation to enhance target mRNA stability and promote RCC progression
-
Year
2025
-
Journal
MOLECULAR CELL
-
Authors
Chenyun Dai, et al.
-
Applications
Unspecified
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Reactivity
-
Sirtuin 5 inhibits mitochondrial metabolism in liver cancer cells and promotes apoptosis by mediating the desuccinylation of CS
-
Year
2025
-
Journal
Frontiers in Immunology
-
Authors
Huimin Cao, et al.
-
Applications
Unspecified
-
Reactivity
-
Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
-
Year
2025
-
Journal
Signal Transduction and Targeted Therapy
-
Authors
She Han, et al.
-
Applications
Unspecified
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Reactivity
-
Proteomics and succinylation modification characterization in clear cell renal cell carcinoma
-
Year
2025
-
Journal
Discover Oncology
-
Authors
Yue Dong, et al.
-
Applications
Unspecified
-
Reactivity
-
Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression
-
Year
2025
-
Journal
CANCER RESEARCH
-
Authors
Wang Kun, et al.
-
Applications
Unspecified
-
Reactivity
-
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation
-
Year
2025
-
Journal
PLoS Pathogens
-
Authors
Zhuang Li, et al.
-
Applications
Unspecified
-
Reactivity
-
GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis
-
Year
2025
-
Journal
CELL DEATH AND DIFFERENTIATION
-
Authors
Chen Zixiang, et al.
-
Applications
Unspecified
-
Reactivity
-
Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation
-
Year
2025
-
Journal
Nature Communications
-
Authors
Zhang Ning, et al.
-
Applications
Unspecified
-
Reactivity
-
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity
-
Year
2025
-
Journal
FEBS Journal
-
Authors
Dayoung Yu, et al.
-
Applications
Unspecified
-
Reactivity
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Sirt5-mediated polarization and metabolic reprogramming of macrophage sustain brain function following ischemic stroke
-
Year
2025
-
Journal
BRAIN RESEARCH
-
Authors
Linfeng Zhang, et al.
-
Applications
Unspecified
-
Reactivity
-
Gut flora-derived succinate exacerbates Allergic Airway Inflammation by promoting protein succinylation
-
Year
2025
-
Journal
Redox Biology
-
Authors
Chao Wang, et al.
-
Applications
Unspecified
-
Reactivity
-
CPT1A ameliorates microglia-induced neuroinflammation via facilitating VDR succinylation
-
Year
2025
-
Journal
Scientific Reports
-
Authors
Li Wenyao, et al.
-
Applications
Unspecified
-
Reactivity
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The Moonlighting Function of Glutamin Synthase 2 Promotes Immune Evasion of Pancreatic Ductal Adenocarcinoma by Tubulin Tyrosine Ligase-like 1-Mediated Yes1 Associated Transcriptional Regulator Glutamylation
-
Year
2025
-
Journal
GASTROENTEROLOGY
-
Authors
Xiao Chen, et al.
-
Applications
Unspecified
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Reactivity
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Moxibustion Alleviates Inflammation via SIRT5-mediated Post-translational Modification and Macrophage Polarization
-
Year
2025
-
Journal
INFLAMMATION
-
Authors
Zuo Chuan-yi, et al.
-
Applications
Unspecified
-
Reactivity
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Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation
-
Year
2025
-
Journal
Nature Microbiology
-
Authors
Li Linxing, et al.
-
Applications
Unspecified
-
Reactivity
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Comprehensive analysis of the succinylome in Vero cells infected with peste des petits ruminants virus Nigeria 75/1 vaccine strain
-
Year
2025
-
Journal
BMC Veterinary Research
-
Authors
Meng Xuelian, et al.
-
Applications
Unspecified
-
Reactivity
-
OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth
-
Year
2025
-
Journal
MOLECULAR CELL
-
Authors
Dong Guo, et al.
-
Applications
Unspecified
-
Reactivity
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Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis
-
Year
2024
-
Journal
Cell Reports
-
Authors
Xuedi Zhang, et al.
-
Applications
Unspecified
-
Reactivity
-
Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
-
Year
2024
-
Journal
Cell Metabolism
-
Authors
Ruilong Liu, et al.
-
Applications
Unspecified
-
Reactivity
-
Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome
-
Year
2024
-
Journal
Biomolecules
-
Authors
Yuxun Zhang, et al.
