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Cancer Epigenetic Products

Epigenetic changes cooperate with genetic alterations to play key roles in cancer initiation and progression. These changes involve DNA methylation, histone modification, histone modifying enzymes, and chromatin remodeling that regulate gene expression. PTMab® antibodies spanning important epigenetic markers, regulators, and histone modifications offers critical tools for cancer epigenetics, to enable studies in mechanism underlying cancer phenotypes and provide implications for cancer detection, prevention, and even treatment. Here are our products for key cancer epigenetic targets relevant to:

Cytosine nucleotides on DNA can be modified by methyl and hydroxymethyl groups under the regulation of regulation of DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) enzymes. Aberrant methylation and hydroxymethylation patterns are found in human tumors and associated with developmental abnormalities.
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    Recombinant
    Anti-SND1 Mouse mAb
    $280
    Catalog #
    PTM-5406
    Host
    Mouse
    Clonality
    Recombinant Monoclonal
    Conjugate
    Unconjugated
    Reactivity
    Human
    Applications：
    WB
    IHC-P
    ICC/IF
    FC
    IAP
    IP
    ChIP
    mIHC-P
RNA modifications occur on all four bases of RNA and are the most abundant in transfer RNA (tRNA) and ribosomal RNA (rRNA). Modifications such as N6-methyladenosine (m6A), 5-methylcytosine (m5C) and pseudouridine (Ψ) are closely related to various cancers.
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    Recombinant
    Anti-SND1 Mouse mAb
    $280
    Catalog #
    PTM-5854
    Host
    Mouse
    Clonality
    Recombinant Monoclonal
    Conjugate
    Unconjugated
    Reactivity
    Human,Mouse
    Applications：
    WB
    IHC-P
    ICC/IF
    FC
    IAP
    IP
    ChIP
    mIHC-P
Post-translational modifications of histones are involved in transcription, chromatin structure, and DNA repair. We have developed over 300 histone modification antibodies, featuring the most comprehensive connection to specific marks, including both well-known (lysine acetylation and methylation), and recently identified histone marks (lysine lactylation, succinylation, crotonylation, and β-hydroxybutyryation).