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Protein Kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families. By adding phosphate groups to substrate proteins, they direct the activity, localization and overall function of many proteins, and serve to orchestrate the activity of almost all cellular processes. Kinases are particularly prominent in signal transduction and co-ordination of complex functions such as the cell cycle. Here, we predicted the regulatory relationship between protein kinases and phosphorylation substrates, estimated the kinase activity from the phosphoproteomics datasets, and found the drugs targeted on kinases.
The figure shows the estimation of kinase activity. Red are considered as activated kinases, blue are considered as inhibited kinases.
An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles-2021-Autophagy
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