-
Applications
Unspecified
-
Reactivity
-
Succinylation modification-mediated upregulation of Sp1 promotes hepatocellular carcinoma cell proliferation
-
Year
2024
-
Journal
Discover Oncology
-
Authors
Han Yehong, et al.
-
Applications
Unspecified
-
Reactivity
-
Increased DNMT1 acetylation leads to global DNA methylation suppression in follicular granulosa cells during reproductive aging in mammals
-
Year
2024
-
Journal
BMC GENOMICS
-
Authors
Zhao Shunran, et al.
-
Applications
Unspecified
-
Reactivity
-
Drug repurposing: An antidiabetic drug Ipragliflozin as Mycobacterium tuberculosis sirtuin-like protein inhibitor that synergizes with anti-tuberculosis drug isoniazid
-
Year
2024
-
Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
-
Authors
Junfeng Zhen, et al.
-
Applications
Unspecified
-
Reactivity
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Lactylation of RNA m6A demethylase ALKBH5 promotes innate immune response to DNA herpesviruses and mpox virus
-
Year
2024
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
-
Authors
Wan Li, et al.
-
Applications
Unspecified
-
Reactivity
-
Astragaloside IV protects renal tubular epithelial cells against oxidative stress-induced injury by upregulating CPT1A-mediated HSD17B10 lysine succinylation in diabetic kidney disease
-
Year
2024
-
Journal
PHYTOTHERAPY RESEARCH
-
Authors
Meng Wang, et al.
-
Applications
Unspecified
-
Reactivity
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Targeting the transmembrane cytokine co-receptor neuropilin-1 in distal tubules improves renal injury and fibrosis
-
Year
2024
-
Journal
Nature Communications
-
Authors
Li Yinzheng, et al.
-
Applications
Unspecified
-
Reactivity
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Thiol-Mediated Enhancement of Nε-Acetyllysine Formation in Lens Proteins
-
Year
2024
-
Journal
ACS Chemical Biology
-
Authors
Sudipta Panja, et al.
-
Applications
Unspecified
-
Reactivity
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Comprehensive Proteome and Acetylome Analysis of Needle Senescence in Larix gmelinii
-
Year
2024
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
-
Authors
Xuting Zhang, et al.
-
Applications
Unspecified
-
Reactivity
-
Lysine 2-hydroxyisobutyrylation proteomics analyses reveal the regulatory mechanism of CaMYB61-CaAFR1 module in regulating stem development in Capsicum annuum L.
-
Year
2024
-
Journal
PLANT JOURNAL
-
Authors
Qing Li, et al.
-
Applications
Unspecified
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Reactivity
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Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
-
Year
2024
-
Journal
iScience
-
Authors
Taolin Yuan, et al.
-
Applications
Unspecified
-
Reactivity
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The crotonylated and succinylated proteins of jujube involved in phytoplasma-stress responses
-
Year
2024
-
Journal
BMC BIOLOGY
-
Authors
Liman Zhang, et al.
-
Applications
Unspecified
-
Reactivity
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SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1
-
Year
2024
-
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
-
Authors
Jin Xinxin, et al.
-
Applications
Unspecified
-
Reactivity
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Succinylation of Park 7 Activates a Protective Metabolic Response to Acute Kidney Injury
-
Year
2024
-
Journal
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
-
Authors
Katherine Pfister, et al.
-
Applications
Unspecified
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Reactivity
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Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
-
Year
2024
-
Journal
Nature Chemistry
-
Authors
Weyh Maria, et al.
-
Applications
Unspecified
-
Reactivity
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TIGAR reduces neuronal ferroptosis by inhibiting succinate dehydrogenase activity in cerebral ischemia
-
Year
2024
-
Journal
FREE RADICAL BIOLOGY AND MEDICINE
-
Authors
Xinxin Wang, et al.
-
Applications
Unspecified
-
Reactivity
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Global proteomic analysis reveals lysine succinylation is involved in the pathogenesis of hypertrophic scar
-
Year
2024
-
Journal
Journal of Proteomics
-
Authors
Keqing Qiu, et al.
-
Applications
Unspecified
-
Reactivity
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SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23
-
Year
2024
-
Journal
BMC CANCER
-
Authors
Wu Yongkang, et al.
-
Applications
Unspecified
-
Reactivity
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Sub-MIC vancomycin enhances the antibiotic tolerance of vancomycin-intermediate Staphylococcus aureus through downregulation of protein succinylation
-
Year
2024
-
Journal
MICROBIOLOGICAL RESEARCH
-
Authors
Yi Yang, et al.
