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After the differentially expressed protein-based enrichment analysis of GO, KEGG pathway and protein domain in different comparison groups, we performed cluster analysis to find the correlation of functions between differentially expressed proteins from different comparison groups.
According to the Fisher’s exact test P value obtained by the enrichment analysis, the related functions in different comparison groups were gathered with the hierarchical clustering method and draw a heatmap. The horizontal axis of the heatmap is the different comparison groups, and the vertical axis is the description of the related functions (GO, KEGG pathway, Protein domain) enriched by the differentially expressed proteins in the different comparison groups. The color blocks corresponding to the functional description of the enrichment of differentially expressed proteins in different comparison groups indicate the significance of enrichment. Red represents strong enrichment and blue represents weak enrichment.
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