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Ubiquitination is essential for protein degradation, transcriptional regulation and cell signal transduction in eukaryotic cells. The degree of protein ubiquitination is regulated by E1-E2-E3 cascade and deubiquitination by DUB. UbiBrowser 2.0 is a comprehensive database for collecting and predicting the interaction between ubiquitin ligase ( E3 ) and deubiquitinase ( DUB ) and substrates. We can extract the ubiquitin ligase (E3) and deubiquitinase ( DUB ) of specific Ub sites based on the database.
The figure shows the network diagram of BABAM2 ubiquitin ligase ( E3 ) predicted by UbiBrowser 2.0 ( upper left ), and the network diagram of RANBP2 deubiquitinating enzyme ( DUB ) ( lower left ). Text in each circle ( e.g., ' H ', ' F ' and ' SO ' ) represents the E3 ligase family.
PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer-2022-International Journal of Biological Sciences
UbiBrowser 2.0: a comprehensive resource for proteome-wide ubiquitin ligase/deubiquitinase-substrate interactions in eukaryotic species-2022-Nucleic Acids Research
An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network-2017-Nature Communications
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