-
Applications
Unspecified
-
Reactivity
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Succinylated acetyl-CoA carboxylase contributes to aflatoxin biosynthesis, morphology development, and pathogenicity in Aspergillus flavus
-
Year
2024
-
Journal
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
-
Authors
Rui Xie, et al.
-
Applications
Unspecified
-
Reactivity
-
Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer
-
Year
2024
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
-
Authors
Qingzhi Ma, et al.
-
Applications
Unspecified
-
Reactivity
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HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation
-
Year
2023
-
Journal
Cell Discovery
-
Authors
Li Jialun, et al.
-
Applications
Unspecified
-
Reactivity
-
Core-predominant gut fungus Kazachstania slooffiae promotes intestinal epithelial glycolysis via lysine desuccinylation in pigs
-
Year
2023
-
Journal
Microbiome
-
Authors
Hu Jun, et al.
-
Applications
Unspecified
-
Reactivity
-
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis
-
Year
2023
-
Journal
EXPERIMENTAL AND MOLECULAR MEDICINE
-
Authors
Mao Jianxin, et al.
-
Applications
Unspecified
-
Reactivity
-
SIRT5 alleviates liver ischemia/reperfusion injury by regulating mitochondrial succinylation and oxidative stress
-
Year
2023
-
Journal
ANTIOXIDANTS & REDOX SIGNALING
-
Authors
Prof. Jihong Yao, et al.
-
Applications
Unspecified
-
Reactivity
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STUB1-mediated ubiquitination regulates the stability of GLUD1 in lung adenocarcinoma
-
Year
2023
-
Journal
iScience
-
Authors
Qifan Hu, et al.
-
Applications
Unspecified
-
Reactivity
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Proteomics and β-hydroxybutyrylation Modification Characterization in the Hearts of Naturally Senescent Mice
-
Year
2023
-
Journal
MOLECULAR & CELLULAR PROTEOMICS
-
Authors
Xuechun Yang, et al.
-
Applications
Unspecified
-
Reactivity
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Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells
-
Year
2023
-
Journal
Life Science Alliance
-
Authors
Yifan Jiang, et al.
-
Applications
Unspecified
-
Reactivity
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Structure–Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury
-
Year
2023
-
Journal
JOURNAL OF MEDICINAL CHEMISTRY
-
Authors
Luohe Mou, et al.
-
Applications
Unspecified
-
Reactivity
-
SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis
-
Year
2023
-
Journal
CELL DEATH AND DIFFERENTIATION
-
Authors
Li Yutong, et al.
-
Applications
Unspecified
-
Reactivity
-
Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure
-
Year
2022
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
-
Authors
Shingo Takada, et al.
-
Applications
Unspecified
-
Reactivity
-
GABA regulates IL-1β production in macrophages
-
Year
2022
-
Journal
Cell Reports
-
Authors
Jian Fu, et al.
-
Applications
Unspecified
-
Reactivity
-
Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis
-
Year
2022
-
Journal
Cell Reports
-
Authors
Zilong Zheng, et al.
-
Applications
Unspecified
-
Reactivity
-
The freezability of Mediterranean buffalo sperm is associated with lysine succinylation and lipid metabolism
-
Year
2022
-
Journal
FASEB JOURNAL
-
Authors
Xi Luo, et al.
-
Applications
Unspecified
-
Reactivity
-
GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis
-
Year
2022
-
Journal
iScience
-
Authors
Can Cao, et al.
-
Applications
Unspecified
-
Reactivity
-
Integrated insights into the mechanisms underlying sepsis-induced myocardial depression using a quantitative global proteomic analysis
-
Year
2022
-
Journal
Journal of Proteomics
-
Authors
Ni Yang, et al.
-
Applications
Unspecified
-
Reactivity
-
First analyses of lysine succinylation proteome and overlap between succinylation and acetylation in Solenopsis invicta Buren (Hymenoptera: Formicidae)
-
Year
2022
-
Journal
BMC GENOMICS
-
Authors
Ye Jingwen, et al.
-
Applications
Unspecified
-
Reactivity
-
The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum
-
Year
2021
-
Journal
eLife
-
Authors
Ning Zhang, et al.
-
Applications
Unspecified
-
Reactivity
-
Cardioprotective Role of SIRT5 in Response to Acute Ischemia Through a Novel Liver-Cardiac Crosstalk Mechanism
-
Year
2021
-
Journal
Frontiers in Cell and Developmental Biology
-
Authors
Zhou Boda, et al.
