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Cancer Epigenetic Products

Epigenetic changes cooperate with genetic alterations to play key roles in cancer initiation and progression. These changes involve DNA methylation, histone modification, histone modifying enzymes, and chromatin remodeling that regulate gene expression. PTMab® antibodies spanning important epigenetic markers, regulators, and histone modifications offers critical tools for cancer epigenetics, to enable studies in mechanism underlying cancer phenotypes and provide implications for cancer detection, prevention, and even treatment. Here are our products for key cancer epigenetic targets relevant to:

Cytosine nucleotides on DNA can be modified by methyl and hydroxymethyl groups under the regulation of regulation of DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) enzymes. Aberrant methylation and hydroxymethylation patterns are found in human tumors and associated with developmental abnormalities.
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    Recombinant
    Anti-SND1 Mouse mAb
    $280
    Catalog #
    PTM-5406
    Host
    Mouse
    Clonality
    Recombinant Monoclonal
    Conjugate
    Unconjugated
    Reactivity
    Human
    Applications：
    WB
    IHC-P
    ICC/IF
    FC
    IAP
    IP
    ChIP
    mIHC-P
RNA modifications occur on all four bases of RNA and are the most abundant in transfer RNA (tRNA) and ribosomal RNA (rRNA). Modifications such as N6-methyladenosine (m6A), 5-methylcytosine (m5C) and pseudouridine (Ψ) are closely related to various cancers.
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    Recombinant
    Anti-SND1 Mouse mAb
    $280
    Catalog #
    PTM-5854
    Host
    Mouse
    Clonality
    Recombinant Monoclonal
    Conjugate
    Unconjugated
    Reactivity
    Human,Mouse
    Applications：
    WB
    IHC-P
    ICC/IF
    FC
    IAP
    IP
    ChIP
    mIHC-P
Post-translational modifications of histones are involved in transcription, chromatin structure, and DNA repair. We have developed over 300 histone modification antibodies, featuring the most comprehensive connection to specific marks, including both well-known (lysine acetylation and methylation), and recently identified histone marks (lysine lactylation, succinylation, crotonylation, and β-hydroxybutyryation).
Histone modifications consist of three major components: Writers (enzymes that add modifications), Readers (modification-recognizing proteins), and Erasers (enzymes that remove modifications). Mutations and misregulation of histone modifiers are found in various types of cancers and many of these proteins have become targets of drug discovery.
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    Recombinant Rabbit Monoclonal
    Anti-HDAC4 Rabbit mAb
    $280
    Catalog #
    PTM-5551
    Host
    Rabbit
    Clonality
    Recombinant Monoclonal
    Conjugate
    Unconjugated
    Reactivity
    Human,Mouse,Rat
    Applications：
    WB
    IHC-P
    ICC/IF
    FC
    IAP
    IP
    ChIP
    mIHC-P
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    Recombinant
    Anti-HAT1 Mouse mAb
    $280
    Catalog #
    PTM-5195
    Host
    Mouse
    Clonality
    Recombinant Monoclonal
    Conjugate
    Unconjugated
    Reactivity
    Human,Mouse,Rat
    Applications：
    WB
    IHC-P
    ICC/IF
    FC
    IAP
    IP
    ChIP
    mIHC-P
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    Recombinant
    Anti-SIRT1 Mouse mAb
    $280
    Catalog #
    PTM-5021
    Host
    Mouse
    Clonality
    Recombinant Monoclonal
    Conjugate
    Unconjugated
    Reactivity
    Human,Mouse
    Applications：
    WB
    IHC-P
    ICC/IF
    FC
    IAP
    IP
    ChIP
    mIHC-P
Besides Histone modifications, chromatin remodeling complexes containing a series of ATP-dependent remodeling enzymes can also dynamically modify the chromatin architecture by sliding, ejecting, or restructuring nucleosomes. BRG1-associated factor complex (BAF), imitation switch (ISWI), chromodomain-helicase DNA-binding protein (CHD), and inositol-requiring mutant 80 (INO80) are four ATP-dependent chromatin remodeling complex families known in mammals.
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    Recombinant
    Anti-BRG1 Mouse mAb
    $280
    Catalog #
    PTM-5826
    Host
    Mouse
    Clonality
    Recombinant Monoclonal
    Conjugate
    Unconjugated
    Reactivity
    Human,Rat
    Applications：
    WB
    IHC-P
    ICC/IF
    FC
    IAP
    IP
    ChIP
    mIHC-P
Nuclear receptors are a family of transcription factors which can influence epigenetic regulation in cancer and are involved in many forms of cancer.

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