-
Applications
Unspecified
-
Reactivity
-
Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA
-
Year
2021
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
-
Authors
Luisa Siculella, et al.
-
Applications
Unspecified
-
Reactivity
-
First Succinylome Profiling of Vibrio alginolyticus Reveals Key Role of Lysine Succinylation in Cellular Metabolism and Virulence
-
Year
2021
-
Journal
Frontiers in Cellular and Infection Microbiology
-
Authors
Zeng Fuyuan, et al.
-
Applications
Unspecified
-
Reactivity
-
Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies
-
Year
2021
-
Journal
Scientific Reports
-
Authors
Kollenstart Leonie, et al.
-
Applications
Unspecified
-
Reactivity
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Global analysis of protein succinylation modification of Nostoc flagelliforme in response to dehydration
-
Year
2021
-
Journal
Journal of Proteomics
-
Authors
Xiaoxu Li, et al.
-
Applications
Unspecified
-
Reactivity
-
Malonyl-proteome profiles of Staphylococcus aureus reveal lysine malonylation modification in enzymes involved in energy metabolism
-
Year
2021
-
Journal
Proteome Science
-
Authors
Shi Yanan, et al.
-
Applications
Unspecified
-
Reactivity
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SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose-derived mesenchymal stem cells via metabolic switching
-
Year
2020
-
Journal
Clinical and Translational Medicine
-
Authors
Tiantong Ou, et al.
-
Applications
Unspecified
-
Reactivity
-
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis
-
Year
2019
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
-
Authors
Kai Su Greene, et al.
-
Applications
Unspecified
-
Reactivity
-
Lysine glutarylation in human sperm is associated with progressive motility
-
Year
2019
-
Journal
HUMAN REPRODUCTION
-
Authors
Cheng Yi-min, et al.
-
Applications
Unspecified
-
Reactivity
-
Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy
-
Year
2019
-
Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
-
Authors
Hadi R. Ali, et al.
-
Applications
Unspecified
-
Reactivity
-
Protein kinase Cα mediates recovery of renal and mitochondrial functions following acute injury
-
Year
2019
-
Journal
FEBS Journal
-
Authors
Grazyna Nowak, et al.
-
Applications
Unspecified
-
Reactivity
-
OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer
-
Year
2019
-
Journal
EXPERIMENTAL CELL RESEARCH
-
Authors
Xin Lu, et al.
-
Applications
Unspecified
-
Reactivity
-
Dose-response regulation system for improving renal injury in diabetic nephropathy by buckwheat hull flavonoids
-
Year
2019
-
Journal
Journal of Functional Foods
-
Authors
Yufang Tang, et al.
-
Applications
Unspecified
-
Reactivity
-
Succinylation Is a Gain-of-Function Modification in Human Lens αB-Crystallin
-
Year
2019
-
Journal
BIOCHEMISTRY
-
Authors
Sandip K. Nandi, et al.
-
Applications
Unspecified
-
Reactivity
-
SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress
-
Year
2019
-
Journal
PLoS One
-
Authors
Mengli Zhang, et al.
-
Applications
Unspecified
-
Reactivity
-
Elevated lysine crotonylation and succinylation in the brains of BTBR mice
-
Year
2019
-
Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
-
Authors
Min Wang, et al.
-
Applications
Unspecified
-
Reactivity
-
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell ProliferationDesuccinylation of SHMT2 by SIRT5 Promotes Tumor Cell Growth
-
Year
2018
-
Journal
CANCER RESEARCH
-
Authors
Yang Xin, et al.
-
Applications
Unspecified
-
Reactivity
-
Characterization of the Sperm Proteome and Reproductive Outcomes with in Vitro, Fertilization after a Reduction in Male Ejaculatory Abstinence Period *
-
Year
2018
-
Journal
MOLECULAR & CELLULAR PROTEOMICS
-
Authors
Zi-Qi Shen, et al.
-
Applications
Unspecified
-
Reactivity
-
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
-
Year
2018
-
Journal
CANCER RESEARCH
-
Authors
Yang Xin, et al.
-
Applications
Unspecified
-
Reactivity
-
SIRT5 regulation of ammonia-induced autophagy and mitophagy
-
Year
2015
-
Journal
Autophagy
-
Authors
Lucia Polletta, et al.
-
Applications
Unspecified
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Reactivity
